Global Patent Index - EP 2190985 A4

EP 2190985 A4 20101215 - CANCER-RELATED GENES, CDCA5, EPHA7, STK31 AND WDHD1

Title (en)

CANCER-RELATED GENES, CDCA5, EPHA7, STK31 AND WDHD1

Title (de)

MIT KREBS ASSOZIIERTE GENE CDCA5, EPHA7, STK31 UND WDHD1

Title (fr)

GÈNES SE RAPPORTANT AU CANCER, CDCA5, EPHA7, STK31 ET WDHD1

Publication

EP 2190985 A4 20101215 (EN)

Application

EP 08792792 A 20080821

Priority

  • JP 2008065353 W 20080821
  • US 95793407 P 20070824
  • US 97733507 P 20071003

Abstract (en)

[origin: WO2009028581A1] The invention features methods for detecting cancers, especially lung cancer and/or esophageal cancer, using over-expressed gene; CDCA5, EPHA7, STK31 or WDHD1 compared the normal organs. Also disclosed are methods of identifying compounds for treating and preventing cancers, based on the over-expression or the biological activity of CDCA5, EPHA7, STK31 or WDHD1 in the cancers, especially the interaction between EPHA7 and EGFR. Also, features are a method for treating cancers by administering a double-stranded molecule against CDCA5, EPHA7, STK31 or WDHD1 gene. The invention also features products, including the double-stranded molecules and vectors encoding them, as well as compositions comprising the molecules or vectors, useful in the provided methods.

IPC 8 full level

C12Q 1/68 (2006.01); A61K 31/70 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C12N 15/00 (2006.01)

CPC (source: EP US)

A61K 31/70 (2013.01 - EP US); A61P 35/00 (2017.12 - EP); C12N 15/113 (2013.01 - EP US); C12N 15/1137 (2013.01 - EP US); C12N 15/1138 (2013.01 - EP US); C12Q 1/6886 (2013.01 - EP US); A61K 48/00 (2013.01 - EP US); C12N 2310/14 (2013.01 - EP US); C12Q 2600/118 (2013.01 - EP US); C12Q 2600/136 (2013.01 - EP US)

Citation (search report)

  • [A] WO 2007013671 A2 20070201 - ONCOTHERAPY SCIENCE INC [JP], et al
  • [A] WO 02102310 A2 20021227 - INCYTE GENOMICS INC [US], et al
  • [A] WO 0218575 A2 20020307 - INCYTE GENOMICS INC [US], et al
  • [A] US 2007066616 A1 20070322 - SHAPIRO PAUL [US], et al
  • [XDI] RANKIN SUSANNAH ET AL: "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates", MOLECULAR CELL, vol. 18, no. 2, April 2005 (2005-04-01), pages 185 - 200, XP002608175, ISSN: 1097-2765
  • [ID] DIAZ-MARTINEZ LAURA A ET AL: "Regulation of centromeric cohesion by sororin independently of the APC/C", CELL CYCLE, vol. 6, no. 6, March 2007 (2007-03-01), pages 714 - 724, XP002608173
  • [ID] SCHMITZ JULIA ET AL: "Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase", CURRENT BIOLOGY, vol. 17, no. 7, April 2007 (2007-04-01), pages 630 - 636, XP002608174, ISSN: 0960-9822
  • [X] WEI WEN-HAO ET AL: "Gadolinium texaphyrin-methotrexate conjugates. Towards improved cancer chemotherapeutic agents.", ORGANIC & BIOMOLECULAR CHEMISTRY 21 SEP 2005 LNKD- PUBMED:16132091, vol. 3, no. 18, 21 September 2005 (2005-09-21), pages 3290 - 3296, XP002608176, ISSN: 1477-0520
  • See references of WO 2009028581A1

Citation (examination)

WO 2007013665 A2 20070201 - ONCOTHERAPY SCIENCE INC [JP], et al

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2009028581 A1 20090305; BR PI0816150 A2 20190924; CA 2697517 A1 20090305; CN 101835893 A 20100915; EP 2190985 A1 20100602; EP 2190985 A4 20101215; JP 2010536367 A 20101202; KR 20100075858 A 20100705; RU 2010111135 A 20111027; TW 200922626 A 20090601; US 2011160280 A1 20110630

DOCDB simple family (application)

JP 2008065353 W 20080821; BR PI0816150 A 20080821; CA 2697517 A 20080821; CN 200880113358 A 20080821; EP 08792792 A 20080821; JP 2010521582 A 20080821; KR 20107006483 A 20080821; RU 2010111135 A 20080821; TW 97132064 A 20080822; US 67465908 A 20080821