EP 2196450 A1 20100616 - Process for the preparation of pure diacetylrhein (diacerein)
Title (en)
Process for the preparation of pure diacetylrhein (diacerein)
Title (de)
Verfahren zur Herstellung von reinem Diacethylrein (Diacerein)
Title (fr)
Procédé pour la préparation de diacétylrhéine (diacéréine) pure
Publication
Application
Priority
EP 08305906 A 20081209
Abstract (en)
The present invention is directed to a process for producing pure Diacetylrhein (Diacerein), comprising the transformation of raw Diacerein or raw Rhein, into a water-soluble salt thereof, and then elimination of the impurities by passage through a hydrophobic resin: adsorption of the products, washing and then elution. After acidification of the pure salt of Diacerein or Rhein obtained after the passage through said hydrophobic resin, Diacerein is recovered and dried in a pure form. The invention is also directed to pure Diacerein obtained by the process of the invention, in which the total content of impurities is between 0 and 100 ppm. The invention is also directed to pure Diacerein obtained by the process of the invention, in which the Aloemodine content is less than 100 ppm
IPC 8 full level
C07C 51/47 (2006.01); C07C 66/02 (2006.01); C07C 69/157 (2006.01)
CPC (source: EP)
C07C 51/47 (2013.01); C07C 67/56 (2013.01); C07C 2603/24 (2017.04)
Citation (applicant)
- DE 4120989 A1 19930107 - MADAUS AG [DE]
- DE 120990 C
- WO 9630034 A1 19961003 - WISCONSIN ALUMNI RES FOUND [US]
- EP 0520414 A1 19921230 - MADAUS AG [DE]
- WO 2004050601 A2 20040617 - SYNTECO SPA [IT], et al
- EP 0243968 A2 19871104 - PROTER SPA [IT]
- EP 0754173 B1 19990414 - STEBA BEHEER BV [NL]
Citation (search report)
- [DX] WO 2004050601 A2 20040617 - SYNTECO SPA [IT], et al
- [X] US 6624192 B1 20030923 - CARCASONA ALFONS [DE], et al
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA MK RS
DOCDB simple family (publication)
DOCDB simple family (application)
EP 08305906 A 20081209