Global Patent Index - EP 2196450 A1

EP 2196450 A1 20100616 - Process for the preparation of pure diacetylrhein (diacerein)

Title (en)

Process for the preparation of pure diacetylrhein (diacerein)

Title (de)

Verfahren zur Herstellung von reinem Diacethylrein (Diacerein)

Title (fr)

Procédé pour la préparation de diacétylrhéine (diacéréine) pure

Publication

EP 2196450 A1 20100616 (EN)

Application

EP 08305906 A 20081209

Priority

EP 08305906 A 20081209

Abstract (en)

The present invention is directed to a process for producing pure Diacetylrhein (Diacerein), comprising the transformation of raw Diacerein or raw Rhein, into a water-soluble salt thereof, and then elimination of the impurities by passage through a hydrophobic resin: adsorption of the products, washing and then elution. After acidification of the pure salt of Diacerein or Rhein obtained after the passage through said hydrophobic resin, Diacerein is recovered and dried in a pure form. The invention is also directed to pure Diacerein obtained by the process of the invention, in which the total content of impurities is between 0 and 100 ppm. The invention is also directed to pure Diacerein obtained by the process of the invention, in which the Aloemodine content is less than 100 ppm

IPC 8 full level

C07C 51/47 (2006.01); C07C 66/02 (2006.01); C07C 69/157 (2006.01)

CPC (source: EP)

C07C 51/47 (2013.01); C07C 67/56 (2013.01); C07C 2603/24 (2017.04)

Citation (applicant)

Citation (search report)

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA MK RS

DOCDB simple family (publication)

EP 2196450 A1 20100616

DOCDB simple family (application)

EP 08305906 A 20081209