EP 2208796 A2 20100721 - Polypeptides having nucleic acid binding activity and compositions and methods for nucleic acid amplification
Title (en)
Polypeptides having nucleic acid binding activity and compositions and methods for nucleic acid amplification
Title (de)
Polypeptide mit Nukleinsäurebindungsaktivität und Zusammensetzungen und Verfahren zur Nukleinsäurenamplifikation
Title (fr)
Polypeptides dotées d'une activité de liaison d'acide nucléique et compositions et procédés pour amplification d'acide nucléique
Publication
Application
Priority
- EP 06717401 A 20060106
- US 64198705 P 20050106
- US 69997505 P 20050715
Abstract (en)
Polypeptides having nucleic acid binding activity are provided. Methods of using polypeptides having nucleic acid binding activity are provided. Fusion proteins and methods of using fusion proteins are provided. Fusion proteins comprising a polymerase and a nucleic acid binding polypeptide are provided. Fusion proteins comprising a reverse transcriptase and a nucleic acid binding polypeptide are provided. Methods are provided for amplifying a nucleic acid sequence using a fusion protein comprising a nucleic acid binding polypeptide and a polymerase. Methods are provided for amplifying a nucleic acid sequence using a fusion protein comprising a nucleic acid binding polypeptide and a reverse transcriptase.
IPC 8 full level
C12Q 1/68 (2006.01); C07K 14/195 (2006.01); C12N 9/12 (2006.01); C12N 15/62 (2006.01)
CPC (source: EP US)
C07K 14/195 (2013.01 - EP US); C12N 9/1252 (2013.01 - EP US); C12N 9/96 (2013.01 - US); C12P 19/34 (2013.01 - US); C12Q 1/6813 (2013.01 - EP US); C12Q 1/6844 (2013.01 - EP US); C12Q 1/6846 (2013.01 - EP US); C07K 2319/71 (2013.01 - EP US); C07K 2319/80 (2013.01 - EP US)
C-Set (source: EP US)
Citation (applicant)
- US 4683195 A 19870728 - MULLIS KARY B [US], et al
- US 4683202 A 19870728 - MULLIS KARY B [US]
- US 4800159 A 19890124 - MULLIS KARY B [US], et al
- US 6143877 A 20001107 - MEYER RICH B [US], et al
- US 6127121 A 20001003 - MEYER JR RICH B [US], et al
- WO 0138584 A2 20010531 - EPOCH BIOSCIENCES INC [US]
- WO 9822489 A1 19980528 - IMANISHI TAKESHI [JP]
- WO 9839352 A1 19980911 - IMANISHI TAKESHI [JP], et al
- WO 9914226 A2 19990325 - EXIQON A S [DK], et al
- WO 9220702 A1 19921126 - BUCHARDT OLE [DK], et al
- US 5719262 A 19980217 - BUCHARDT OLE [DK], et al
- US 5698685 A 19971216 - SUMMERTON JAMES E [US], et al
- US 5378841 A 19950103 - SUMMERTON JAMES E [US], et al
- US 5185144 A 19930209 - KOSLO RANDY [US], et al
- US 5470967 A 19951128 - HUIE EDWARD M [US], et al
- US 5817781 A 19981006 - SWAMINATHAN SUNDARAMOORTHI [US], et al
- US 5188934 A 19930223 - MENCHEN STEVEN M [US], et al
- US 6008379 A 19991228 - BENSON SCOTT CONRAD [US], et al
- US 6020481 A 20000201 - BENSON SCOTT C [US], et al
- US 5366860 A 19941122 - BERGOT B JOHN [US], et al
- US 5847162 A 19981208 - LEE LINDA [US], et al
- US 5936087 A 19990810 - BENSON SCOTT C [US], et al
- US 6051719 A 20000418 - BENSON SCOTT CONRAD [US], et al
- US 6191278 B1 20010220 - LEE LINDA G [US], et al
- US 6140500 A 20001031 - YAN XIONGWEI [US], et al
- US 5863727 A 19990126 - LEE LINDA G [US], et al
- US 5800996 A 19980901 - LEE LINDA G [US], et al
- US 5945526 A 19990831 - LEE LINDA G [US], et al
- WO 9745539 A1 19971204 - KUBISTA MIKAEL [SE], et al
- US 5990479 A 19991123 - WEISS SHIMON [US], et al
- US 6207392 B1 20010327 - WEISS SHIMON [US], et al
- US 2003022162 A1 20030130 - HATAKEYAMA KAZUHISA [US]
- US 5795762 A 19980818 - ABRAMSON RICHARD D [US], et al
- US 5466591 A 19951114 - ABRAMSON RICHARD D [US], et al
- US 6795762 B2 20040921 - ITOH AKIRA [JP], et al
- US 5436149 A 19950725 - BARNES WAYNE M [US]
- US 2003228616 A1 20031211 - AREZI BAHRAM [US], et al
- US 6333183 B1 20011225 - EVANS STEVEN [GB], et al
- EP 0745676 B1 20030716 - AMERSHAM BIOSCIENCES CORP [US]
- US 5614365 A 19970325 - TABOR STANLEY [US], et al
- US 6265193 B1 20010724 - BRANDIS JOHN [US], et al
- WO 0114568 A1 20010301 - AMERSHAM PHARM BIOTECH INC [US], et al
- US 2004005573 A1 20040108 - FULLER CARL [US], et al
- EP 1154017 A1 20011114 - TOYO BOSEKI [JP]
- US 2003092018 A1 20030515 - CHATTERJEE DEB K [US], et al
- US 2003162201 A1 20030828 - CHATTERJEE DEB K [US], et al
- US 5834285 A 19981110 - COMB DONALD G [US], et al
- US 6489150 B1 20021203 - MATHUR ERIC J [US]
- US 6673585 B1 20040106 - QUERELLOU JOEL [FR], et al
- US 5948666 A 19990907 - CALLEN WALTER [US], et al
- US 6492511 B2 20021210 - CALLEN WALTER [US], et al
- EP 0547359 B1 20020327 - NEW ENGLAND BIOLABS INC [US]
- US 2004219558 A1 20041104 - VANDER HORN PETER B [US], et al
- WO 0055307 A2 20000921 - UNIV MCGILL [CA], et al
- US 5972603 A 19991026 - BEDFORD ELLA [US], et al
- US 6787338 B2 20040907 - WITTWER CARL T [US], et al
- US 6472186 B1 20021029 - QUINTANAR ANDRE [US], et al
- US 6180372 B1 20010130 - FRANZEN JOCHEN [DE]
- US 6640891 B1 20031104 - OLDENBURG KEVIN R [US]
- US 6482615 B2 20021119 - TAL MICHAEL [IL], et al
- US 6271024 B1 20010807 - SVE CHARLES [US], et al
- US 6814934 B1 20041109 - HIGUCHI RUSSELL GENE [US]
- US 6174670 B1 20010116 - WITTWER CARL T [US], et al
- US 6569627 B2 20030527 - WITTWER CARL T [US], et al
- US 6183997 B1 20010206 - HOGREFE HOLLY [US]
- US 6270967 B1 20010807 - WHITCOMBE DAVID MARK [GB], et al
- US 2003207266 A1 20031106 - CHEN CAIFU [US], et al
- US 5538848 A 19960723 - LIVAK KENNETH J [US], et al
- US 5118801 A 19920602 - LIZARDI PAUL M [MX], et al
- US 5312728 A 19940517 - LIZARDI PAUL M [US], et al
- US 5925517 A 19990720 - TYAGI SANJAY [US], et al
- US 5773258 A 19980630 - BIRCH DAVID EDWARD [US], et al
- US 5677152 A 19971014 - BIRCH DAVID EDWARD [US], et al
- US 6183998 B1 20010206 - IVANOV IGOR [DE], et al
- US 6183967 B1 20010206 - JAYASENA SUMEDHA [US], et al
- US 6020130 A 20000201 - GOLD LARRY [US], et al
- US 5874557 A 19990223 - GOLD LARRY [US], et al
- US 5763173 A 19980609 - GOLD LARRY [US], et al
- US 5693502 A 19971202 - GOLD LARRY [US], et al
- US 6333159 B1 20011225 - BARNES WAYNE M [US], et al
- US 6316202 B1 20011113 - BARNES WAYNE M [US], et al
- US 6214557 B1 20010410 - BARNES WAYNE M [US], et al
- PEREIRA ET AL., PROC. NAT'I ACAD. SCI. USA, vol. 94, 1997, pages 12633 - 12637
- MOTZ ET AL., J. BIOL. CHEM., vol. 277, 2002, pages 16179 - 16188
- FITZ-GIBBON ET AL., PROC. NAT'L ACAD. SCI. USA., vol. 99, 2002, pages 984 - 989
- GUAGIIARDI ET AL., J. MOL. BIOL., vol. 267, 1997, pages 841 - 848
- SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS, pages: 9.63 - 9.75
- MAI ET AL., J. BACTERIOL., vol. 180, 1998, pages 2560 - 2563
- LAWYER ET AL., J. BIOL. CHEM., vol. 264, 1989, pages 6427 - 647
- TATUSOVA, FEMS MICROBIAL LETT., vol. 174, 1999, pages 247 - 250
- TATUSOVA ET AL., FEMS MICROBIOL LETT., vol. 174, 1999, pages 247 - 250
- RYCHLIK ET AL., NUCLEIC ACIDS RES., vol. 18, 1990, pages 6409 - 6412
- SANTALUCIA, PROC. NATL ACAD. SCI. USA, vol. 95, 1998, pages 1460 - 1465
- FASMAN: "Practical Handbook of Biochemistry and Molecular Biologv", 1989, CRC PRESS, pages: 385 - 394
- GARBESI, NUCL. ACIDS RES., vol. 21, 1993, pages 4159 - 65
- FUJIMORI, J. AMER. CHEM. SOC., vol. 112, 1990, pages 7435
- URATA, NUCLEIC ACIDS SYMPOSIUM, vol. 29, 1993, pages 69 - 70
- KOMBERG; BAKER: "DNA Replication", 1992, FREEMAN
- SHABAROVA, Z.; BOGDANOV, A.: "Advanced Orqanic Chemistry of Nucleic Acids", 1994, VCH
- NIELSEN ET AL., SCIENCE, vol. 254, 1991, pages 1497 - 1500
- STIRCHAK; SUMMERTON, J. ORG. CHEM, vol. 52, 1987, pages 4202
- VASSEUR ET AL., J. AM. CHEM. SOC., vol. 114, 1992, pages 4006
- JONES ET AL., J. ORQ. CHEM., vol. 58, 1993, pages 2983
- NIELSEN, SCIENCE, vol. 254, 1991, pages 1497 - 1500
- FRIER; ALTMAN, NUCL. ACIDS RES., vol. 25, 1997, pages 4429
- KRICKA, L.: "Nonisotopic DNA Probe Techniques", 1992, ACADEMIC PRESS, pages: 3 - 28
- HAN ET AL., NATURE BIOTECH., vol. 19, 2001, pages 631 - 635
- MEDINTZ ET AL., NAT. MAT., vol. 4, 2005, pages 435 - 446
- HERMANSON: "Bioconjugate Techniques", 1996, ACADEMIC PRESS
- BEAUCAGE ET AL.: "Current Protocols in Nucleic Acid Chemistry", 2000, JOHN WILEY & SONS
- GARMAN: "Non-Radioactive Labellinq, A Practical lntroduction", 1997, ACADEMIC PRESS
- GAO ET AL., NATURE STRUCT. BIOT., vol. 5, 1998, pages 782 - 786
- ROBINSON ET AL., NATURE, vol. 392, 1998, pages 202 - 205
- MCAFEE ET AL., BIOCHEM., vol. 34, 1995, pages 10063 - 10077
- BAUMANN ET AL., NATURE STRUCT. BIOL., vol. 1, 1994, pages 808 - 819
- GAO ET AL., NATURE STRUCT. BIOL., vol. 5, 1998, pages 782 - 786
- ROBINSON ET AL., NATURE, vol. 392, 1998, pages 202 - 205
- GUAGLIARDI ET AL., J. MOL. BIOL., vol. 267, 1997, pages 841 - 848
- GUAGLIARDI, J. MOL. BIOL., vol. 267, 1997, pages 841 - 848
- SHEHI ET AL., BIOCHEM., vol. 42, 2003, pages 8362 - 8368
- SAMBROOK ET AL.: "Molecular Cioninq: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
- FITZ-GIBBON ET AL., PROC. NAT'L ACAD. SCI. USA, vol. 99, 2002, pages 984 - 989
- KAWARABAYASI, DNA RESEARCH, 1999, pages 145 - 152
- SHE ET AL., PROC. NAT'L ACAD. SCI. USA, vol. 98, 2001, pages 7835 - 7840
- STEMMER ET AL., GENE, vol. 164, 1995, pages 49 - 53
- GRONLUND, J. BIOL. CHEM., vol. 278, 2003, pages 40144 - 40151
- AUSUBEL ET AL.: "Current Protocol in Molecular Biologly", 1991, JOHN WILEY & SONS
- BUNING ET AL., ANAL. BLOCHEM., vol. 234, 1996, pages 227 - 230
- ITO ET AL., NUCLEIC ACIDS RES, vol. 19, 1991, pages 4045 - 4057
- BRAITHWAITE ET AL., NUCLEIC ACIDS RES., vol. 21, 1993, pages 787 - 802
- FILEÉ ET AL., J. MOL. EVOL., vol. 54, 2002, pages 763 - 773
- ALBÀ, GENOME BIOL., vol. 2, 2001, pages 30021 - 30024
- PAVLOV ET AL., TRENDS IN BIOTECH., vol. 22, 2004, pages 253 - 260
- STEITZ, J. BIOL. CHEM., vol. 274, 1999, pages 17395 - 17398
- LAWYER ET AL., J. BIOL. CHEM., vol. 264, 1989, pages 6427 - 6437
- VAINSHTEIN ET AL., PROTEIN SCIENCE, vol. 5, 1996, pages 1785 - 1792
- BAMES, GENE, vol. 112, 1992, pages 29 - 35
- KAHLER ET AL., J. BACTERIOL., vol. 182, 2000, pages 655 - 663
- SOUTHWORTH, PRBC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 5281 - 5285
- DERBYSHIRE ET AL., METHODS ENZVMOL., vol. 262, 1995, pages 363 - 388
- SOUTHWORTH ET AL., PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 5281 - 5285
- KONG ET AL., J. BIOL. CHEM., vol. 268, 1993, pages 1965 - 197
- WALSH, NUCLEIC ACIDS RES., vol. 24, 1996, pages 2807 - 2812
- KUROITA ET AL., J. MOL. BIOL., vol. 351, 2005, pages 291 - 298
- BOHIKE, NUCL. ACID RES., vol. 28, 2000, pages 3910 - 3917
- SAMBROOK: "Molecular Cloninq: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS, pages: 810 - 811
- IGNATOV ET AL., FEBS LETTERS, vol. 425, 1999, pages 249 - 250
- IGNATOV ET AL., FEBS LETTERS, vol. 448, pages 145 - 148
- TAKAGI ET AL., APPL. ENVIRON. MICROBIOL., vol. 63, 1997, pages 4504 - 4510
- SHUTTLEWORTH ET AL., J. MOLEC. BIOI., vol. 337, 2004, pages 621 - 634
- FOGG ET AL., NATURE STRUCT. BIOL., vol. 9, 2002, pages 922 - 927
- SHANDILYA ET AL., EXTREMOPHILES, vol. 8, 2004, pages 243 - 251
- TELESNITSKY ET AL., PROC_ NATL. ACAD. SCI. USA, vol. 90, 1993, pages 1276 - 1280
- ITO ET AL., NUC. ACIDS. RESEARCH, vol. 19, 1991, pages 4045 - 4057
- BRAITHWAITE ET AL., NUC. ACIDS. 'RESEARCH, vol. 21, 1993, pages 787 - 802
- FILEÉ ET AL., J. MOL. EVOL., vol. 54, 2002, pages 763 - T73
- AUSUBEL ET AL.: "Current Protocols in Molecular Bioloqy", 1991, JOHN WILEY & SONS
- BUNING, ANAL. BIOCHEM., vol. 234, 1996, pages 227 - 230
- "Bioconiuaate Technlaues", 1996, ACADEMIC PRESS
- CRASTO ET AL., PROTEIN ENG., vol. 13, 2000, pages 309 - 312
- BLAIN ET AL., J. BIOL. CHEM., vol. 31, 1993, pages 23585 - 23592
- SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS, pages: 6.33 - 6.58
- BRISELDEN ET AL., J. CLIN. MICROBLOL., vol. 32, 1994, pages 148 - 52
- WITT ET AL., J. CLIN. MICROBIOL., vol. 40, 2002, pages 3057 - 3059
- SHI, CLINICAL CHEM., vol. 47, 2001, pages 164 - 172
- SAMBROOK ET AL.: "Molecular Cloning: A Laboratorr Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS, pages: 8.22
- SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS, pages: 8110
- KELLOGG ET AL., BIOTECHNIQUES, vol. 16, 1994, pages 1134 - 1137
- SAMBROOK ET AL.: "Molecular Cloninq: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS, pages: 8.110
- SAMBROOK ET AL.: "Molecular Cloning: A Laborstory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS, pages: 8.18 - 8.24
- INNIS ET AL.: "PCR Protocols: A Guide to Methods and Applications", 1990, ACADEMIC PRESS
- SAMBROOK: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS, pages: 8.22
- MOORE, NATURE, vol. 435, 2005, pages 235 - 238
- CONSTANS, THE SCIENTIST, vol. 15, no. 24, 10 December 2001 (2001-12-10), pages 1 - 7
- PRITHAM ET AL., J. CLIN. LIGAND ASSAY, vol. 21, 1998, pages 404 - 412
- AREZI ET AL., ANALVTICAL BIOCHEM., vol. 321, 2003, pages 226 - 235
- SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS, pages: 8.9
- LIN ET AL., PROC. NAT'L ACAD. SCI. USA, vol. 93, 1996, pages 2582 - 2587
- "Real-Time PCR. an Essential Guide", 2004, HORIZON BIOSCIENCE
- KAISER ET AL., J. BIOL. CHEM., vol. 274, 1999, pages 21387 - 21394
- SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS, pages: 8.95
- LIVAK ET AL., PCR METHODS APPL, vol. 4, 1995, pages 357 - 362
- HEID ET AL., GENOME RES., vol. 6, 1996, pages 986 - 994
- AFONINA ET AL., BIOTECHNIQUES, vol. 32, 2002, pages 940 - 44,946-49
- WHITCOMBE ET AL., NAT. BIOTECHNOL., vol. 17, 1999, pages 804 - 807
- SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS, pages: 8.110
- KERMEKCHIEV, NUCLEIC ACIDS RES., vol. 31, 2003, pages 6139 - 6147
- SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR - LABORATORY PRESS, pages: 1251 - 1260,129
- WANG ET AL., NUC. ACIDS RES., vol. 32, 2004, pages 1197 - 1207
- GUAGLIARDI ET AL., J. MOL. BIOF., vol. 267, 1997, pages 841 - 848
- WANG ET AL., NUC: ACIDS RES., vol. 32, 2004, pages 1197 - 1207
- KAMASHEV ET AL., EMBO J., vol. 19, no. 23, 2000, pages 6527 - 6535
- GUAGLIARDI ET AL., J. MOL. BIOL., vol. 267, no. 4, 1997, pages 841 - 848
- MCAFEE ET AL., BIOCHEMISTRY, vol. 34, no. 31, 1995, pages 10063 - 10077
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2006074233 A2 20060713; WO 2006074233 A3 20070405; AU 2006204006 A1 20060713; EP 1836319 A2 20070926; EP 1836319 B1 20120919; EP 2208796 A2 20100721; EP 2208796 A3 20101103; EP 2208796 B1 20140618; EP 2813581 A1 20141217; EP 2813581 B1 20180627; US 2006228726 A1 20061012; US 2010159527 A1 20100624; US 2013089895 A1 20130411; US 2016194678 A1 20160707; US 9267130 B2 20160223
DOCDB simple family (application)
US 2006000191 W 20060106; AU 2006204006 A 20060106; EP 06717401 A 20060106; EP 09016058 A 20060106; EP 14172370 A 20060106; US 201213613476 A 20120913; US 201614990318 A 20160107; US 32784506 A 20060106; US 54578209 A 20090821