EP 2243494 A1 20101027 - Pharmaceutical composition, comprising a steroid-dehydrogenase-reductase inhibitor, and a mineralocorticoid receptor antagonist.
Title (en)
Pharmaceutical composition, comprising a steroid-dehydrogenase-reductase inhibitor, and a mineralocorticoid receptor antagonist.
Title (de)
Arzneimittelzusammensetzung, enthaltend einen Steroid-dehydrogenase-reduktase-Hemmer und einen Mineralocorticoidantagonisten.
Title (fr)
Composition pharmaceutique, renfermant un inhibiteur de la steroid-déshydrogénase-reductase et un antagoniste de récepteurs de minéralocorticoide.
Publication
Application
Priority
EP 09005672 A 20090422
Abstract (en)
A treatment using a hydroxysteroid dehydrogenase reductase inhibitor combined with a mineralocorticoid receptor antagonist is provided which overcomes the problem that manipulating cortisol levels by a single compound therapy induces other pathologies or side effects, while the original condition that required treatment is ameliorated.
IPC 8 full level
A61K 45/06 (2006.01)
CPC (source: EP)
A61K 31/192 (2013.01); A61K 31/222 (2013.01); A61K 31/575 (2013.01); A61K 31/585 (2013.01); A61K 45/06 (2013.01)
Citation (applicant)
- TD PALLIN, EXPERT OPIN. THER. PATENTS, vol. 17, no. 12, 2007, pages 1407 - 1422
- KA HUGHES; SP WEBSTER; BR WALKER, EXPERT OPIN. INVEST. DRUGS, vol. 17, no. 4, 2008, pages 481 - 496
- WILKINSON-BERKA JL ET AL.: "Identification of a Retinal Aldosterone System and the Protective Effects of Mineralocorticoid Receptor Antagonism on Retinal Vascular Pathology", CIRC. RES., vol. 104, no. 1, 2009, pages 124 - 133
- RICKARD A; YOUNG M: "Corticosteroid receptors, macrophages and cardiovascular disease", J. MOL. ENDOCRINOL., vol. 08, 2009, pages 0144
- OSMOND JM; DORRANCE AM.: "11{beta}HSD2 Inhibition Causes Cerebrovascular Remodeling and Increases Infarct Size Following Cerebral Ischemia", ENDOCRINOLOGY, 2008
- ODERMATT A; GUMY C: "Glucocorticoid and mineralocorticoid action: why should we consider influences by environmental chemicals", BIOCHEM PHARMACOL, vol. 76, no. 10, 2008, pages 1184 - 93
- MOLNAR GA ET AL., GLUCOCORTICOID-RELATED SIGNALING EFFECTS IN VASCULAR SMOOTH MUSCLE CELLS. HYPERTENSION, vol. 51, no. 5, 2008, pages 1372 - 1378
- GUO C ET AL.: "Mineralocorticoid Receptor Blockade Reverses Obesity-Related Changes in Expression of Adiponectin, Peroxisome Proliferator-Activated Receptor-{gamma}, and Proinflammatory Adipokines", CIRCULATION, vol. 117, no. 17, 2008, pages 2253 - 2261
- WALKER BR.: "Glucocorticoids and Cardiovascular Disease", EUR. J. ENDOCRINOL., vol. 157, no. 5, 2007, pages 545 - 8
- CLARK AR: "Anti-inflammatory functions of glucocorticoid-induced genes", MOL CELL ENDOCRINOL, vol. 275, no. 1-2, 2007, pages 79 - 97
- CAPRIO M ET AL.: "Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis", FASEB J, vol. 21, no. 9, 2007, pages 2185 - 2194
- HULTMAN ML ET AL.: "The Ligand-Dependent Interaction of Mineralocorticoid Receptor with Coactivator and Corepressor Peptides Suggests Multiple Activation Mechanisms", MOL. ENDOCRINOL., vol. 19, no. 6, 2005, pages 1460 - 1473
- CHROUSOS GP; KINO T.: "Intracellular Glucocorticoid Signaling: A Formerly Simple System Turns Stochastic.", SCIENCE'S STKE, vol. 304, 2005, pages PE48
- WALKER EA; STEWART PM: "11 beta-hydroxysteroid dehydrogenase: unexpected connections", TRENDS ENDOCRINOL METAB, vol. 14, no. 7, 2003, pages 334 - 9
Citation (search report)
- [X] WO 2004089416 A2 20041021 - NOVO NORDISK AS [DK], et al
- [X] WO 03086410 A1 20031023 - UNIV EDINBURGH [GB], et al
- [X] US 2005014732 A1 20050120 - GULVE ERIC ARTHUR [US], et al
- [X] WO 2004096132 A2 20041111 - PHARMACIA CORP [US], et al
- [Y] WO 2006002022 A2 20060105 - IMMUSOL INC [US], et al
- [Y] SUNDBOM MAJ ET AL: "Inhibition of 11 beta HSD1 with the S-phenylethylaminothiazolone BVT116429 increases adiponectin concentrations and improves glucose homeostasis in diabetic KKAy mice", BMC PHARMACOLOGY, vol. 8, February 2008 (2008-02-01), XP002553411, ISSN: 1471-2210
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA RS
DOCDB simple family (publication)
DOCDB simple family (application)
EP 09005672 A 20090422; EP 2010002477 W 20100422