EP 2272817 A4 20111214 - PAI-1 INHIBITOR
Title (en)
PAI-1 INHIBITOR
Title (de)
PAI-1-HEMMER
Title (fr)
INHIBITEUR DE PAI-1
Publication
Application
Priority
- JP 2009001695 W 20090413
- JP 2008104152 A 20080411
Abstract (en)
[origin: EP2272817A1] The compound represented by the following formula (I) and the like have PAI-1 inhibition activity; wherein: R 1 represents a C 6-10 aryl group which may be substituted or the like; T represents a single bond or the like; m represents 0 or 1; when m is 0, G represents -N-C(=O)-CO 2 H or the like; when m is 1, G represents an oxygen atom or the like; R 2 represents a C 6-10 aryl group which may be substituted or the like; E represents the following formula (II) wherein one of R 31 , R 32 , R 33 and R 34 represents the formula R 1 -T-, each of the other three independently represents a hydrogen atom or the like, and R 35 represents the formula -X-Y', a hydrogen atom or the like; X represents -CH 2 - or the like; Y' represents a carboxy group or the like; M represents a single bond or the like.
IPC 8 full level
A61K 31/192 (2006.01); A61K 31/196 (2006.01); A61K 31/197 (2006.01); A61K 31/36 (2006.01); A61K 31/402 (2006.01); A61K 31/41 (2006.01); A61K 31/4453 (2006.01); A61K 31/451 (2006.01); A61K 31/495 (2006.01); A61K 31/54 (2006.01); A61K 31/55 (2006.01); C07C 59/66 (2006.01); C07C 59/68 (2006.01); C07C 59/70 (2006.01); C07C 65/24 (2006.01); C07C 205/56 (2006.01); C07C 229/42 (2006.01); C07C 233/25 (2006.01); C07C 233/56 (2006.01)
CPC (source: EP)
A61P 7/02 (2017.12); A61P 43/00 (2017.12); C07C 59/66 (2013.01); C07C 59/68 (2013.01); C07C 59/70 (2013.01); C07C 65/24 (2013.01); C07C 69/712 (2013.01); C07C 69/736 (2013.01); C07C 69/76 (2013.01); C07C 205/37 (2013.01); C07C 217/80 (2013.01); C07C 217/84 (2013.01); C07C 233/15 (2013.01); C07C 233/29 (2013.01); C07C 233/51 (2013.01); C07C 233/56 (2013.01); C07C 235/38 (2013.01); C07C 235/40 (2013.01); C07C 235/68 (2013.01); C07C 235/80 (2013.01); C07C 255/54 (2013.01); C07C 311/08 (2013.01); C07C 311/29 (2013.01); C07C 317/22 (2013.01); C07C 323/12 (2013.01); C07C 323/22 (2013.01); C07C 323/41 (2013.01); C07C 323/62 (2013.01); C07D 211/42 (2013.01); C07D 257/04 (2013.01); C07D 295/12 (2013.01); C07D 317/54 (2013.01); C07C 2601/08 (2017.04); C07C 2601/14 (2017.04); C07C 2601/18 (2017.04); C07C 2603/74 (2017.04)
Citation (search report)
- [X] WO 2004024939 A2 20040325 - UNIV GEORGETOWN [US], et al
- [X] EP 1431267 A1 20040623 - ONO PHARMACEUTICAL CO [JP]
- [A] EP 0544488 A2 19930602 - LILLY CO ELI [US]
- See references of WO 2009125606A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
EP 2272817 A1 20110112; EP 2272817 A4 20111214; AU 2009234899 A1 20091015; BR PI0906348 A2 20190716; CA 2720096 A1 20091015; CN 102137837 A 20110727; JP 2014144953 A 20140814; JP 6041396 B2 20161207; JP WO2009125606 A1 20110804; KR 20100132073 A 20101216; RU 2010145916 A 20120520; WO 2009125606 A1 20091015
DOCDB simple family (application)
EP 09729613 A 20090413; AU 2009234899 A 20090413; BR PI0906348 A 20090413; CA 2720096 A 20090413; CN 200980113077 A 20090413; JP 2009001695 W 20090413; JP 2010507180 A 20090413; JP 2014004588 A 20140114; KR 20107025193 A 20090413; RU 2010145916 A 20090413