EP 2225207 A2 20100908 - TETRAHYDRO-ISOQUINOLINE PPAT INHIBITORS AS ANTIBACTERIAL AGENTS
Title (en)
TETRAHYDRO-ISOQUINOLINE PPAT INHIBITORS AS ANTIBACTERIAL AGENTS
Title (de)
TETRAHYDROISOCHINOLINE ALS PPAT-INHIBITOREN ZUR VERWENDUNG ALS ANTIBAKTERIELLE MITTEL
Title (fr)
INHIBITEURS TÉTRAHYDRO-ISOQUINOLINO DE PPAT UTILISÉS EN TANT QU'AGENTS ANTIBACTÉRIENS
Publication
Application
Priority
- US 2008084948 W 20081126
- US 99152507 P 20071130
Abstract (en)
[origin: WO2009073545A2] Disclosed are Tetrahydro-isoquinoline derivatives such as structural formula (I), pharmaceutical compositions comprising them and methods of treating bacterial infections. The disclosed compounds are inhibitors of PPAT (phosphopantetheine adenyl transferase), and are useful in the treatment and prevention of diseases caused by bacteria, particularly bacteria dependent on PPAT, for example, species such Escherichia coli, Helicobacter pylori, Staphyloccocus aureus, and the like. Description of the variables in structural formula (I) are provided herein.
IPC 8 full level
C07D 217/12 (2006.01); C07D 217/14 (2006.01)
CPC (source: EP)
A61P 31/04 (2017.12); C07D 217/14 (2013.01); C07D 401/10 (2013.01); C07D 491/056 (2013.01)
Citation (search report)
See references of WO 2009073545A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA MK RS
DOCDB simple family (publication)
WO 2009073545 A2 20090611; WO 2009073545 A3 20090911; AU 2008334075 A1 20090611; CA 2707445 A1 20090611; CN 102007101 A 20110406; EP 2225207 A2 20100908; JP 2011518109 A 20110623
DOCDB simple family (application)
US 2008084948 W 20081126; AU 2008334075 A 20081126; CA 2707445 A 20081126; CN 200880126018 A 20081126; EP 08857446 A 20081126; JP 2010536184 A 20081126