EP 2201130 A4 20101006 - SENSITIVE AND RAPID METHODS OF USING CHIMERIC RECEPTORS TO IDENTIFY AUTOIMMUNE DISEASE
Title (en)
SENSITIVE AND RAPID METHODS OF USING CHIMERIC RECEPTORS TO IDENTIFY AUTOIMMUNE DISEASE
Title (de)
EMPFINDLICHE UND SCHNELLE VERFAHREN UNTER VERWENDUNG CHIMÄRER REZEPTOREN ZUR IDENTIFIZIERUNG EINER AUTOIMMUNKRANKHEIT
Title (fr)
PROCÉDÉS SENSIBLES ET RAPIDES D'UTILISATION DE RÉCEPTEURS CHIMÉRIQUES POUR IDENTIFIER UNE MALADIE AUTO-IMMUNE
Publication
Application
Priority
- US 2008011027 W 20080924
- US 90618907 A 20071001
- US 20632208 A 20080908
Abstract (en)
[origin: WO2009045292A1] The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays. Such improvements are based upon the superior performance of assays comprising a chimeric TSH receptor in the presence of a glucocorticoid including, but not limited to, dexamethasone.
IPC 8 full level
C12Q 1/66 (2006.01); C12N 15/00 (2006.01)
CPC (source: EP)
C07K 14/4713 (2013.01); G01N 33/564 (2013.01); G01N 2500/10 (2013.01); G01N 2800/046 (2013.01)
Citation (search report)
- [Y] HARAGUCHI KAZUTAKA ET AL: "Functional expression of thyrotropin receptor in differentiated 3T3-L1 cells: A possible model cell line of extrathyroidal expression of thyrotropin receptor", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 223, no. 1, 1996, pages 193 - 198, XP002597291, ISSN: 0006-291X
- [Y] AL-WADEI H A N ET AL: "PKA-dependent growth stimulation of cells derived from human pulmonary adenocarcinoma and small airway epithelium by dexamethasone.", EUROPEAN JOURNAL OF CANCER (OXFORD, ENGLAND : 1990) NOV 2005 LNKD- PUBMED:16239108, vol. 41, no. 17, November 2005 (2005-11-01), pages 2745 - 2753, XP025298198, ISSN: 0959-8049
- [Y] WATSON P F ET AL: "A new chemiluminescent assay for the rapid detection of thyroid stimulating antibodies in Graves' disease", CLINICAL ENDOCRINOLOGY, BLACKWELL SCIENTIFIC PUBLICATIONS, OXFORD, GB LNKD- DOI:10.1046/J.1365-2265.1998.00619.X, vol. 49, 1 November 1998 (1998-11-01), pages 577 - 581, XP002089745, ISSN: 0300-0664
- [Y] EVANS C ET AL: "DEVELOPMENT OF A LUMINESCENT BIOASSAY FOR THYROID STIMULATING ANTIBODIES", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, THE ENDOCRINE SOCIETY, US LNKD- DOI:10.1210/JC.84.1.374, vol. 84, no. 1, 1 January 1999 (1999-01-01), pages 374 - 377, XP000943995, ISSN: 0021-972X
- [Y] YAMASHIRO K ET AL: "MECHANISM OF THE AUGMENTATIVE EFFECT OF HIGH POLYETHYLENE GLYCOL (PEG) CONCENTRATIONS ON THE THYROID STIMULATING ACTIVITY IN TSAB-IGG USING A PORCINE THYROID CELL ASSAY", ENDROCRINE RESEARCH, MARCEL DEKKER, NEW YORK, NY, US, vol. 25, no. 1, 1 January 1999 (1999-01-01), pages 67 - 75, XP009009910, ISSN: 0743-5800
- See references of WO 2009045292A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA MK RS
DOCDB simple family (publication)
WO 2009045292 A1 20090409; AU 2008307735 A1 20090409; AU 2008307735 B2 20140424; CA 2701198 A1 20090409; CA 2701198 C 20150721; CN 101918585 A 20101215; EP 2201130 A1 20100630; EP 2201130 A4 20101006; JP 2010539975 A 20101224; JP 5474802 B2 20140416; KR 101560849 B1 20151120; KR 20100101072 A 20100916
DOCDB simple family (application)
US 2008011027 W 20080924; AU 2008307735 A 20080924; CA 2701198 A 20080924; CN 200880115000 A 20080924; EP 08835584 A 20080924; JP 2010527945 A 20080924; KR 20107009641 A 20080924