EP 2186913 B1 20160210 - Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
Title (en)
Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
Title (de)
Mit kardiovaskulären Erkrankungen und dem Ansprechen auf Medikation in Zusammenhang stehende Genpolymorphismen, Methoden zu deren Nachweis und deren Verwendung
Title (fr)
Polymorphismes génétiques associés à des troubles cardiovasculaires et à une réponse au médicament, leurs procédes de détection et d'utilisation
Publication
Application
Priority
- EP 04812154 A 20041124
- US 52488203 P 20031126
- US 56821904 P 20040506
Abstract (en)
[origin: WO2005056837A2] The present invention is based on the discovery of genetic polymorphisms that are associated with cardiovascular disorders, particularly acute coronary events such as myocardial infarction and stroke, and genetic polymorphisms that are associated with responsiveness of an individual to treatment of cardiovascular disorders with statin. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods of using the nucleic acid and proteins as well as methods of using reagents for their detection.
IPC 8 full level
A61K 31/22 (2006.01); A61K 31/225 (2006.01); C12Q 1/68 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP US)
A61K 31/22 (2013.01 - EP US); A61K 31/225 (2013.01 - EP US); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 16/28 (2013.01 - US); C12Q 1/6883 (2013.01 - EP US); G01N 33/6893 (2013.01 - EP US); C12Q 2600/106 (2013.01 - EP US); C12Q 2600/136 (2013.01 - EP US); C12Q 2600/156 (2013.01 - EP US); C12Q 2600/158 (2013.01 - US); C12Q 2600/172 (2013.01 - EP US); G01N 2800/32 (2013.01 - EP US); G01N 2800/324 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LU MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2005056837 A2 20050623; WO 2005056837 A3 20061005; CA 2547072 A1 20050623; CA 2547072 C 20150623; CA 2832293 A1 20050623; CA 2832293 C 20150804; CA 2860272 A1 20050623; CA 2860272 C 20171219; CA 2921196 A1 20050623; CA 2921196 C 20190305; CA 2991249 A1 20050623; CA 2991249 C 20200707; CA 3048093 A1 20050623; CA 3050151 A1 20050623; CA 3050151 C 20230307; EP 1711622 A2 20061018; EP 2186913 A2 20100519; EP 2186913 A3 20100915; EP 2186913 B1 20160210; EP 2386656 A2 20111116; EP 2386656 A3 20120208; EP 2386656 B1 20130424; EP 2386657 A2 20111116; EP 2386657 A3 20120314; EP 2386657 B1 20140108; EP 2386658 A2 20111116; EP 2386658 A3 20120314; EP 2386658 B1 20140108; EP 2386659 A2 20111116; EP 2386659 A3 20120307; EP 2386659 B1 20140115; EP 2405023 A2 20120111; EP 2405023 A3 20120314; EP 2405023 B1 20140108; JP 2009519703 A 20090521; JP 2011115168 A 20110616; JP 2014023533 A 20140206; JP 2016026503 A 20160218; JP 2016054738 A 20160421; JP 2017099387 A 20170608; JP 2018046852 A 20180329; JP 2019088298 A 20190613; JP 2020108390 A 20200716; JP 5649263 B2 20150107; JP 6041960 B2 20161214; JP 6211042 B2 20171011; JP 6376612 B2 20180822; JP 6537150 B2 20190703; JP 6749431 B2 20200902; US 10982281 B2 20210420; US 11708610 B2 20230725; US 2005272054 A1 20051208; US 2010190172 A1 20100729; US 2014221484 A1 20140807; US 2017029888 A1 20170202; US 2018305762 A1 20181025; US 2021332434 A1 20211028; US 9932637 B2 20180403
DOCDB simple family (application)
US 2004039576 W 20041124; CA 2547072 A 20041124; CA 2832293 A 20041124; CA 2860272 A 20041124; CA 2921196 A 20041124; CA 2991249 A 20041124; CA 3048093 A 20041124; CA 3050151 A 20041124; EP 04812154 A 20041124; EP 10153674 A 20041124; EP 11177504 A 20041124; EP 11177508 A 20041124; EP 11177511 A 20041124; EP 11177519 A 20041124; EP 11177523 A 20041124; JP 2006541713 A 20041124; JP 2011004344 A 20110112; JP 2013166477 A 20130809; JP 2015204276 A 20151016; JP 2015204277 A 20151016; JP 2016246194 A 20161220; JP 2017233228 A 20171205; JP 2019004206 A 20190115; JP 2020041614 A 20200311; US 201314045416 A 20131003; US 201615168632 A 20160531; US 201815894253 A 20180212; US 202117186574 A 20210226; US 68309910 A 20100106; US 99556104 A 20041124