Global Patent Index - EP 2200638 B1

EP 2200638 B1 20160316 - COMPOSITIONS FOR THE TRANSFECTION OF CELLS

Title (en)

COMPOSITIONS FOR THE TRANSFECTION OF CELLS

Title (de)

ZUSAMMENSETZUNGEN FÜR DIE TRANSFEKTION VON ZELLEN

Title (fr)

COMPOSITIONS POUR LA TRANSFECTION DES CELLULES

Publication

EP 2200638 B1 20160316 (EN)

Application

EP 08800135 A 20081009

Priority

  • AU 2008001501 W 20081009
  • AU 2007905530 A 20071009
  • AU 2007905536 A 20071009

Abstract (en)

[origin: WO2009046498A1] The present invention relates to the targeted delivery of molecules to cells expressing toll-like receptors (TLRs). Aspects of the invention provide compounds comprising a positively charged group linked to a TLR ligand. These compounds are useful for in vitro and in vivo methods of transfection of TLR-expressing cells. Other aspects of the invention relate to the use of such compounds for repression of gene expression and DNA vaccination approaches.

IPC 8 full level

A61K 39/00 (2006.01); C07K 1/107 (2006.01); C12N 15/87 (2006.01)

CPC (source: EP US)

A61K 39/00 (2013.01 - EP US); A61P 29/00 (2018.01 - EP); A61P 31/04 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 37/04 (2018.01 - EP); A61P 37/06 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07K 1/1075 (2013.01 - EP US); C12N 15/87 (2013.01 - EP US); A61K 2039/53 (2013.01 - EP US); A61K 2039/6018 (2013.01 - EP US); A61K 2039/622 (2013.01 - EP US); C12N 2810/855 (2013.01 - EP US)

Citation (examination)

  • WO 2004014956 A1 20040219 - QUEENSLAND INST MED RES [AU], et al
  • BRENDON Y CHUA ET AL: "Soluble proteins induce strong CD8+ T cell and antibody responses through electrostatic association with simple cationic or anionic lipopeptides that target TLR2", vol. 187, no. 4, 15 August 2011 (2011-08-15), pages 1692 - 1701, XP002681595, ISSN: 0022-1767, Retrieved from the Internet <URL:http://www.jimmunol.org/content/187/4/1692> [retrieved on 20110708], DOI: 10.4049/JIMMUNOL.1100486
  • KIM S. KAWAMURA ET AL: "Probing the Impact of Valency on the Routing of Arginine-Rich Peptides into Eukaryotic Cells +", BIOCHEMISTRY, vol. 45, no. 4, 1 January 2006 (2006-01-01), pages 1116 - 1127, XP055133227, ISSN: 0006-2960, DOI: 10.1021/bi051338e
  • GROS ET AL: "A non-covalent peptide-based strategy for protein and peptide nucleic acid transduction", BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - BIOMEMBRANES, ELSEVIER, AMSTERDAM, NL, vol. 1758, no. 3, 1 March 2006 (2006-03-01), pages 384 - 393, XP005436040, ISSN: 0005-2736, DOI: 10.1016/J.BBAMEM.2006.02.006
  • GARIEPY J ET AL: "Vectorial delivery of macromolecules into cells using peptide-based vehicles", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 19, no. 1, 1 January 2001 (2001-01-01), pages 21 - 28, XP004227647, ISSN: 0167-7799, DOI: 10.1016/S0167-7799(00)01520-1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2009046498 A1 20090416; AU 2008310313 A1 20090416; AU 2008310313 B2 20140807; AU 2008310313 C1 20150212; CA 2702154 A1 20090416; CA 2702154 C 20170516; DK 2200638 T3 20160606; EP 2200638 A1 20100630; EP 2200638 A4 20120321; EP 2200638 B1 20160316; ES 2575395 T3 20160628; JP 2010539992 A 20101224; JP 5743315 B2 20150701; US 2010310595 A1 20101209; US 9089508 B2 20150728

DOCDB simple family (application)

AU 2008001501 W 20081009; AU 2008310313 A 20081009; CA 2702154 A 20081009; DK 08800135 T 20081009; EP 08800135 A 20081009; ES 08800135 T 20081009; JP 2010528245 A 20081009; US 68241508 A 20081009