EP 2198027 A1 20100623 - SHORT POLYPEPTIDE MEDIATED CONFORMATIONAL CHANGES PROMOTING ENHANCEMENT OF ENZYMATIC ACTIVITY
Title (en)
SHORT POLYPEPTIDE MEDIATED CONFORMATIONAL CHANGES PROMOTING ENHANCEMENT OF ENZYMATIC ACTIVITY
Title (de)
DIE VERBESSERUNG ENZYMATISCHER AKTIVITÄT FÖRDENDE, DURCH KURZES POLYPEPTID VERMITTELTE KONFORMATIONSÄNDERUNGEN
Title (fr)
MODIFICATIONS CONFORMATIONNELLES MÉDIÉES PAR DES POLYPEPTIDES COURTS FAVORISANT L'AUGMENTATION D'ACTIVITÉ ENZYMATIQUE
Publication
Application
Priority
- EP 2008062118 W 20080912
- US 96003507 P 20070912
Abstract (en)
[origin: WO2009034159A1] The invention provides for an isolated and purified tagged dimeric protein as well as a process for producing and purifying the same and the use thereof. The present invention also relates to methods and pharmaceutical compositions for the treatment of lysosomal storage diseases. More specifically the invention provides methods and compositions for treating sulfatase deficiency. In particular, the invention relates to methods and compositions for treating sulfatase deficiency diseases caused all or in part by deficiencies in human N-acetylgalactosamine-6-sulfatase (GALNS) including mucopolysaccharidosis IVA (MPS IVA).
IPC 8 full level
C12N 9/16 (2006.01); C12N 15/62 (2006.01)
CPC (source: EP)
C12N 9/16 (2013.01); C07K 2319/00 (2013.01)
Citation (search report)
See references of WO 2009034159A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA MK RS
DOCDB simple family (publication)
DOCDB simple family (application)
EP 2008062118 W 20080912; EP 08804083 A 20080912