EP 2299820 A4 20121114 - OPHTHALMIC FORMULATION OF RHO KINASE INHIBITOR COMPOUND
Title (en)
OPHTHALMIC FORMULATION OF RHO KINASE INHIBITOR COMPOUND
Title (de)
OPHTHALMISCHE FORMULIERUNG EINER RHO-KINASEHEMMERVERBINDUNG
Title (fr)
FORMULATION OPHTALMOLOGIQUE DE COMPOSÉ D'INHIBITEUR DE LA KINASE RHO
Publication
Application
Priority
- US 2009047108 W 20090611
- US 7351908 P 20080618
Abstract (en)
[origin: WO2009155209A1] The present invention relates to an aqueous pharmaceutical formulation comprising at least one inhibitor of Rho-associated protein kinase (ROCK). The aqueous pharmaceutical formulation comprises 0.01-0.4% w/v of ROCK inhibitor(s), a non-ionic surfactant in an amount of 0.01-2% w/v, and a tonicity agent to maintain a tonicity between 220-360 mOsm/kG, at a pH between 6.3 to 7.8, wherein the ROCK inhibitor, the surfactant, and the tonicity agent are compatible in the formulation. The aqueous ophthalmic formulations of this invention have an increased ocular bioavailability and/or aqueous humor concentrations without a concomitant increase in systemic concentrations. The present invention further provides a method of reducing intraocular pressure, particularly a method of treating glaucoma, by administering the aqueous pharmaceutical formulation to a subject.
IPC 8 full level
A61K 9/08 (2006.01); A61K 31/416 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/4725 (2006.01)
CPC (source: EP)
A61K 9/0048 (2013.01); A61K 31/416 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/4725 (2013.01); A61P 27/06 (2017.12); A61P 43/00 (2017.12)
Citation (search report)
- [A] EP 1256574 A1 20021113 - KIRIN BREWERY [JP]
- [A] US 2007149548 A1 20070628 - HELLBERG MARK R [US], et al
- See references of WO 2009155209A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2009155209 A1 20091223; EP 2299820 A1 20110330; EP 2299820 A4 20121114; JP 2011524912 A 20110908
DOCDB simple family (application)
US 2009047108 W 20090611; EP 09767519 A 20090611; JP 2011514714 A 20090611