EP 2254412 A1 20101201 - MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE
Title (en)
MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE
Title (de)
MAKROZYKLISCHE LACTONVERBINDUNGEN UND VERFAHREN FÜR IHRE VERWENDUNG
Title (fr)
COMPOSÉS DE LACTONE MACROCYCLIQUES ET LEURS PROCÉDÉS D UTILISATION
Publication
Application
Priority
US 2008056501 W 20080311
Abstract (en)
[origin: WO2009114010A1] The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula (I) wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, -OH, -OP(O)Me2, (II), (III), -O-(CH2)n-OH and -O-(CH2)m-O-(CH2)o-CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of (IV) and (V) wherein each M8 is independently a member selected from the group consisting Of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of (VI), (VII) and (VIII); and salts, hydrates, isomers, metabolites, N-oxides and prodrugs thereof.
IPC 8 full level
A01N 43/04 (2006.01); A61K 31/70 (2006.01); A61P 27/02 (2006.01)
CPC (source: EP)
A61K 31/436 (2013.01); A61K 31/70 (2013.01); A61P 9/00 (2017.12); A61P 27/02 (2017.12); A61P 27/06 (2017.12); A61P 27/10 (2017.12); A61P 29/00 (2017.12); A61P 35/00 (2017.12); A61P 37/06 (2017.12)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA MK RS
DOCDB simple family (publication)
WO 2009114010 A1 20090917; BR PI0822405 A2 20180515; BR PI0822405 A8 20180605; CN 102215682 A 20111012; EP 2254412 A1 20101201; EP 2254412 A4 20120509; IL 208026 A0 20101230; JP 2011525890 A 20110929
DOCDB simple family (application)
US 2008056501 W 20080311; BR PI0822405 A 20080311; CN 200880128027 A 20080311; EP 08731883 A 20080311; IL 20802610 A 20100906; JP 2010550655 A 20080311