EP 2276474 A1 20110126 - SOLID ORAL FORM WITH DUAL RELEASE PROFILE, CONTAINING MULTIPARTICULATES
Title (en)
SOLID ORAL FORM WITH DUAL RELEASE PROFILE, CONTAINING MULTIPARTICULATES
Title (de)
FESTE ORALE MULTIPARTIKELHALTIGE DARREICHUNGSFORM MIT ZWEIFACHEM FREISETZUNGSPROFIL
Title (fr)
FORME ORALE SOLIDE DOTEE D'UN DOUBLE PROFIL DE LIBERATION COMPRENANT DES MULTIPARTICULES
Publication
Application
Priority
- FR 2009050719 W 20090417
- FR 0852627 A 20080418
- US 7125008 P 20080418
Abstract (en)
[origin: WO2009138642A1] The invention relates to a solid form intended for the oral administration of at least one active agent and capable of ensuring a dual mechanism for the release of said active agent, whereby the first release is conditioned by time and the second release is conditioned by pH. The invention is characterised in that the active agent is present in the form of a microparticulate system, the microparticulates of which include a core which is made up entirely or partly of said active agent and coated with at least one layer which conditions the release profile of the active agent and which is formed by a material containing at least: (i) 25% to 75% by weight, relative to the total weight of the coating, of at least a polymer A that is insoluble in the gastrointestinal fluids, (ii) 25% to 75% by weight, relative to the total weight of the coating, of at least a polymer B that has a solubilisation pH value in the pH range of from 5 to 7, and (iii) 0 to 25% by weight, relative to the total weight of the coating, of at least one plasticiser, said polymers A and B being present in a polymer(s) B/polymer(s) A weight ratio that is at least equal to 0.25. The invention also relates to a method for preparing this solid form and the corresponding microparticulates.
IPC 8 full level
A61K 9/26 (2006.01); A61K 9/52 (2006.01); A61K 9/58 (2006.01); A61K 9/62 (2006.01)
CPC (source: EP US)
A61K 9/2081 (2013.01 - EP US); A61K 9/5026 (2013.01 - EP US); A61K 9/5047 (2013.01 - EP US); A61K 9/5078 (2013.01 - EP US); A61K 9/5084 (2013.01 - EP US)
Citation (search report)
See references of WO 2009138642A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA RS
DOCDB simple family (publication)
FR 2930147 A1 20091023; FR 2930147 B1 20130208; AU 2009247921 A1 20091119; AU 2009247921 B2 20130905; BR PI0910572 A2 20170808; BR PI0910572 B1 20211013; CA 2721232 A1 20091119; CA 2721232 C 20160329; CN 102046155 A 20110504; EP 2276474 A1 20110126; EP 2276474 B1 20190306; ES 2721849 T3 20190805; IL 208572 A0 20101230; IL 208572 A 20160229; JP 2011518139 A 20110623; JP 5687185 B2 20150318; KR 101380507 B1 20140411; KR 20110005876 A 20110119; MX 2010011409 A 20101202; MX 339671 B 20160603; US 2009291137 A1 20091126; WO 2009138642 A1 20091119; ZA 201007238 B 20110629
DOCDB simple family (application)
FR 0852627 A 20080418; AU 2009247921 A 20090417; BR PI0910572 A 20090417; CA 2721232 A 20090417; CN 200980120252 A 20090417; EP 09745961 A 20090417; ES 09745961 T 20090417; FR 2009050719 W 20090417; IL 20857210 A 20101007; JP 2011504516 A 20090417; KR 20107025760 A 20090417; MX 2010011409 A 20090417; US 42587509 A 20090417; ZA 201007238 A 20101011