EP 2297075 A1 20110323 - DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION
Title (en)
DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION
Title (de)
DIHYDROISO-CA-4 UND ANALOGA: WIRKSAME CYTOTOXISCHE VERBINDUNGEN, INHIBITOREN DER TUBULINPOLYMERISATION
Title (fr)
DIHYDRO ISO CA-4 ET ANALOGUES : PUISSANTS CYTOTOXIQUES, INHIBITEURS DE LA POLYMERISATION DE LA TUBULINE
Publication
Application
Priority
- EP 2009056885 W 20090604
- FR 0853694 A 20080604
Abstract (en)
[origin: WO2009147217A1] The present invention relates to compounds of formula (I) below in which: - R1 and R3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms, - R2 and R4 represent, independently of one another, a hydrogen atom or a methoxy group optionally substituted by one or more fluorine atoms, - A represents a ring chosen from the group comprising aryl and heteroaryl groups, said ring possibly being substituted by or fused to a heterocycle, - X represents a nitrogen atom or a CH group, and - Z1 represents a hydrogen atom or a halogen atom, preferably fluorine, and - Z2 represents a hydrogen atom, a halogen atom, preferably fluorine, a C1 to C4 alkyl group, an aryl group or a -CN, -SO2NR12R13, -SO2R9, -COOR15 or -COR15 group, and also to the pharmaceutically acceptable salts thereof, the isomers thereof and the prodrugs thereof.
IPC 8 full level
C07C 43/20 (2006.01); A61K 31/09 (2006.01); A61K 31/136 (2006.01); A61K 31/222 (2006.01); A61K 31/277 (2006.01); A61K 31/295 (2006.01); A61P 35/00 (2006.01); C07C 69/013 (2006.01); C07C 217/00 (2006.01); C07C 229/12 (2006.01); C07C 255/37 (2006.01); C07C 271/44 (2006.01); C07D 209/12 (2006.01); C07D 317/54 (2006.01); C07F 9/12 (2006.01)
CPC (source: EP US)
A61P 17/06 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07C 41/16 (2013.01 - EP US); C07C 41/18 (2013.01 - EP US); C07C 41/20 (2013.01 - EP US); C07C 41/30 (2013.01 - EP US); C07C 43/2055 (2013.01 - EP US); C07C 43/225 (2013.01 - EP US); C07C 43/23 (2013.01 - EP US); C07C 69/013 (2013.01 - EP US); C07C 217/80 (2013.01 - EP US); C07C 217/84 (2013.01 - EP US); C07C 217/90 (2013.01 - EP US); C07C 217/92 (2013.01 - EP US); C07C 229/12 (2013.01 - EP US); C07C 233/25 (2013.01 - EP US); C07C 255/37 (2013.01 - EP US); C07C 271/22 (2013.01 - EP US); C07C 271/44 (2013.01 - EP US); C07D 209/12 (2013.01 - EP US); C07D 213/64 (2013.01 - EP US); C07D 213/74 (2013.01 - EP US); C07D 215/14 (2013.01 - EP US); C07D 215/38 (2013.01 - EP US); C07D 307/80 (2013.01 - EP US); C07D 311/12 (2013.01 - EP US); C07D 317/54 (2013.01 - EP US); C07D 473/34 (2013.01 - EP US); C07F 9/12 (2013.01 - EP US); C07C 2603/18 (2017.04 - EP US)
Citation (search report)
See references of WO 2009147217A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA RS
DOCDB simple family (publication)
WO 2009147217 A1 20091210; CA 2726907 A1 20091210; EP 2297075 A1 20110323; FR 2932180 A1 20091211; FR 2932180 B1 20120810; JP 2011523657 A 20110818; US 2011160228 A1 20110630
DOCDB simple family (application)
EP 2009056885 W 20090604; CA 2726907 A 20090604; EP 09757598 A 20090604; FR 0853694 A 20080604; JP 2011512131 A 20090604; US 99648809 A 20090604