EP 2221315 A1 20100825 - Methods of generating variant proteins with increased host string content and compositions thereof

Title (en)

Methods of generating variant proteins with increased host string content and compositions thereof

Title (de)

Verfahren zur Erzeugung von Proteinvarianten mit erhöhtem Wirtsstranginhalt und Zusammensetzungen davon

Title (fr)

Procédés de génération de protéines variantes avec un contenu amélioré de fil hôte et compositions associées

Publication

EP 2221315 A1 20100825 (EN)

Application

EP 10004410 A 20041203

Priority

EP 04813075 A 20041203
US 52716703 P 20031204
US 58161304 P 20040621
US 60166504 P 20040813
US 61948304 P 20041016

Abstract (en)

The present invention relates to novel methods for generating variant proteins with increased host string content, and proteins that are engineered using these methods.

IPC 8 full level

C07K 16/00 (2006.01); C07K 16/28 (2006.01); G01N 33/48 (2006.01); G16B 20/20 (2019.01); G16B 20/30 (2019.01); G16B 20/50 (2019.01); G16B 30/10 (2019.01)

IPC 8 main group level

C12N (2006.01)

CPC (source: EP US)

C07K 16/00 (2013.01 - EP US); C07K 16/2863 (2013.01 - EP US); C07K 16/2878 (2013.01 - EP US); G16B 20/20 (2019.01 - EP US); G16B 20/30 (2019.01 - EP US); G16B 20/50 (2019.01 - EP US); G16B 30/00 (2019.01 - EP US); G16B 30/10 (2019.01 - EP US); C07K 2317/24 (2013.01 - EP US); C07K 2317/567 (2013.01 - EP US); C07K 2317/72 (2013.01 - EP US); C07K 2317/732 (2013.01 - EP US); C07K 2317/76 (2013.01 - EP US); C07K 2317/92 (2013.01 - EP US); G16B 20/00 (2019.01 - EP US)

Citation (applicant)

US 5225539 A 19930706 - WINTER GREGORY P [GB]
US 5530101 A 19960625 - QUEEN CARY L [US], et al
US 5585089 A 19961217 - QUEEN CARY L [US], et al
US 5693761 A 19971202 - QUEEN CARY L [US], et al
US 5693762 A 19971202 - QUEEN CARY L [US], et al
US 6180370 B1 20010130 - QUEEN CARY L [US], et al
US 5859205 A 19990112 - ADAIR JOHN ROBERT [GB], et al
US 5821337 A 19981013 - CARTER PAUL J [US], et al
US 6054297 A 20000425 - CARTER PAUL J [US], et al
US 6407213 B1 20020618 - CARTER PAUL J [US], et al
US 5712120 A 19980127 - RODRIQUEZ ROLANDO PEREZ [CU], et al
US 2003153043 A1 20030814 - CARR FRANCIS JOSEPH [GB], et al
US 67228003 A 20030926
US 0330249 W 20030926
US 82223104 A 20040326
US 62777404 P 20041112
US 6737056 B1 20040518 - PRESTA LEONARD [US]
US 2004000643 W 20040109
US 37074903 A 20030220
US 2004005112 W 20040220
US 2004132101 A1 20040708 - LAZAR GREGORY ALAN [US], et al
US 67228003 A 20030926
US 2004002587 A1 20040101 - WATKINS JEFFRY D [US], et al
WO 2004063351 A2 20040729 - MACROGENICS INC [US], et al
US 6602684 B1 20030805 - UMANA PABLO [GB], et al
US 27737002 A 20021022
US 11392902 A 20020402
WO 0061739 A1 20001019 - KYOWA HAKKO KOGYO KK [JP], et al
WO 0129246 A1 20010426 - KYOWA HAKKO KOGYO KK [JP], et al
WO 0231140 A1 20020418 - KYOWA HAKKO KOGYO KK [JP]
WO 0230954 A1 20020418 - KYOWA HAKKO KOGYO KK [JP]
US 52822903 P 20031208
US 60256604 P 20040817
US 6188965 B1 20010213 - MAYO STEPHEN L [US], et al
US 6269312 B1 20010731 - MAYO STEPHEN L [US], et al
US 6403312 B1 20020611 - DAHIYAT BASSIL I [US], et al
US 6708120 B1 20040316 - MAYO STEPHEN L [US], et al
US 6804611 B2 20041012 - MAYO STEPHEN L [US], et al
US 6792356 B2 20040914 - MAYO STEPHEN L [US], et al
US 78200401 A 20010212
US 81203401 A 20010319
US 92779001 A 20010810
US 21810202 A 20020812
US 10149901 A
US 66631103 A 20030918
US 66530703 A 20030918
US 88874804 A 20040709
WO 9807254 A1 19980219 - UNIV DUNDEE [GB], et al
WO 9924229 A1 19990520 - HENKEL CORP [US], et al
WO 0140091 A1 20010607 - KOENIG & BAUER AG [DE], et al
WO 0225588 A2 20020328 - MD ONLINE INC [US], et al
US 87769501 A 20010608
US 7185902 A 20020206
US 33978803 A 20030108
WO 9852976 A1 19981126 - BIOVATION LTD [GB], et al
WO 02079232 A2 20021010 - LEXIGEN PHARM CORP [US]
WO 0034317 A2 20000615 - BIOVATION LTD [GB], et al
US 90337801 A 20010710
US 3917002 A 20020104
US 22269700 P 20000802
WO 0121823 A2 20010329 - MATHILDA & TERENCE KENNEDY INS [GB], et al
WO 0200165 A2 20020103 - BAKULESH MAFATLAL KHAMAR [IN]
WO 9859244 A1 19981230 - ECLAGEN LTD [GB], et al
WO 02069232 A2 20020906 - MERCK PATENT GMBH [DE], et al
WO 02077187 A2 20021003 - GENENCOR INT [US], et al
US 82223104 A 20040326
US 8037602 A 20020219
US 79263001 A 20010222
US 2320801 A 20011214
US 8267102 A 20020222
US 95335101 A 20010914
US 9710002 A 20020312
US 36665806 P
WO 0022906 A2 20000427 - WCL WIRELESS COMMERCE LTD OY [FI], et al
WO 0149058 A1 20010705 - MITSUBISHI ELECTRIC CORP [JP], et al
WO 0204852 A1 20020117 - ASCO JOUCOMATIC [FR], et al
WO 0204853 A1 20020117 - SUGIMOTO MOTOICHI [JP]
WO 0208023 A2 20020131 - TRW INC [US]
WO 0128702 A1 20010426 - MINERGY CORP [US], et al
WO 0207466 A1 20020124 - SIEMENS AG [DE], et al
WO 0042561 A2 20000720 - MAXYGEN INC [US], et al
WO 0170947 A2 20010927 - MAXYGEN INC [US], et al
US 6365377 B1 20020402 - PATTEN PHILLIP A [US], et al
US 6376246 B1 20020423 - CRAMERI ANDREAS [CH], et al
WO 0206469 A2 20020124 - ENCHIRA BIOTECHNOLOGY CORP [US], et al
US 6352842 B1 20020305 - SHORT JAY M [US]
US 6361974 B1 20020326 - SHORT JAY M [US], et al
US 6358709 B1 20020319 - SHORT JAY M [US], et al
US 5824514 A 19981020 - KAUFFMAN STUART ALAN [US], et al
US 5817483 A 19981006 - KAUFFMAN STUART ALAN [US], et al
US 5814476 A 19980929 - KAUFFMAN STUART ALAN [US], et al
US 5763192 A 19980609 - KAUFFMAN STUART ALAN [US], et al
US 5723323 A 19980303 - KAUFFMAN STUART ALAN [US], et al
US 52822903 P 20031208
US 61494404 P 20040929
US 61940904 P 20041014
US 62138704 P 20041021
US 62906804 P 20041118
US 37074903 A 20030220
US 4943533 A 19900724 - MENDELSOHN JOHN [US], et al
WO 9640210 A1 19961219 - IMCLONE SYSTEMS INC [US], et al
WO 9520045 A1 19950727 - CANCER RES INST ROYAL [GB], et al
RITTER ET AL., CANCER RESEARCH, vol. 61, 2001, pages 6851 - 6859
CLARK, IMMUNOLOGY TODAY, vol. 21, 2000, pages 397 - 402
MACCALLUM ET AL., J. MOL. BIOL., vol. 262, 1996, pages 732 - 745
CHOTHIA; LESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 877 - 883
AI-LAZIKANI ET AL., J. MOL. BLOL, vol. 273, 1997, pages 927 - 948
BRUGGEMANN ET AL., CURR OPIN BIOTECHNOL, vol. 8, 1997, pages 455 - 458
GRIFFITHS ET AL., CURR OPIN BIOTECHNOL, vol. 9, 1998, pages 102 - 108
CLARK, LMMUNOL TODAY, vol. 21, 2000, pages 397 - 402
IDUSOGIE ET AL., J. IMMUNOLOGY, vol. 166, 2001, pages 2571 - 2572
HINTON ET AL., J. BIOL. CHEM., vol. 279, no. 8, 2004, pages 6213 - 6216
UMANA ET AL., NAT BLOTECHNOL, vol. 17, 1999, pages 176 - 180
DAVIES ET AL., BIOTECHNOL BIOENG, vol. 74, 2001, pages 288 - 294
SHIELDS ET AL., J BIOL CHEM, vol. 277, 2002, pages 26733 - 26740
SHINKAWA ET AL., J BIOL CHEM, vol. 278, 2003, pages 3466 - 3473
JOHNSON; WU, NUCLEIC ACIDS RES, vol. 29, 2001, pages 205 - 206
JOHNSON; WU, NUCLEIC ACIDS RES, vol. 28, 2000, pages 214 - 218
LEFRANC ET AL., NUCLEIC ACIDS RES, vol. 27, 1999, pages 209 - 212
RUIZ ET AL., NUCLEIC ACIDS RE., vol. 28, 2000, pages 219 - 221
LEFRANC ET AL., NUCLEIC ACIDS RES, vol. 29, 2001, pages 207 - 209
LEFRANC ET AL., NUCLEIC ACIDS RES, vol. 31, 2003, pages 307 - 310
AI-LAZIKANI ET AL., J. MOL. BIOL., vol. 273, 1997, pages 927 - 948
MATSUDA ET AL., J EXP MED, vol. 188, 1998, pages 2151 - 2162
ZACHAU, BIOL CHEM, vol. 381, 2000, pages 951 - 954
PALLARES ET AL., EXP CLIN IMMUNOGENET, vol. 16, no. 1, 1999, pages 36 - 60
BARBIE; LEFRANC, EXP CLIN IMMUNOGENET, vol. 15, no. 3, 1998, pages 171 - 83
COX ET AL., EUR J LMMUNOL., vol. 24, no. 4, April 1994 (1994-04-01), pages 827 - 36
LEHMANN; WYSS, CURROPIN BIOTECHNO, vol. 12, no. 4, 2001, pages 371 - 5
LEHMANN ET AL., BIOCHIM BIOPHYS ACTA, vol. 1543, no. 2, 2000, pages 408 - 415
RATH; DAVIDSON, PROTEIN SCI, vol. 9, no. 12, 2000, pages 2457 - 69
LEHMANN, PROTEIN ENG, vol. 13, no. 1, 2000, pages 49 - 57
DESJARLAIS; BERG, PROC NATL ACAD SCI USA, vol. 90, no. 6, 1993, pages 2256 - 60
DESJARLAIS; BERG, PROTEINS, vol. 12, no. 2, 1992, pages 101 - 4
HENIKOFF; HENIKOFF, ADV PROTEIN CHEM, vol. 54, 2000, pages 73 - 97
HENIKOFF; HENIKOFF, J MOL BIOL, vol. 243, no. 4, 1994, pages 574 - 8
ARNOLD ET AL., J IMMUNOLOGY, vol. 169, no. 2, 2002, pages 739 - 49
RAHA ET AL., PROTEIN SCI, vol. 9, 2000, pages 1106 - 1119
BOWIE, SCIENCE, vol. 247, 1990, pages 1306 - 1310
BOWIE; SAUER, PROC. NAT. ACAD. SCI. USA, vol. 86, 1989, pages 2152 - 2156
REIDHAAR-OLSON; SAUER, PROTEINS, vol. 7, 1990, pages 306 - 316
LIM ET AL., BIOCHEM., vol. 31, 1992, pages 4324 - 4333
TOPHAM ET AL., PROTO ENG., vol. 10, 1997, pages 7 - 21
ADENOT ET AL., J. MOL. GRAPH. MODEL., vol. 17, 1999, pages 292 - 309
HENIKOFF; HENIKOFF, PROC. NAT. ACAD. SCI. USA, vol. 89, 1992, pages 10917
HENIKOFF, CURR. OPIN. STRUCT. BIOL., vol. 6, 1996, pages 353 - 360
HENIKOFF; HENIKOFF, COMPUT. APPL. BIOSCI., vol. 12, 1996, pages 135 - 143
MALLIOS, BIOINFORMATICS, vol. 15, 1999, pages 432 - 439
MALLIOS, BIOINFORMATICS, vol. 17, 2001, pages 942 - 948
STUMIOLO ET AL., NATURE BIOTECH, vol. 17, 1999, pages 555 - 561
MARSHALL ET AL., J. IMMUNOL., vol. 154, 1995, pages 5927 - 5933
HAMMER ET AL., J. EXP. MED., vol. 180, 1994, pages 2353 - 2358
STUMIOLO, NATURE BIOTECH, vol. 17, 1999, pages 555 - 561
MARSHALL, J. IMMUNOL., vol. 154, 1995, pages 5927 - 5933
CLARK, IMMUNOL TODAY, vol. 21, 2000, pages 397 - 402
GRIFFITHS ET AL., CURR OPIN BIOTECHNOL, vol. 9, 1998, pages 102.108
HAYHURST; GEORGIOU, CURR OPIN CHEM BIOL, vol. 5, 2001, pages 683 - 689
MAYNARD; GEORGIOU, ANNU REV BIOMED ENG, vol. 2, 2000, pages 339 - 76
WITRRUP, CURR OPIN , BIOTECHNOL, vol. 12, 2001, pages 395 - 399
LOWMAN ET AL., BIOCHEMISTRY, vol. 30, 1991, pages 10832 - 10838
SMITH, SCIENCE, vol. 228, 1985, pages 1315 - 1317
MALMBORG ET AL., J MOL BIOL, vol. 273, 1997, pages 544 - 551
KREBBER ET AL., J MOL BIOL, vol. 268, 1997, pages 619 - 630
BENHAR ET AL., J MOL BIOL, vol. 301, 2000, pages 893 - 904
WITRRUP, CURR OPIN BIOTECHNOL, vol. 12, 2001, pages 395 - 399
GEORGIOU ET AL., NAT BIOTECHNOL, vol. 15, 1997, pages 29 - 34
GEORGIOU ET AL., TRENDS BIOTECHNOL, vol. 11, 1993, pages 6 - 10
LEE ET AL., NAT BIOTECHNOL, vol. 18, 2000, pages 645 - 648
JUN ET AL., NAT BIOTECHNOL, vol. 16, 1998, pages 576 - 80
BODER; WITTRUP, METHODS ENZYMOL, vol. 328, 2000, pages 430 - 44
BODER; WITTRUP, NAT BIOTECHNOL, vol. 15, 1997, pages 553 - 557
WHITEHOM ET AL., BIOLTECHNOLOGY, vol. 13, 1995, pages 1215 - 1219
AMSTUTZ ET AL., CURR OPIN BIOTECHNOL, vol. 12, 2001, pages 400 - 405
MATTHEAKIS ET AL., PROC NATL ACAD SCI USA, vol. 91, 1994, pages 9022 - 9026
HANES ET AL., PROC NATL ACAD SCI USA, vol. 94, 1997, pages 4937 - 4942
ROBERTS; SZOSTAK, PROC NATL ACAD SCI USA, vol. 94, 1997, pages 12297 - 12302
NEMOTO ET AL., FEBS LETT, vol. 414, 1997, pages 405 - 408
ZHOU ET AL., J AM CHEM SOC, vol. 124, 2002, pages 538 - 543
CHEN ET AL., NAT BIOTECHNOL, vol. 19, 2001, pages 537 - 542
JOHNSSON; VARSHAVSKY, PROC NATL ACAD SCI USA, vol. 91, 1994, pages 10340 - 10344
PELLETIER ET AL., PROC NATL ACAD SCI USA, vol. 95, pages 12141 - 12146
FIELDS; SONG, NATURE, vol. 340, 1989, pages 245 - 246
VISINTIN, PROC NATL ACAD SCI USA, vol. 96, 1999, pages 11723 - 11728
KOLKMAN; STEMMER, NAT BIOTECHNOL, vol. 19, 2001, pages 423 - 428
CRAMERI ET AL., NATURE, vol. 391, 1998, pages 288 - 291
COCO ET AL., NAT BIOTECHNOL, vol. 19, 2001, pages 354 - 359
ZHAO ET AL., NAT BIOTECHNOL, vol. 16, 1998, pages 258 - 261
SHAO ET AL., NUCLEIC ACIDS RES, vol. 26, 1998, pages 681 - 683
LUTZ ET AL., PROC NATL ACAD SCI USA, vol. 98, 2001, pages 11248 - 11253
KIKUCHI ET AL., GENE, vol. 236, pages 159 - 167
KIKUCHI ET AL., GENE, vol. 243, 2000, pages 133 - 137
SCHMITTEL, J. IMMUNOL. MEFH., vol. 24, 2000, pages 17 - 24
MEIDENBAUER ET AL., PROSTATE, vol. 43, 2000, pages 88 - 100
SCHULTES; WHITESIDE, J. LMMUNOL. METHODS, vol. 279, 2003, pages 1 - 15
STICKLER ET AL., 200, J. IMMUNOTHERAPY, vol. 23, pages 654 - 660
SONDERSTRUP ET AL., IMMUNOL. REV, vol. 172, 1999, pages 335 - 343
FORSTHUBER ET AL., J. IMMUNOL., vol. 167, 2001, pages 119 - 125
BOWEN ET AL., JOUMAL OF IMMUNOLOGY, vol. 151, 1993, pages 5896
MICHAELSEN ET AL., MOLECULAR IMMUNOLOGY, vol. 29, no. 3, 1992, pages 319 - 326
CANFIELD; MORRISON, J. EXP. MED., vol. 173, 1991, pages 1483 - 1491
CHAPPEL ET AL., PROC. NATL. ACAD. SCI. USA, vol. 88, no. 20, 1991, pages 9036 - 9040
CHAPPEL ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, 1993, pages 25124 - 25131
TAO ET AL., J . EXP. MED., vol. 173, 1991, pages 1025 - 1028
TAO ET AL., J. EXP. MED., vol. 178, 1993, pages 661 - 667
REDPATH ET AL., HUMAN IMMUNOLOGY, vol. 59, 1998, pages 720 - 727
SKERRA, GENE, vol. 141, 1994, pages 79 - 84
MODJTAHEDI ET AL., J. CELL BIOPHYS., vol. 22, no. 1-3, 1993, pages 129 - 46
MODJTAHEDI ET AL., BRJ CANCER, vol. 67, no. 2, 1993, pages 247 - 53
MODJTAHEDI ET AL., BR J CANCER, vol. 73, no. 2, 1996, pages 228 - 35
MODJTAHEDI ET AL., INT J CANCER, vol. 105, no. 2, 2003, pages 273 - 80

Citation (search report)

[A] WO 03043583 A2 20030530 - SEATTLE GENETICS INC [US], et al
[L] EP 1951757 A2 20080806 - XENCOR INC [US]
[T] LAZAR ET AL: "A molecular immunology approach to antibody humanization and functional optimization", MOLECULAR IMMUNOLOGY, PERGAMON, GB LNKD- DOI:10.1016/J.MOLIMM.2006.09.029, vol. 44, no. 8, 1 December 2006 (2006-12-01), pages 1986 - 1998, XP005792736, ISSN: 0161-5890

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

WO 2005056759 A2 20050623; WO 2005056759 A3 20050915; AU 2004297616 A1 20050623; AU 2004297616 B2 20081218; CA 2548817 A1 20050623; EP 1697741 A2 20060906; EP 1697741 A4 20080213; EP 2221315 A1 20100825; JP 2007512846 A 20070524; US 2006008883 A1 20060112; US 2008167449 A1 20080710; US 2010190247 A1 20100729; US 2011236969 A1 20110929; US 7657380 B2 20100202; US 7930107 B2 20110419

DOCDB simple family (application)

US 2004040694 W 20041203; AU 2004297616 A 20041203; CA 2548817 A 20041203; EP 04813075 A 20041203; EP 10004410 A 20041203; JP 2006542831 A 20041203; US 201113053087 A 20110321; US 459004 A 20041203; US 72294810 A 20100312; US 98179407 A 20071031