EP 2265261 B1 20160706 - DRUG DELIVERY SYSTEMS COMPRISING WEAKLY BASIC DRUGS AND ORGANIC ACIDS
Title (en)
DRUG DELIVERY SYSTEMS COMPRISING WEAKLY BASIC DRUGS AND ORGANIC ACIDS
Title (de)
ARZNEIABGABESYSTEME MIT SCHWACH BASISCHEN ARZNEIMITTELN UND ORGANISCHEN SÄUREN
Title (fr)
SYSTÈMES D'ADMINISTRATION DE MÉDICAMENTS COMPRENANT DES MÉDICAMENTS FAIBLEMENT BASIQUES ET DES ACIDES ORGANIQUES
Publication
Application
Priority
- US 2009036787 W 20090311
- US 3584008 P 20080312
- US 20928508 A 20080912
Abstract (en)
[origin: US2009232885A1] The present invention is directed to pharmaceutical compositions, and methods of making such compositions, wherein the compositions comprise a plurality of TPR and RR particles, wherein: the TPR particles each comprise a core coated with a TPR layer; the core comprises a weakly basic, poorly soluble drug and a pharmaceutically acceptable organic acid separated from each other by an SR layer; the RR particles each comprise the weakly basic, poorly soluble drug, and release at least about 80 wt.% of the weakly basic, poorly soluble drug in about 5 minutes when dissolution tested using United States Pharmacopoeia (USP) dissolution methodology (Apparatus 2-paddles@ 50 RPM and a two-stage dissolution medium at 37° C., (first 2 hours in 0.1N HCl followed by testing in a buffer at pH 6.8).
IPC 8 full level
A61K 9/30 (2006.01); A61K 9/16 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61K 9/50 (2006.01)
CPC (source: EP US)
A61K 9/1617 (2013.01 - EP US); A61K 9/1623 (2013.01 - EP US); A61K 9/1635 (2013.01 - EP US); A61K 9/1652 (2013.01 - EP US); A61K 9/1676 (2013.01 - EP US); A61K 9/2081 (2013.01 - EP US); A61K 9/48 (2013.01 - EP US); A61K 9/5042 (2013.01 - EP US); A61K 9/5078 (2013.01 - EP US); A61K 9/5084 (2013.01 - EP US); A61K 31/4178 (2013.01 - EP US); A61P 1/08 (2017.12 - EP); A61P 43/00 (2017.12 - EP)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
US 2009232885 A1 20090917; US 8133506 B2 20120313; AR 071562 A1 20100630; AU 2009223019 A1 20090917; AU 2009223019 B2 20131003; AU 2009223019 C1 20150507; BR PI0908942 A2 20170919; CA 2718257 A1 20090917; CA 2718257 C 20160719; CL 2009000598 A1 20090821; CN 101977593 A 20110216; CN 101977593 B 20140806; DK 2265261 T3 20161003; EP 2265261 A1 20101229; EP 2265261 A4 20130703; EP 2265261 B1 20160706; ES 2590479 T3 20161122; HU E029680 T2 20170228; IL 208089 A0 20101230; JP 2011513498 A 20110428; JP 5634882 B2 20141203; KR 101660927 B1 20160928; KR 20100129756 A 20101209; MX 2010010052 A 20110125; NZ 587897 A 20121026; PL 2265261 T3 20170131; PT 2265261 T 20160914; RU 2010141726 A 20120420; RU 2504362 C2 20140120; SA 109300166 B1 20130704; SG 10201405929U A 20141127; TW 200942273 A 20091016; TW I440480 B 20140611; WO 2009114606 A1 20090917; ZA 201006557 B 20111228
DOCDB simple family (application)
US 20928508 A 20080912; AR P090100890 A 20090312; AU 2009223019 A 20090311; BR PI0908942 A 20090311; CA 2718257 A 20090311; CL 2009000598 A 20090312; CN 200980108774 A 20090311; DK 09718989 T 20090311; EP 09718989 A 20090311; ES 09718989 T 20090311; HU E09718989 A 20090311; IL 20808910 A 20100912; JP 2010550837 A 20090311; KR 20107022295 A 20090311; MX 2010010052 A 20090311; NZ 58789709 A 20090311; PL 09718989 T 20090311; PT 09718989 T 20090311; RU 2010141726 A 20090311; SA 109300166 A 20090314; SG 10201405929U A 20090311; TW 98107970 A 20090311; US 2009036787 W 20090311; ZA 201006557 A 20100913