Global Patent Index - EP 2219645 A2

EP 2219645 A2 20100825 - USE OF CRTH2 ANTAGONIST COMPOUNDS

Title (en)

USE OF CRTH2 ANTAGONIST COMPOUNDS

Title (de)

VERWENDUNG VON CRTH2-ANTAGONISTEN-VERBINDUNGEN

Title (fr)

UTILISATION DE COMPOSÉS ANTAGONISTES DE CRTH2

Publication

EP 2219645 A2 20100825 (EN)

Application

EP 08851028 A 20081113

Priority

  • GB 2008003824 W 20081113
  • GB 0722203 A 20071113

Abstract (en)

[origin: WO2009063202A2] The invention relates to compounds of general formula (I) wherein R1, R2, R3, R4 and R5 are as defined herein for the treatment of allergic conditions, wherein the treatment is by pulsed therapy which comprises a first period during which the compound is administered to the patient and a second period of at least seven days during which the compound is administered to the patient in a reduced amount.

IPC 8 full level

A61K 31/404 (2006.01); A61K 31/405 (2006.01); A61K 31/4439 (2006.01); A61K 31/4709 (2006.01); A61K 45/06 (2006.01); A61P 11/06 (2006.01); A61P 17/00 (2006.01); A61P 27/14 (2006.01); A61P 37/08 (2006.01)

CPC (source: EP)

A61K 31/405 (2013.01); A61K 31/416 (2013.01); A61K 31/427 (2013.01); A61K 31/4439 (2013.01); A61K 31/4709 (2013.01); A61K 31/498 (2013.01); A61K 45/06 (2013.01); A61P 11/02 (2017.12); A61P 11/06 (2017.12); A61P 17/00 (2017.12); A61P 27/14 (2017.12); A61P 37/08 (2017.12); A61P 43/00 (2017.12)

Citation (search report)

See references of WO 2009063202A2

Citation (examination)

  • VAN HECKEN A ET AL: "The effect of MK-0524, a prostaglandin D2 receptor antagonist, on prostaglandin D2-induced nasal airway obstruction in healthy volunteers", EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, SPRINGER, BERLIN, DE, vol. 63, no. 2, 3 January 2007 (2007-01-03), pages 135 - 141, XP019472240, ISSN: 1432-1041, DOI: 10.1007/S00228-006-0211-2
  • STUEBNER P ET AL: "Effects of rupatadine vs placebo on allergen-induced symptoms in patients exposed to aeroallergens in the Vienna Challenge Chamber", ANNALS OF ALLERGY, ASTHMA & IMMUNOLOGY, ARLINGTON HEIGHTS, IL, US, vol. 96, no. 1, 1 January 2006 (2006-01-01), pages 37 - 44, XP026959389, ISSN: 1081-1206, [retrieved on 20060101]
  • HORAK F ET AL: "Comparison of the effects of desloratadine 5-mg daily and placebo on nasal airflow and seasonal allergic rhinitis symptoms induced by grass pollen exposure.", ALLERGY (COPENHAGEN), vol. 58, no. 6, June 2003 (2003-06-01), pages 481 - 485, XP055032188, ISSN: 0105-4538
  • HORAK F ET AL: "The CRTH2 antagonist OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial.", ALLERGY DEC 2012, vol. 67, no. 12, December 2012 (2012-12-01), pages 1572 - 1579, ISSN: 1398-9995

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA MK RS

DOCDB simple family (publication)

WO 2009063202 A2 20090522; WO 2009063202 A3 20090827; DE 08851028 T1 20110224; EP 2219645 A2 20100825; ES 2353055 T1 20110225; GB 0722203 D0 20071219; JP 2011503045 A 20110127

DOCDB simple family (application)

GB 2008003824 W 20081113; DE 08851028 T 20081113; EP 08851028 A 20081113; ES 08851028 T 20081113; GB 0722203 A 20071113; JP 2010532660 A 20081113