EP 2265598 A2 20101229 - NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME, AND USE THEREOF
Title (en)
NOVEL HSP90 INHIBITORY CARBAZOLE DERIVATIVES, COMPOSITIONS CONTAINING SAME, AND USE THEREOF
Title (de)
NEUARTIGE HSP90-HEMMENDE CARBAZOLDERIVATE, ZUSAMMENSETZUNGEN DAMIT UND VERWENDUNG DAVON
Title (fr)
NOUVEAUX DERIVES DE CARBAZOLE INHIBITEURS D' HSP90, COMPOSITIONS LES CONTENANT ET UTILISATION
Publication
Application
Priority
- FR 2009000267 W 20090313
- FR 0801394 A 20080314
Abstract (en)
[origin: TW200938541A] The invention relates to the novel products of formula (I): in which Het represents a heterocycle optionally substituted with one or more radicals R1 or R'1, R is chosen from the group constituted of: with R1 and/or R'1, chosen from H, halogen, CF3, nitro, cyano, alkyl, hydroxyl, mercapto, amino, alkylamino, dialkylamino, alkoxy, phenylalkoxy, alkylthio, carboxyl in free form or esterified with an alkyl radical, carboxamide, CO-NH(alkyl), CON(alkyl)2, NH-CO-alkyl, sulphonamide, NH-SO2-alkyl, S(O)2-NHalkyl and S(O2)-N(alkyl)2; all these radicals being optionally substituted; W1, W2 and W3 independently represent CH or N; X represents O, S, NR2, C(O), S(O) or S(O)2; Z represents H, Hal, -O-R2 or-NH-R2, with R2 represents H, or alkyl, cycloalkyl or heterocycloalkyl, which is optionally substituted; these products being in all the isomeric forms and the salts, as medicaments.
IPC 8 full level
C07D 401/04 (2006.01); A61K 31/4184 (2006.01); A61K 31/437 (2006.01); A61K 31/4709 (2006.01); A61P 35/00 (2006.01); C07D 209/88 (2006.01); C07D 213/16 (2006.01); C07D 215/12 (2006.01); C07D 231/56 (2006.01); C07D 233/64 (2006.01); C07D 235/18 (2006.01); C07D 261/20 (2006.01); C07D 401/10 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/10 (2006.01); C07D 403/14 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP US)
A61P 7/02 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 17/06 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/14 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 31/00 (2017.12 - EP); A61P 31/10 (2017.12 - EP); A61P 31/12 (2017.12 - EP); A61P 31/14 (2017.12 - EP); A61P 31/20 (2017.12 - EP); A61P 31/22 (2017.12 - EP); A61P 33/02 (2017.12 - EP); A61P 33/06 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 35/04 (2017.12 - EP); C07D 401/04 (2013.01 - EP US); C07D 401/14 (2013.01 - EP US); C07D 403/04 (2013.01 - EP US); C07D 403/14 (2013.01 - EP US); C07D 405/14 (2013.01 - EP US); C07D 413/14 (2013.01 - EP US); C07D 451/04 (2013.01 - EP US); C07D 453/00 (2013.01 - EP US); C07D 471/04 (2013.01 - EP US); C07D 493/08 (2013.01 - EP US)
Citation (search report)
See references of WO 2009122034A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA RS
DOCDB simple family (publication)
FR 2928645 A1 20090918; AR 070836 A1 20100505; AU 2009232121 A1 20091008; BR PI0909731 A2 20190306; CA 2718488 A1 20091008; CL 2009000619 A1 20110218; CN 102026992 A 20110420; CO 6251295 A2 20110221; CR 11653 A 20101122; DO P2010000272 A 20101015; EA 201071078 A1 20110429; EC SP10010473 A 20101030; EP 2265598 A2 20101229; IL 208059 A0 20101230; JP 2011513473 A 20110428; JP 5674483 B2 20150225; KR 20100130603 A 20101213; MA 32206 B1 20110401; MX 2010010018 A 20101215; NI 201000150 A 20110329; PE 20091673 A1 20091114; TW 200938541 A 20090916; US 2011166169 A1 20110707; US 8309721 B2 20121113; UY 31711 A 20091110; WO 2009122034 A2 20091008; WO 2009122034 A3 20091203; WO 2009122034 A8 20100819
DOCDB simple family (application)
FR 0801394 A 20080314; AR P090100879 A 20090312; AU 2009232121 A 20090313; BR PI0909731 A 20090313; CA 2718488 A 20090313; CL 2009000619 A 20090313; CN 200980117438 A 20090313; CO 10108118 A 20100901; CR 11653 A 20100826; DO 2010000272 A 20100910; EA 201071078 A 20090313; EC SP10010473 A 20100910; EP 09728587 A 20090313; FR 2009000267 W 20090313; IL 20805910 A 20100907; JP 2010550234 A 20090313; KR 20107020403 A 20090313; MA 33221 A 20101006; MX 2010010018 A 20090313; NI 201000150 A 20100909; PE 2009000368 A 20090312; TW 98108083 A 20090312; US 88141410 A 20100914; UY 31711 A 20090313