EP 2297341 A4 20130109 - METHODS AND COMPOSITIONS FOR THE TREATMENT OF HUNTINGTON'S DISEASE
Title (en)
METHODS AND COMPOSITIONS FOR THE TREATMENT OF HUNTINGTON'S DISEASE
Title (de)
VERFAHREN UND ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VON MORBUS HUNTINGTON
Title (fr)
PROCÉDÉS ET COMPOSITIONS POUR LE TRAITEMENT DE LA MALADIE DE HUNTINGTON
Publication
Application
Priority
- CA 2009000645 W 20090508
- US 71465208 P 20080509
Abstract (en)
[origin: WO2009135322A1] Methods and compositions for reducing expression of a mutant huntingtin (mHTT) protein in a cell are provided. Such methods include contacting the cell with an effective amount of a nucleic acid silencing agent targeting a differentiating polymorphism in RNA encoding the mHTT.
IPC 8 full level
C12Q 1/68 (2006.01); A61K 31/7088 (2006.01); A61K 31/713 (2006.01); A61P 25/14 (2006.01); C07H 21/00 (2006.01); C12N 15/113 (2010.01); C12N 15/63 (2006.01); C12N 15/85 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
A61K 31/713 (2013.01); A61P 25/14 (2017.12); C12N 15/113 (2013.01); A61K 48/00 (2013.01); C12N 2310/11 (2013.01)
Citation (search report)
- [E] US 2010299768 A1 20101125 - PERRIN VALERIE [CH], et al
- [Y] US 2002187931 A1 20021212 - HAYDEN MICHAEL [CA], et al
- [XY] DENOVAN-WRIGHT E M ET AL: "RNAi: a potential therapy for the dominantly inherited nucleotide repeat diseases", GENE THERAPY, MACMILLAN PRESS LTD., BASINGSTOKE, GB, vol. 13, no. 6, 1 March 2006 (2006-03-01), pages 525 - 531, XP002452333, ISSN: 0969-7128
- See references of WO 2009135322A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2009135322 A1 20091112; AU 2009244013 A1 20091112; AU 2009244013 B2 20150625; CA 2726866 A1 20091112; EP 2297341 A1 20110323; EP 2297341 A4 20130109
DOCDB simple family (application)
CA 2009000645 W 20090508; AU 2009244013 A 20090508; CA 2726866 A 20090508; EP 09741640 A 20090508