EP 2277996 A2 20110126 - Methods for producing preparations of recombinant AAV virions substantially free of empty capsids

Title (en)

Methods for producing preparations of recombinant AAV virions substantially free of empty capsids

Title (de)

VERFAHREN ZUR HERSTELLUNG VON PRÄPARATIONEN REKOMBINANTER AAV-VIRIONEN, DIE WEITGEHEND FREI VON LEEREN CAPSIDEN SIND

Title (fr)

PROCEDES DE PRODUCTION DE PREPARATIONS DE VIRIONS AAV RECOMBINANTS SENSIBLEMENT EXEMPTES DE CAPSIDES VIDES

Publication

EP 2277996 A2 20110126 (EN)

Application

EP 10179750 A 20040521

Priority

EP 04776068 A 20040521
US 47238403 P 20030521
US 54975604 P 20040302

Abstract (en)

Methods for separating AAV empty capsids from mixtures of AAV vector particles and AAV empty capsids are described. The methods use column chromatography techniques and provide for commercially viable levels of recombinant AAV virions.

IPC 8 full level

C12N 7/02 (2006.01); B01D 15/00 (2006.01); B01D 15/04 (2006.01); C02F 1/42 (2006.01); C12N 15/86 (2006.01); C12N 15/864 (2006.01)

IPC 8 main group level

C12N (2006.01)

CPC (source: EP US)

C12N 7/00 (2013.01 - EP US); C12N 15/86 (2013.01 - EP US); C12N 2710/10351 (2013.01 - US); C12N 2710/16651 (2013.01 - US); C12N 2750/14143 (2013.01 - EP US); C12N 2750/14151 (2013.01 - EP US); C12N 2760/16051 (2013.01 - US)

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Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PL PT RO SE SI SK TR

DOCDB simple family (publication)

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DOCDB simple family (application)

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