EP 2205756 A2 20100714 - METHODS OF IDENTIFYING MODULATORS OF AN EHD POLYPEPTIDE
Title (en)
METHODS OF IDENTIFYING MODULATORS OF AN EHD POLYPEPTIDE
Title (de)
VERFAHREN ZUR IDENTIFIZIERUNG VON MODULATOREN EINES EHD-POLYPEPTIDS
Title (fr)
PROCÉDÉS
Publication
Application
Priority
- GB 2008003355 W 20081001
- GB 0719252 A 20071003
Abstract (en)
[origin: GB2453341A] A method of identifying a modulator of an epsin homology domain (EHD) containing polypeptide, said method comprising: providing a first and second sample of an EHD polypeptide; contacting said first sample with a candidate modulator; contacting said first and second samples with ATP; and monitoring ATP hydrolysis in said first and second samples, wherein a difference between the ATP hydrolysis in said first and second samples identifies said candidate modulator as a modulator of an EHD family polypeptide. Also claimed are crystal structures comprising EHD family polypeptides bound to an adenosine nucleotide, methods of identifying therapeutic agents using said crystal structures, an EHD polypeptide, use of EHD family polypeptides in membrane modulation and mutated EHD family polypeptides.
IPC 8 full level
C12Q 1/00 (2006.01); G06F 19/00 (2006.01)
CPC (source: EP GB)
C12N 9/14 (2013.01 - GB); C12N 9/16 (2013.01 - EP); C12Q 1/34 (2013.01 - GB); C12Q 1/42 (2013.01 - EP); C07K 2299/00 (2013.01 - EP); G01N 2333/916 (2013.01 - EP)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA MK RS
DOCDB simple family (publication)
GB 0719252 D0 20071114; GB 2453341 A 20090408; GB 2453341 B 20100825; EP 2205756 A2 20100714; WO 2009044156 A2 20090409; WO 2009044156 A3 20090723
DOCDB simple family (application)
GB 0719252 A 20071003; EP 08806500 A 20081001; GB 2008003355 W 20081001