EP 2231673 A1 20100929 - METHOD FOR THE PREPARATION OF MORPHINE COMPOUNDS
Title (en)
METHOD FOR THE PREPARATION OF MORPHINE COMPOUNDS
Title (de)
HERSTELLUNGSVERFAHREN VON MORPHIUMVERBINDUNGEN
Title (fr)
PROCEDE DE PREPARATION DE COMPOSES MORPHINIQUES
Publication
Application
Priority
- FR 2008001558 W 20081106
- FR 0758923 A 20071109
- US 2194908 P 20080118
Abstract (en)
[origin: FR2923484A1] Preparation of morphine compounds with low content of ~a-~b unsaturated compounds, comprises: contacting crude morphine compound with a base in conditions allowing Michael addition reaction on the ~a-~b unsaturated compounds; separating morphine compound of the reaction mixture; and optionally separating the addition product formed from the morphine compound. An independent claim is included for a composition comprising at least 99% in dry weight of morphine compound or its salt and ~a-~b unsaturated compound having a content of less than 100 ppm. ACTIVITY : Analgesic. MECHANISM OF ACTION : None given.
IPC 8 full level
C07D 489/00 (2006.01); A61K 31/485 (2006.01); A61P 29/00 (2006.01); C07B 63/02 (2006.01); C07D 489/08 (2006.01)
CPC (source: EP US)
A61P 29/00 (2017.12 - EP); C07B 63/02 (2013.01 - EP US); C07D 489/00 (2013.01 - EP US); C07D 489/08 (2013.01 - EP US)
Citation (search report)
See references of WO 2009092912A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA MK RS
DOCDB simple family (publication)
FR 2923484 A1 20090515; FR 2923484 B1 20121109; AR 069225 A1 20100106; AU 2008348675 A1 20090730; BR PI0820300 A2 20150519; CA 2705251 A1 20090730; CL 2008003333 A1 20100305; CN 101868462 A 20101020; EA 017287 B1 20121130; EA 201070589 A1 20101029; EP 2231673 A1 20100929; IL 205601 A0 20101130; JP 2011503040 A 20110127; KR 20100083815 A 20100722; MA 31982 B1 20110103; MX 2010005124 A 20100527; NZ 585218 A 20120831; SG 186591 A1 20130130; TW 200936592 A 20090901; US 2010256176 A1 20101007; US 8455509 B2 20130604; UY 31460 A1 20090717; WO 2009092912 A1 20090730; ZA 201003241 B 20110831
DOCDB simple family (application)
FR 0758923 A 20071109; AR P080104878 A 20081107; AU 2008348675 A 20081106; BR PI0820300 A 20081106; CA 2705251 A 20081106; CL 2008003333 A 20081107; CN 200880115278 A 20081106; EA 201070589 A 20081106; EP 08871482 A 20081106; FR 2008001558 W 20081106; IL 20560110 A 20100506; JP 2010532634 A 20081106; KR 20107010076 A 20081106; MA 32893 A 20100607; MX 2010005124 A 20081106; NZ 58521808 A 20081106; SG 2012079125 A 20081106; TW 97143241 A 20081107; US 77415610 A 20100505; UY 31460 A 20081107; ZA 201003241 A 20100507