Global Patent Index - EP 2264064 A1

EP 2264064 A1 20101222 - Modified exendins and exendin agonists

Title (en)

Modified exendins and exendin agonists

Title (de)

Modifizierte Exendine und Exendin Agonisten

Title (fr)

Exendines modifiées et agonistes d'exendine

Publication

EP 2264064 A1 20101222 (EN)

Application

EP 10011852 A 20000428

Priority

  • EP 00928685 A 20000428
  • US 13201899 P 19990430

Abstract (en)

Novel modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, and related formulations and dosages and methods of administration thereof are provided. These modified exendins and exendin agonists, compositions and methods are useful in treating diabetes and conditions that would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying or inhibiting food intake.

IPC 8 full level

A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61K 47/48 (2006.01); A61P 1/00 (2006.01); A61P 3/04 (2006.01); A61P 3/06 (2006.01); A61P 3/08 (2006.01); A61P 3/10 (2006.01); A61P 5/48 (2006.01); A61P 5/50 (2006.01); C07K 1/04 (2006.01); C07K 14/46 (2006.01); C07K 14/575 (2006.01)

CPC (source: EP)

A61K 47/60 (2017.07); A61P 1/00 (2017.12); A61P 3/04 (2017.12); A61P 3/06 (2017.12); A61P 3/08 (2017.12); A61P 3/10 (2017.12); A61P 5/48 (2017.12); A61P 5/50 (2017.12); C07K 14/57563 (2013.01); A61K 38/00 (2013.01)

Citation (applicant)

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Citation (search report)

  • [XI] WO 9805351 A1 19980212 - AMYLIN PHARMACEUTICALS INC [US], et al
  • [A] US 4766106 A 19880823 - KATRE NANDINI [US], et al
  • [A] US 5122614 A 19920616 - ZALIPSKY SHMUEL [US]
  • [A] WO 9808871 A1 19980305 - NOVO NORDISK AS [DK], et al
  • [XP] WO 9943708 A1 19990902 - NOVO NORDISK AS [DK], et al
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  • [A] BARRAGAN J M ET AL: "INTERACTIONS OF EXENDIN-(9-39) WITH THE EFFECTS OF GLUCAGON-LIKE PEPTIDE-1-(7-36) AMIDE AND OF EXENDIN-4 ON ARTERIAL BLOOD PRESSURE AND HEART RATE IN RATS", REGULATORY PEPTIDES, ELSEVIER SCIENCE BV, NL LNKD- DOI:10.1016/S0167-0115(96)00113-9, vol. 67, no. 1, 14 November 1996 (1996-11-14), pages 63 - 68, XP001026600, ISSN: 0167-0115
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  • [T] TSUBERY H ET AL: "PROLONGING THE ACTION OF PROTEIN AND PEPTIDE DRUGS BY A NOVEL APPROACH OF REVERSIBLE POLYETHYLENE GLYCOL MODIFICATION", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US LNKD- DOI:10.1074/JBC.M405155200, vol. 279, no. 37, 10 September 2004 (2004-09-10), pages 38118 - 38124, XP008040599, ISSN: 0021-9258

Citation (examination)

  • US 6528486 B1 20030304 - LARSEN BJARNE DUE [DK], et al
  • GOMBOTZ W R ET AL: "BIOODEGRADABLE POLYMERS FOR PROTEIN AND PEPTIDE DRUG DELIVERY", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 6, no. 4, 1 July 1995 (1995-07-01), pages 332 - 351, XP000517223, ISSN: 1043-1802, DOI: 10.1021/BC00034A002
  • EDWARDS C M B ET AL: "Glucagon-Like Peptide 1 Has a Physiological role in the control of postprandial glucose in humans", DIABETES, AMERICAN DIABETES ASSOCIATION, US, vol. 48, 1 January 1999 (1999-01-01), pages 86 - 93, XP003025993, ISSN: 0012-1797
  • AMELIE CROSET ET AL: "Differences in the glycosylation of recombinant proteins expressed in HEK and CHO cells", JOURNAL OF BIOTECHNOLOGY, vol. 161, no. 3, 1 October 2012 (2012-10-01), pages 336 - 348, XP055080422, ISSN: 0168-1656, DOI: 10.1016/j.jbiotec.2012.06.038

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 0066629 A1 20001109; AU 2004220727 A1 20041111; AU 2004220727 B2 20071011; AU 4688300 A 20001117; AU 775063 B2 20040715; AU 775063 C 20050512; BR 0010705 A 20020205; CA 2372214 A1 20001109; CN 1372570 A 20021002; EP 1175443 A1 20020130; EP 2264064 A1 20101222; JP 2002544127 A 20021224; NZ 514916 A 20040625

DOCDB simple family (application)

US 0011814 W 20000428; AU 2004220727 A 20041014; AU 4688300 A 20000428; BR 0010705 A 20000428; CA 2372214 A 20000428; CN 00809516 A 20000428; EP 00928685 A 20000428; EP 10011852 A 20000428; JP 2000615657 A 20000428; NZ 51491600 A 20000428