EP 2279250 A4 20111012 - FUSION MOLECULES OF RATIONALLY-DESIGNED DNA-BINDING PROTEINS AND EFFECTOR DOMAINS
Title (en)
FUSION MOLECULES OF RATIONALLY-DESIGNED DNA-BINDING PROTEINS AND EFFECTOR DOMAINS
Title (de)
FUSIONSMOLEKÜLE VON DNA-BINDENDEN PROTEINEN MIT RATIONALEM DESIGN UND EFFEKTOR-DOMÄNEN
Title (fr)
MOLÉCULES DE FUSION DE PROTÉINES DE LIAISON À L'ADN ET DE DOMAINES EFFECTEURS CONÇUS DE FAÇON RATIONNELLE
Publication
Application
Priority
- US 2009041796 W 20090427
- US 4849908 P 20080428
Abstract (en)
[origin: WO2009134714A2] Targeted transcriptional effectors (transcription activators and transcription repressors) derived from meganucleases are described. Also described are nucleic acids encoding same, and methods of using same to regulate gene expression. The targeted transcriptional effectors can comprise (i) a meganuclease DNA-binding domain lacking endonuclease cleavage activity that binds to a target recognition site; and (ii) a transcription effector domain.
IPC 8 full level
CPC (source: EP US)
A61P 35/00 (2017.12 - EP); C12N 9/22 (2013.01 - EP US); A61K 48/00 (2013.01 - EP US)
Citation (search report)
- [A] CHEVALIER BRETT ET AL: "Metal-dependent DNA cleavage mechanism of the I-CreI LAGLIDADG homing endonuclease", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 43, no. 44, 9 November 2004 (2004-11-09), pages 14015 - 14026, XP002412602, ISSN: 0006-2960, DOI: 10.1021/BI048970C
- See references of WO 2009134714A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2009134714 A2 20091105; WO 2009134714 A3 20100128; AU 2009241351 A1 20091105; CA 2722797 A1 20091105; EP 2279250 A2 20110202; EP 2279250 A4 20111012; JP 2011519558 A 20110714; US 2011123509 A1 20110526
DOCDB simple family (application)
US 2009041796 W 20090427; AU 2009241351 A 20090427; CA 2722797 A 20090427; EP 09739516 A 20090427; JP 2011507554 A 20090427; US 91401410 A 20101028