Global Patent Index - EP 2282767 A2

EP 2282767 A2 20110216 - SITE-DIRECTED MODIFICATION OF FACTOR IX

Title (en)

SITE-DIRECTED MODIFICATION OF FACTOR IX

Title (de)

ORTSGERICHTETE MODIFIZIERUNG VON FAKTOR IX

Title (fr)

MODIFICATION DE FACTEUR IX ORIENTÉE SITE

Publication

EP 2282767 A2 20110216 (EN)

Application

EP 09747101 A 20090415

Priority

  • US 2009040691 W 20090415
  • US 12456808 P 20080416

Abstract (en)

[origin: WO2009140015A2] The invention relates to modified Factor IX polypeptides such as Factor IX polypeptides with one or more introduced cysteine sites. The modified Factor IX polypeptides may be conjugated to a biocompatible polymer. The invention also relates to methods of making modified Factor IX polypeptides, and methods of using modified Factor IX polypeptides, for example, to treat patients afflicted with hemophilia B.

IPC 8 full level

A61K 38/48 (2006.01); C12N 9/64 (2006.01)

CPC (source: EP)

A61K 47/60 (2017.08); A61P 7/04 (2018.01); C12N 9/644 (2013.01); C12Y 304/21022 (2013.01); A61K 38/00 (2013.01)

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA RS

DOCDB simple family (publication)

WO 2009140015 A2 20091119; WO 2009140015 A3 20100107; CA 2721362 A1 20091119; CN 102065887 A 20110518; EP 2282767 A2 20110216; EP 2282767 A4 20120711; JP 2011517950 A 20110623; KR 20110015551 A 20110216

DOCDB simple family (application)

US 2009040691 W 20090415; CA 2721362 A 20090415; CN 200980122785 A 20090415; EP 09747101 A 20090415; JP 2011505176 A 20090415; KR 20107025563 A 20090415