EP 2203460 A4 20120314 - BISPHOSPHONATE COMPOUNDS AND METHODS WITH ENHANCED POTENCY FOR MULTIPLE TARGETS INCLUDING FPPS, GGPPS, AND DPPS
Title (en)
BISPHOSPHONATE COMPOUNDS AND METHODS WITH ENHANCED POTENCY FOR MULTIPLE TARGETS INCLUDING FPPS, GGPPS, AND DPPS
Title (de)
BIPHOSPHONAT-VERBINDUNGEN UND VERFAHREN MIT ERHÖHTER POTENZ FÜR MEHRERE ZIELE, DARUNTER FPPS, GGPPS UND DPPS
Title (fr)
COMPOSÉS BISPHOSPHONATES ET PROCÉDÉS PRÉSENTANT UN POTENTIEL AMÉLIORÉ POUR CIBLES MULTIPLES INCLUANT FPPS, GGPPS, ET DPPS
Publication
Application
Priority
- US 2008060051 W 20080411
- US 91142607 P 20070412
Abstract (en)
[origin: CA2682694A1] The disclosure provides, inter alia, novel bisphosphonate compounds and m ethods of making and using such compounds. In certain embodiments, compounds of the invention include bisphosphonates that are capable of selectively in hibiting one or more of farnesyl diphosphate synthase (FPPS), geranylgeranyl diphosphate synthase (GGPPS), and decaprenyl pyrophosphate synthase (DPPS). In preferred embodiments, compounds of the invention are capable of selecti vely inhibiting two or more of FPPS, GGPPS, and DPPS. In embodiments, compou nds and methods of the invention demonstrate superior activity levels, such as in the anti-cancer context, immunostimulation context, and other contexts , which in several cases exceed the activity levels of previous generation b isphosphonate drugs by orders of magnitude. In embodiments, the invention pr ovides compounds and methods in connection with research and therapeutic app lications, e.g., for tumor or cancer cell growth inhibition, activation of g ammadelta T cells, inhibition of certain enzymes related to the mevalonate m etabolic pathway, bone resorption diseases, cancer, immune disorders, immuno therapy, and infectious diseases.
IPC 8 full level
C07F 9/576 (2006.01); C07F 9/6503 (2006.01)
CPC (source: EP)
C07F 9/3839 (2013.01); C07F 9/3865 (2013.01); C07F 9/3873 (2013.01); C07F 9/3878 (2013.01); C07F 9/5532 (2013.01); C07F 9/58 (2013.01); C07F 9/59 (2013.01); C07F 9/6506 (2013.01); C07F 9/6539 (2013.01); C07F 9/65517 (2013.01); C07F 9/655345 (2013.01); C07F 9/65583 (2013.01); C07F 9/6561 (2013.01); C07F 9/72 (2013.01); C12Q 1/48 (2013.01); G01N 2333/91171 (2013.01)
Citation (search report)
- [XI] US 2006079487 A1 20060413 - SANDERS JOHN M [US], et al
- [X] ZHANG Y ET AL: "Activity of Nitrogen-Containing and Non-Nitrogen-Containing Bisphosphonates on Tumor Cell Lines", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 49, no. 19, 21 September 2006 (2006-09-21), pages 5804 - 5814, XP008122775, ISSN: 0022-2623, [retrieved on 20060824], DOI: 10.1021/JM060280E
- See references of WO 2008128056A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
AU 2008240266 A1 20081023; CA 2682694 A1 20081023; CN 101679466 A 20100324; EP 2203460 A1 20100707; EP 2203460 A4 20120314; JP 2010523709 A 20100715
DOCDB simple family (application)
AU 2008240266 A 20080411; CA 2682694 A 20080411; CN 200880019104 A 20080411; EP 08780519 A 20080411; JP 2010503237 A 20080411