EP 2303245 A2 20110406 - DEGRADABLE MICROCAPSULES
Title (en)
DEGRADABLE MICROCAPSULES
Title (de)
ABBAUBARE MIKROKAPSELN
Title (fr)
MICROCAPSULES DÉGRADABLES
Publication
Application
Priority
- EP 2009058792 W 20090710
- EP 08104713 A 20080711
- EP 09780410 A 20090710
Abstract (en)
[origin: WO2010004018A2] The invention relates to microcapsules consisting of a polymer degradable by a polypeptide comprising a drug or other compound of interest and a genetically engineered cell expressing said polypeptide in response to a triggering compound, and to methods of directed release of the compound of interest. The preferred polymer is optionally modified cellulose sulfate / poly-diallyl-dimethyl-ammonium chloride. Such microcapsules are non-toxic, do not elicit an immunological response and have an extended half-life time in mammals. The expression system for cellulase is, for example, based on TET and doxycycline, or E.REX and erythromycin. In another example, expression of cellulase is triggered by luteinizing hormone, which can be used for artificial insemination with microcapsules carrying sperm.
IPC 8 full level
A61K 9/50 (2006.01); A61K 35/52 (2015.01)
CPC (source: EP US)
A61K 9/5042 (2013.01 - EP US); A61K 9/5068 (2013.01 - EP US); A61K 35/52 (2013.01 - EP US); A61P 15/00 (2017.12 - EP)
Citation (search report)
See references of WO 2010004018A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Designated extension state (EPC)
AL BA RS
DOCDB simple family (publication)
WO 2010004018 A2 20100114; WO 2010004018 A3 20100923; CA 2730292 A1 20100114; CA 2730292 C 20160614; EP 2303245 A2 20110406; EP 2303245 B1 20161228; US 2011177162 A1 20110721; US 2013045190 A1 20130221; US 8388945 B2 20130305; US 8506950 B2 20130813
DOCDB simple family (application)
EP 2009058792 W 20090710; CA 2730292 A 20090710; EP 09780410 A 20090710; US 200913003420 A 20090710; US 201213605307 A 20120906