EP 2234630 A4 20120808 - METHOD OF STIMULATING THE MOTILITY OF THE GASTROINTESTINAL SYSTEM USING IPAMORELIN
Title (en)
METHOD OF STIMULATING THE MOTILITY OF THE GASTROINTESTINAL SYSTEM USING IPAMORELIN
Title (de)
VERFAHREN ZUR STIMULIERUNG DER MOTILITÄT DES GASTROINTESTINAL-SYSTEMS MIT IPAMORELIN
Title (fr)
MÉTHODE DE STIMULATION DE LA MOTILITÉ DU SYSTÈME GASTRO-INTESTINAL À L'AIDE D'IPAMORÉLINE
Publication
Application
Priority
- US 2008013156 W 20081126
- US 882807 P 20071221
Abstract (en)
[origin: WO2009082426A1] The present invention provides a method of stimulating the motility of the gastrointestinal system in a subject in need thereof, wherein the subject suffers from maladies (i.e., disorders, diseases, conditions, or drug- or surgery-induced dysfunction) of the gastrointestinal system, by administering to the subject a ghrelin mimetic, or pharmaceutically acceptable salt thereof. The invention also provides a method of treating a gastrointestinal malady by co-administering a ghrelin mimetic with a laxative, a H2 receptor antagonist, a serotonin receptor agonist, pure or mixed, an antacid, an opioid antagonist, a proton pump inhibitor, a motilin receptor agonist, dopamine antagonist, a cholinergic agonist, a cholinesterase inhibitor, somatostatin, octreotide, or any combination thereof.
IPC 8 full level
A61K 38/04 (2006.01); A61K 31/33 (2006.01); A61K 31/4164 (2006.01); A61K 45/06 (2006.01); A61P 1/00 (2006.01)
CPC (source: EP)
A61K 31/33 (2013.01); A61K 31/4164 (2013.01); A61K 38/25 (2013.01); A61K 45/06 (2013.01); A61P 1/00 (2017.12); A61P 1/04 (2017.12); A61P 1/10 (2017.12); A61P 1/14 (2017.12); A61P 43/00 (2017.12)
Citation (search report)
- [Y] MURRAY1 C D R ET AL: "Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled crossover study", GUT, BRITISH MEDICAL ASSOCIATION, LONDON, UK, vol. 54, 5 August 2005 (2005-08-05), pages 1693 - 1698, XP008126776, ISSN: 0017-5749, DOI: 10.1136/GUT.2005.069088
- [Y] PEETERS ET AL: "Potential of ghrelin as a therapeutic approach for gastrointestinal motility disorders", CURRENT OPINION IN PHARMACOLOGY, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 6, no. 6, 1 December 2006 (2006-12-01), pages 553 - 558, XP028058476, ISSN: 1471-4892, [retrieved on 20061201], DOI: 10.1016/J.COPH.2006.08.005
- [Y] KALINA VENKOVA ET AL: "Prokinetic Effects of a New Ghrelin Receptor Agonist TZP-101 in a Rat Model of Postoperative Ileus", DIGESTIVE DISEASES AND SCIENCES, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 52, no. 9, 10 April 2007 (2007-04-10), pages 2241 - 2248, XP019526062, ISSN: 1573-2568, DOI: 10.1007/S10620-007-9783-7
- [Y] POITRAS P ET AL: "Gastrokinetic effect of ghrelin analog RC-1139 in the rat", PEPTIDES, ELSEVIER, AMSTERDAM, vol. 26, no. 9, 1 September 2005 (2005-09-01), pages 1598 - 1601, XP027856463, ISSN: 0196-9781, [retrieved on 20050901]
- See references of WO 2009082426A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2009082426 A1 20090702; AU 2008341160 A1 20090702; CA 2709913 A1 20090702; CN 101951937 A 20110119; EP 2234630 A1 20101006; EP 2234630 A4 20120808; JP 2011507842 A 20110310; JP 2013040206 A 20130228; KR 20100102157 A 20100920; TW 200940082 A 20091001
DOCDB simple family (application)
US 2008013156 W 20081126; AU 2008341160 A 20081126; CA 2709913 A 20081126; CN 200880127235 A 20081126; EP 08864278 A 20081126; JP 2010539419 A 20081126; JP 2012250249 A 20121114; KR 20107015649 A 20081126; TW 97149342 A 20081218