EP 2223935 A2 20100901 - Compounds and methods for treatment and diagnosis of chlamydial infection

Title (en)

Compounds and methods for treatment and diagnosis of chlamydial infection

Title (de)

Verbindungen und Verfahren zur Behandlung und Diagnose von Chlamydia-Infektionen

Title (fr)

Composés et procédés pour le traitement et le diagnostic des infections à chlamydia

Publication

EP 2223935 A2 20100901 (EN)

Application

EP 10163839 A 19991208

Priority

EP 99963037 A 19991208
US 20827798 A 19981208
US 28859499 A 19990408
US 41056899 A 19991001
US 42657199 A 19991022

Abstract (en)

Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

IPC 8 full level

C07K 14/295 (2006.01); G01N 33/53 (2006.01); A61K 35/12 (2006.01); A61K 38/00 (2006.01); A61K 39/118 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 33/00 (2006.01); C07K 16/12 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/31 (2006.01); C12N 15/62 (2006.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); G01N 33/532 (2006.01); G01N 33/569 (2006.01); A61K 39/00 (2006.01); C12R 1/01 (2006.01)

CPC (source: EP KR)

A61P 31/00 (2018.01 - EP); A61P 33/00 (2018.01 - EP); C07K 14/295 (2013.01 - EP KR); A61K 39/00 (2013.01 - EP KR); A61K 2039/51 (2013.01 - EP); C07K 2319/00 (2013.01 - EP)

Citation (applicant)

WO 9638591 A1 19961205 - INCYTE PHARMA INC [US]
US 10358498 A 19980624
US 4935233 A 19900619 - BELL LESLIE D [GB], et al
US 4751180 A 19880614 - COUSENS LAWRENCE S [US], et al
WO 9118926 A1 19911212 - FORSGREN ARNE [SE]
US 4918164 A 19900417 - HELLSTROM INGEGERD [US], et al
US 4235877 A 19801125 - FULLERTON WILLIAM W [US]
US 4603112 A 19860729 - PAOLETTI ENZO [US], et al
US 4769330 A 19880906 - PAOLETTI ENZO [US], et al
US 5017487 A 19910521 - STUNNENBERG HENDRIK G [DE], et al
WO 8901973 A2 19890309 - APPLIED BIOTECHNOLOGY INC [US], et al
US 4777127 A 19881011 - SUNI JUKKA [FI], et al
GB 2200651 A 19880810 - AL SUMIDAIE AYAD MOHAMED KHALA
EP 0345242 A2 19891206 - SMITHKLINE BIOLOG [BE]
WO 9102805 A2 19910307 - VIAGENE INC [US]
US 4897268 A 19900130 - TICE THOMAS R [US], et al
US 5075109 A 19911224 - TICE THOMAS R [US], et al
US 4436727 A 19840313 - RIBI EDGAR E [US]
US 4877611 A 19891031 - CANTRELL JOHN L [US]
US 4866034 A 19890912 - RIBI EDGAR E [US]
US 4912094 A 19900327 - MYERS KENT R [US], et al
WO 9602555 A1 19960201 - UNIV IOWA RES FOUND [US]
WO 9400153 A1 19940106 - SMITHKLINE BEECHAM BIOLOG [BE], et al
WO 9633739 A1 19961031 - SMITHKLINE BEECHAM BIOLOG [BE], et al
WO 9517210 A1 19950629 - SMITHKLINE BEECHAM BIOLOG [BE], et al
WO 9724447 A1 19970710 - VIAGENE INC [US]
US 5359681 A 19941025 - JORGENSON RALPH C [US], et al
US 4671958 A 19870609 - RODWELL JOHN D [US], et al
US 4489710 A 19841225 - SPITLER LYNN E [US]
US 4625014 A 19861125 - SENTER PETER D [US], et al
US 4638045 A 19870120 - KOHN JOACHIM [US], et al
US 4569789 A 19860211 - BLATTLER WALTER A [US], et al
US 4507234 A 19850326 - KATO YOSHINORI [JP], et al
US 4699784 A 19871013 - SHIH LISA B [US], et al
US 4429008 A 19840131 - MARTIN FRANK J [US], et al
US 4873088 A 19891010 - MAYHEW ERIC [US], et al
US 4735792 A 19880405 - SRIVASTAVA PREM C [US]
US 4673562 A 19870616 - DAVISON ALAN [US], et al
ADELMAN ET AL., DNA, vol. 2, 1983, pages 183
HIGGINS, D.G.; SHARP, P.M.: "Fast and sensitive multiple sequence alignments on a microcomputer", CABIOS, vol. 5, 1989, pages 151 - 153
MYERS, E.W.; MULLER W.: "Optimal alignments in linear space", CABIOS, vol. 4, 1988, pages 11 - 17
ROBINSON, E.D., COMB. THEOR, vol. 11, 1971, pages 105
SANTOU, N.; NES, M.: "The neighbor joining method. A new method for reconstructing phylogenetic trees", MOL. BIOL. EVOL., vol. 4, 1987, pages 406 - 425
WILBUR, W.J.; LIPMAN, D.J.: "Rapid similarity searches of nucleic acid and protein data banks", PROC. NATL. ACAD., SCI. USA, vol. 80, 1983, pages 726 - 730
SCHENA ET AL., PROC. NATL. ACAD. SCI., vol. 93, 1996, pages 10614 - 10619
HELLER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 94, 1997, pages 2150 - 2155
EDMAN; BERG, EUR. J BIOCHEM., vol. 80, 1967, pages 116 - 132
MULLIS ET AL., COLD SPRING HARBOR SYMP. QUANT. BIOL., vol. 51, 1987, pages 263
TRIGLIA ET AL., NUCL. ACIDS RES., vol. 16, 1988, pages 8186
LAGERSTROM ET AL., PCR METHODS APPLIC., vol. 1, 1991, pages 111 - 19
PARKER ET AL., NUCL. ACIDS. RES., vol. 19, 1991, pages 3055 - 60
MERRIFIELD, J. AM. CHEM. SOC., vol. 85, 1963, pages 2149 - 2146
MARATEA ET AL., GENE, vol. 40, 1985, pages 39 - 46
MURPHY ET AL., PROC. NATL. ACAD SCI. USA, vol. 83, 1986, pages 8258 - 8562
STOUTE ET AL., NEW ENGL. J. MED., vol. 336, 1997, pages 86 - 91
GENE, vol. 43, 1986, pages 265 - 292
BIOTECHNOLOGY, vol. 10, 1992, pages 795 - 798
ULMER ET AL., SCIENCE, vol. 259, 1993, pages 1745 - 1749
COHEN, SCIENCE, vol. 259, 1993, pages 1691 - 1692
CHEEVER, M.: "Therapy With Cultured T Cells: Principles Revisited", IMMUNOLOGICAL REVIEWS, vol. 157, 1997, pages 177
CHANG ET AL., CRIT. REV. ONCOL. HEMATOL., vol. 22, no. 3, 1996, pages 213
ESHHAR, Z., CANCER IMMUNOL IMMUNOTHER, vol. 45, no. 3-4, 1997, pages 131 - 6
HWU. P. ET AL., CANCER RES, vol. 55, no. 15, 1995, pages 3369 - 73
COLE, DJ ET AL., CANCER RES, vol. 55, no. 4, 1995, pages 748 - 52
CHEEVER ET AL., IMMUNOLOGICAL REVIEWS, vol. 157, 1997, pages 177
ROLLAND, CRIT. REV. THERAP. DRUG CARRIER SYSTEMS, vol. 15, 1998, pages 143 - 198
FISHER-HOCH ET AL., PROC. NATL. ACAD. SCI. USA, vol. 86, 1989, pages 317 - 321
FLEXNER ET AL., ANN. N.Y ACAD. SCI., vol. 569, 1989, pages 86 - 103
FLEXNER ET AL., VACCINE, vol. 8, 1990, pages 17 - 21
BERKNER, BIOTECHNIQUES, vol. 6, 1988, pages 616 - 627
ROSENFELD ET AL., SCIENCE, vol. 252, 1991, pages 431 - 434
KOLLS ET AL., PROC. NATL. ACAD. SCI. USA, vol. 91, 1994, pages 215 - 219
KASS-EISLER ET AL., PROC. NATL. ACAD SCI. USA, vol. 90, 1993, pages 11498 - 11502
GUZMAN ET AL., CIRCULATION, vol. 88, 1993, pages 2838 - 2848
GUZMAN ET AL., CIR. RES., vol. 73, 1993, pages 1202 - 1207
MOSMANN; COFFMAN, ANN. REV. IMMUNOL., vol. 7, 1989, pages 145 - 173
BANCHEREAU; STEINMAN, NATURE, vol. 392, 1998, pages 245 - 251
TIMMERMAN; LEVY, ANN. REV. MED., vol. 50, 1999, pages 507 - 529
ZITVOGEL ET AL., NATURE MED., vol. 4, 1998, pages 594 - 600
MAHVI ET AL., IMMUNOLOGY AND CELL BIOLOGY, vol. 75, 1997, pages 456 - 460
KOHLER; MILSTEIN, EUR. J IMMUNOL., vol. 6, 1976, pages 511 - 519
SANDERSON ET AL., J. EXP. MED., vol. 182, 1995, pages 1751 - 1757
GU, L. ET AL., J. BACTERIOLOGY, vol. 177, 1995, pages 2594 - 2601
WEBB ET AL., J. IMMUNOLOGY, vol. 157, 1996, pages 5034 - 5041
STARNBACH, M., J. IMMUNOL., vol. 153, 1994, pages 5183
LALVANI ET AL., J EXPERIMENTAL MEDICINE, vol. 186, 1997, pages 859 - 865
DENAMUR, E.; C. SAYADA; A. SOURIAU; J. ORFILA; A. RODOLAKIS; J. ELION., J. GEN. MICROBIOL., vol. 137, 1991, pages 2525
SCUDIERO ET AL., CANCER RESEARCH, vol. 48, 1988, pages 4827
WEBB ET AL., J IMMUNOLOGY, vol. 157, 1996, pages 5034 - 5041

Citation (examination)

WO 0140474 A2 20010607 - CORIXA CORP [US], et al
DATABASE GENESEQ [online] 5 September 2001 (2001-09-05), "Chlamydia trachomatis DNA clone CtL2gam-17.", retrieved from EBI accession no. GSN:AAH56308 Database accession no. AAH56308
PARANHOS G S ET AL: "Trypanosoma cruzi: Cloning and expression of an antigen recognized by acute and chronic human chagasic sera", EXPERIMENTAL PARASITOLOGY, NEW YORK, NY, US, vol. 71, no. 3, 1 October 1990 (1990-10-01), pages 284 - 293, XP026247400, ISSN: 0014-4894, [retrieved on 19901001], DOI: 10.1016/0014-4894(90)90033-9

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0034483 A2 20000615; WO 0034483 A3 20011101; WO 0034483 A9 20010705; AT E469222 T1 20100615; AU 1935800 A 20000626; AU 2004201702 A1 20040520; AU 2004201702 B2 20070705; AU 769293 B2 20040122; BR 9916020 A 20020122; CA 2354232 A1 20000615; CA 2746535 A1 20000615; CN 100365120 C 20080130; CN 1333832 A 20020130; DE 69942426 D1 20100708; EP 1144642 A2 20011017; EP 1144642 B1 20100526; EP 2218733 A1 20100818; EP 2223935 A2 20100901; EP 2223935 A3 20101124; EP 2277892 A2 20110126; EP 2277892 A3 20110427; EP 2277893 A2 20110126; EP 2277893 A3 20110330; ES 2346832 T3 20101020; HK 1044020 A1 20021004; HK 1044020 B 20081031; HU P0400719 A2 20040728; HU P0400719 A3 20100830; IL 143531 A0 20020421; IL 209113 A0 20110131; IL 209114 A0 20110131; IL 209115 A0 20110131; IL 209116 A0 20110131; JP 2002531129 A 20020924; JP 2011036258 A 20110224; KR 100829407 B1 20080515; KR 20010101152 A 20011114; KR 20070108263 A 20071108; KR 20090088972 A 20090820; KR 20100132086 A 20101216; MX PA01005813 A 20020506; NO 20012812 D0 20010607; NO 20012812 L 20010802; NO 20101293 L 20010802; NZ 512246 A 20031219; PL 363147 A1 20041115; TR 200102500 T2 20020321

DOCDB simple family (application)

US 9929012 W 19991208; AT 99963037 T 19991208; AU 1935800 A 19991208; AU 2004201702 A 20040422; BR 9916020 A 19991208; CA 2354232 A 19991208; CA 2746535 A 19991208; CN 99815723 A 19991208; DE 69942426 T 19991208; EP 10163838 A 19991208; EP 10163839 A 19991208; EP 10179022 A 19991208; EP 10179569 A 19991208; EP 99963037 A 19991208; ES 99963037 T 19991208; HK 02105516 A 20020726; HU P0400719 A 19991208; IL 14353199 A 19991208; IL 20911310 A 20101104; IL 20911410 A 20101104; IL 20911510 A 20101104; IL 20911610 A 20101104; JP 2000586916 A 19991208; JP 2010209037 A 20100917; KR 20017007165 A 20010608; KR 20077022107 A 20070927; KR 20097016159 A 19991208; KR 20107027275 A 19991208; MX PA01005813 A 19991208; NO 20012812 A 20010607; NO 20101293 A 20100914; NZ 51224699 A 19991208; PL 36314799 A 19991208; TR 200102500 T 19991208