EP 2300446 B1 20111207 - EFFICIENT PRODUCTION OF HETEROLOGOUS PROTEINS USING MANNOSYL TRANSFERASE INHIBITORS
Title (en)
EFFICIENT PRODUCTION OF HETEROLOGOUS PROTEINS USING MANNOSYL TRANSFERASE INHIBITORS
Title (de)
EFFIZIENTE HERSTELLUNG HETEROLOGER PROTEINE UNTER VERWENDUNG VON MANNOSYLTRANSFERASEINHIBITOREN
Title (fr)
PRODUCTION EFFICACE DE PROTEINES HETEROLOGUES A L'AIDE D'INHIBITEURS DE LA MANNOSYL TRANSFERASE
Publication
Application
Priority
- US 2009044297 W 20090518
- US 12825108 P 20080520
Abstract (en)
[origin: US8765409B2] Compounds and methods are described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of certain benzylidene thiazolidinediones inhibitors of Pmt-mediated O-linked glycosylation.
IPC 8 full level
C07D 277/36 (2006.01); C12P 21/02 (2006.01)
CPC (source: EP US)
C07D 277/36 (2013.01 - EP US); C12P 21/005 (2013.01 - US); C12P 21/02 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2009143041 A1 20091126; AT E536347 T1 20111215; AU 2009249314 A1 20091126; CA 2721459 A1 20091126; CN 102036974 A 20110427; CN 102036974 B 20140723; EP 2300446 A1 20110330; EP 2300446 B1 20111207; JP 2011520968 A 20110721; JP 2014055157 A 20140327; JP 5411929 B2 20140212; MX 2010012626 A 20110222; US 2011076721 A1 20110331; US 2013316398 A1 20131128; US 8309325 B2 20121113; US 8765409 B2 20140701
DOCDB simple family (application)
US 2009044297 W 20090518; AT 09751270 T 20090518; AU 2009249314 A 20090518; CA 2721459 A 20090518; CN 200980118628 A 20090518; EP 09751270 A 20090518; JP 2011510611 A 20090518; JP 2013231654 A 20131108; MX 2010012626 A 20090518; US 201213588022 A 20120817; US 99371609 A 20090518