EP 2256500 A3 20120829 - Use of inhibitors of the enzyme TKTL1.
Title (en)
Use of inhibitors of the enzyme TKTL1.
Title (de)
Gebrauch von Inhibitoren des Enzyms TKTL1.
Title (fr)
Utilisation d'inhibiteurs de l'enzyme TKTL1.
Publication
Application
Priority
- EP 06723195 A 20060303
- EP 05004930 A 20050307
- EP 05013170 A 20050617
- EP 10009323 A 20060303
Abstract (en)
[origin: EP2256500A2] The method for qualitative and quantitative detecting of the extend of use and the correct process flow of the mammalian aerobic glucose fermentation metabolic pathway (mam-aGF) in a mammalian individual is characterized in that the enzyme TKTL1 is used as indicator and target molecule and that the structural and/or functional parameter of said TKTL1 in a biological sample of said individual (patient) are taken as indication for the qualitative and quantitative run of the mam-aGF in the cells and/or tissue of said individual (patient). In combination with the use of inhibitors and activators of that mam-aGF the method is further suitable for checking and controlling the mam-aGF in an individual (patient).
IPC 8 full level
G01N 33/68 (2006.01); C12Q 1/48 (2006.01); C12Q 1/54 (2006.01); G01N 33/573 (2006.01)
CPC (source: EP US)
A61P 1/04 (2017.12 - EP); A61P 3/04 (2017.12 - EP); A61P 3/06 (2017.12 - EP); A61P 3/08 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 17/02 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 37/02 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C12Q 1/48 (2013.01 - EP US); C12Q 1/54 (2013.01 - EP US); G01N 1/30 (2013.01 - EP US)
Citation (search report)
- [X] US 2003139331 A1 20030724 - MARTIN DANIEL S [US], et al
- [X] CARL D BENNETT ET AL: "The Role of Dietary Fat in Protecting the Rat against Oxythiamine-produced Thiamine Deficiency", THE JOURNAL OF NUTRITION, vol. 99, no. 3, 1 November 1969 (1969-11-01), pages 288 - 292, XP055020858
- [A] HEO HO JIN ET AL: "Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 52, no. 25, 15 December 2004 (2004-12-15), pages 7514 - 7517, XP002580650, ISSN: 0021-8561, [retrieved on 20041110], DOI: 10.1021/JF049243R
- [A] GEMA ALVAREZ ET AL: "Pyruvate Protection Against beta-Amyloid- Induced Neuronal Death: Role of Mitochondrial Redox State", JOURNAL OF NEUROSCIENCE RESEARCH, vol. 73, no. 2, 15 July 2003 (2003-07-15), pages 260 - 269, XP055020916
- [X] RAIS B ET AL: "Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 456, no. 1, 30 July 1999 (1999-07-30), pages 113 - 118, XP004260049, ISSN: 0014-5793, DOI: 10.1016/S0014-5793(99)00924-2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR
DOCDB simple family (publication)
EP 2256500 A2 20101201; EP 2256500 A3 20120829; EP 2256500 B1 20140423; AT E509279 T1 20110515; AU 2006222277 A1 20060914; AU 2006222277 B2 20110407; CA 2600206 A1 20060914; CA 2600206 C 20110104; DK 1856537 T3 20110718; DK 2256500 T3 20140714; EP 1856537 A1 20071121; EP 1856537 B1 20110511; ES 2480416 T3 20140728; JP 2008531065 A 20080814; JP 5095600 B2 20121212; PL 1856537 T3 20111031; PL 2256500 T3 20141031; PT 2256500 E 20140718; US 11236381 B2 20220201; US 11359225 B2 20220614; US 2008095703 A1 20080424; US 2010240687 A1 20100923; US 2020248227 A1 20200806; US 7754437 B2 20100713; WO 2006094716 A1 20060914
DOCDB simple family (application)
EP 10009323 A 20060303; AT 06723195 T 20060303; AU 2006222277 A 20060303; CA 2600206 A 20060303; DK 06723195 T 20060303; DK 10009323 T 20060303; EP 06723195 A 20060303; EP 2006001951 W 20060303; ES 10009323 T 20060303; JP 2008500098 A 20060303; PL 06723195 T 20060303; PL 10009323 T 20060303; PT 10009323 T 20060303; US 202016775454 A 20200129; US 57120506 A 20060303; US 79025710 A 20100528