EP 2222638 A2 20100901 - BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION
Title (en)
BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION
Title (de)
BIARYLE ALS PDE4-INHIBITOREN ZUR BEHANDLUNG VON ENTZÜNDUNGEN
Title (fr)
INHIBITEURS DE PDE4 BIARYLE POUR TRAITER UNE INFLAMMATION
Publication
Application
Priority
- US 2008084193 W 20081120
- US 98955107 P 20071121
Abstract (en)
[origin: WO2009067600A2] The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula I: (formula should be inserted here). A particular embodiment is (a second formula should be inserted here)
IPC 8 full level
C07D 213/76 (2006.01); C07C 275/32 (2006.01); C07C 275/62 (2006.01); C07C 305/24 (2006.01); C07C 307/10 (2006.01); C07D 213/81 (2006.01); C07D 213/89 (2006.01); C07D 257/04 (2006.01); C07D 275/06 (2006.01); C07D 285/12 (2006.01); C07D 403/04 (2006.01)
CPC (source: EP)
A61P 7/12 (2017.12); A61P 9/00 (2017.12); A61P 9/10 (2017.12); A61P 11/06 (2017.12); A61P 11/08 (2017.12); A61P 13/06 (2017.12); A61P 13/10 (2017.12); A61P 19/02 (2017.12); A61P 19/10 (2017.12); A61P 25/00 (2017.12); A61P 25/14 (2017.12); A61P 25/18 (2017.12); A61P 25/28 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07C 275/32 (2013.01); C07C 275/62 (2013.01); C07C 305/24 (2013.01); C07C 307/10 (2013.01); C07D 207/16 (2013.01); C07D 213/38 (2013.01); C07D 213/40 (2013.01); C07D 213/64 (2013.01); C07D 213/74 (2013.01); C07D 213/75 (2013.01); C07D 213/76 (2013.01); C07D 213/79 (2013.01); C07D 213/81 (2013.01); C07D 213/84 (2013.01); C07D 213/89 (2013.01); C07D 231/12 (2013.01); C07D 233/90 (2013.01); C07D 239/42 (2013.01); C07D 257/04 (2013.01); C07D 275/06 (2013.01); C07D 285/12 (2013.01); C07D 285/135 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 403/04 (2013.01); C07D 471/04 (2013.01); C07D 473/18 (2013.01); C07D 473/40 (2013.01); C07B 2200/05 (2013.01)
Citation (search report)
See references of WO 2009067600A2
Citation (examination)
- US 5877190 A 19990302 - DHAINAUT ALAIN [FR], et al
- EP 0249963 A2 19871223 - IDEMITSU KOSAN CO [JP]
- DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SMIRNOV, L. D. ET AL: "Synthesis and study of some electrophilic reactions of 2-phenyl-3-hydroxypyridine N-oxides", retrieved from STN Database accession no. 1973:442297 & IZVESTIYA AKADEMII NAUK SSSR, SERIYA KHIMICHESKAYA , (4), 861-4 CODEN: IASKA6; ISSN: 0002-3353, 1973
- DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SMIRNOV, L. D. ET AL: "Chemistry of 2-aryl substituted 3-hydroxypyridines. 1. Aminomethylation of 2-phenyl- and 2-(4'-alkylphenyl)-3-hydroxypyridines", retrieved from STN Database accession no. 1971:76279 & IZVESTIYA AKADEMII NAUK SSSR, SERIYA KHIMICHESKAYA , (8), 1845-51 CODEN: IASKA6; ISSN: 0002-3353, 1970
- DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; LIVERMORE, R. A. ET AL: "Reactions in the diethyl peroxide-nitric oxide system. III. The pressure dependence of the combination of ethoxyl radicals with nitric oxide", retrieved from STN Database accession no. 1966:446901 & JOURNAL OF THE CHEMICAL SOCIETY [SECTION] B: PHYSICAL ORGANIC , (7), 640-3 CODEN: JCSPAC; ISSN: 0045-6470, 1966
- DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ALAMI, MOUAD ET AL: "Preparation of dihydro-iso-CA-4 and analogues as potent cytotoxic compounds and inhibitors of tubulin polymerization", retrieved from STN Database accession no. 2009:1536640 & WO 2009147217 A1 20091210 - CENTRE NAT RECH SCIENT [FR], et al
- DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CHEN, YONGSHENG ET AL: "Preparation of pyrimidines as adenosine A2A receptor antagonists", retrieved from STN Database accession no. 2008:1157507 & WO 2008116185 A2 20080925 - NEUROCRINE BIOSCIENCES INC [US], et al
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA MK RS
DOCDB simple family (publication)
WO 2009067600 A2 20090528; WO 2009067600 A3 20090730; AU 2008326381 A1 20090528; AU 2008326381 B2 20141023; CA 2722582 A1 20090528; CN 102089279 A 20110608; EP 2222638 A2 20100901; JP 2011505341 A 20110224
DOCDB simple family (application)
US 2008084193 W 20081120; AU 2008326381 A 20081120; CA 2722582 A 20081120; CN 200880125175 A 20081120; EP 08851045 A 20081120; JP 2010535064 A 20081120