Global Patent Index - EP 2303848 A2

EP 2303848 A2 20110406 - URACIL DERIVATIVES AND USE THEREOF

Title (en)

URACIL DERIVATIVES AND USE THEREOF

Title (de)

URACILDERIVATE UND DEREN VERWENDUNG

Title (fr)

DÉRIVÉS DE L'URACILE ET LEUR UTILISATION

Publication

EP 2303848 A2 20110406 (DE)

Application

EP 09769031 A 20090625

Priority

  • EP 2009004698 W 20090625
  • DE 102008030091 A 20080625

Abstract (en)

[origin: WO2009156182A2] The invention relates to uracil derivatives and use thereof as therapeutic agents. The uracil derivatives are used in particular together with a cytostatic agent for suppressing or reducing resistance building up on cytostatic treatment.

IPC 8 full level

C07D 239/22 (2006.01); C07D 239/54 (2006.01)

CPC (source: EP US)

A61P 35/00 (2017.12 - EP); C07D 239/22 (2013.01 - EP US); C07D 239/54 (2013.01 - EP US)

Citation (search report)

See references of WO 2009156182A2

Citation (examination)

  • WO 2006009734 A1 20060126 - WYETH CORP [US], et al
  • WO 0155119 A2 20010802 - NEUROCRINE BIOSCIENCES INC [US], et al
  • EP 0392298 A2 19901017 - BAYER AG [DE]
  • M. R. ATKINSON ET AL: "795. Purines, pyrimidines, and glyoxalines. Part IV. Cyanouracils from amines and amino-acids", JOURNAL OF THE CHEMICAL SOCIETY, 1 January 1956 (1956-01-01), LETCHWORTH; GB, pages 4118, XP055310403, ISSN: 0368-1769, DOI: 10.1039/jr9560004118
  • ULLA HENRIKSEN: "Facile Synthesis of N-(1-Alkenyl) Derivatives of 2,4-Pyrimidinediones", NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS., vol. 19, no. 7, 1 July 2000 (2000-07-01), US, pages 1093 - 1100, XP055310406, ISSN: 1525-7770, DOI: 10.1080/15257770008035032
  • V ESCHENFELDER, R BROSSMER: "Mono-, Di- und Triallyliertes 5-(Hydroxylmethyl)uracil", LIEBIGS ANNALEN DER CHEMIE, 1 January 1977 (1977-01-01), pages 1969 - 1975
  • M YOSHIMOTO, C HANSCH: "Correlation Analysis of Baker's Studies on Enzyme Inhibition. 2. Chymotrypsin, Trypsin, Thymidine Phosphorylase, Uridine Phosphorylase, Thymidylate Synthetase, Cytosine Nucleoside Deaminase, Dihydrofolate Reductase, Malate Dehydrogenase, Glutamate Dehydrogenase, Lactate Dehydrogenase, and Glyceralde", JOURNAL OF MEDICINAL CHEMISTRY, vol. 19, no. 1, 1 January 1976 (1976-01-01), pages 71 - 98, XP000609047, DOI: doi:10.1021/jm00223a015
  • NOEL J CUSACK ET AL: "Purines, pyrimidines, and imidazoles. XL. New synthesis of a D-ribofuranosylamine derivative and its use in the synthesis of pyrimidine and imidazole nucleosides", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, no. 16, 1 January 1973 (1973-01-01), GB, pages 1720 - 1731, XP055365253, ISSN: 0300-922X, DOI: 10.1039/P19730001720
  • AVALOS M ET AL: "A one-pot domino reaction in constructing isoorotate bases and their nucleosides", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 47, no. 12, 20 March 2006 (2006-03-20), pages 1989 - 1992, XP025003753, ISSN: 0040-4039, [retrieved on 20060320], DOI: 10.1016/J.TETLET.2006.01.057
  • DEMETRIOS C. AGATHOCLEOUS ET AL: "Purines, pyrimidines and imidazoles. Part 67. Some N-substituted o-(2-hydroxyethyl)benzyl-purines, -pyrimidines and -imidazoles as aromatic acylonucleoside analogues", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, vol. 1, no. 21, 7 November 1993 (1993-11-07), GB, pages 2555 - 2559, XP055365251, ISSN: 0300-922X, DOI: 10.1039/p19930002555
  • JI J-S ET AL: "Reactions of 3,5-dinitro-4-chlorobenzotrifluoride and 3, 5-dinitro-2-chlorobenzotrifluoride with nitrogen-containing nucleophiles", HUAXUE XUEBAO (1981), ZHONGGUO KEXUEYUAN SHANGHAI YOUJI HUAXUE YANJIUSUO, CN, vol. 47, 1 January 1989 (1989-01-01), pages 396 - 399, XP009125743, ISSN: 0567-7351
  • SENDA S ET AL: "PYRIMIDINE DERVATIVES AND RELATED COMPOUNDS XVII. HYDROLYSIS OF 5-CYANOURACIL DERIVATIVES", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 20, no. 7, 1 January 1972 (1972-01-01), pages 1389 - 1398, XP000926464, ISSN: 0009-2363
  • S SENDA, K HIROTA, J NOTANI: "Pyrimidine Derivatives and Related Compounds. XVI. Synthesis of 1,3-Disubstituted 5-Cyanouracil Derivatives and Related Compounds", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 20, no. 7, 1 July 1972 (1972-07-01), pages 1380 - 1388
  • DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 25 February 2003 (2003-02-25), Database accession no. 494766-26-6
  • DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 25 February 2003 (2003-02-25), Database accession no. 494766-26-6
  • DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 24 March 2003 (2003-03-24), Database accession no. 500347-70-6
  • DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1 November 2004 (2004-11-01), Database accession no. 773098-78-5
  • DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1 November 2004 (2004-11-01), Database accession no. 773098-84-3
  • DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1 November 2004 (2004-11-01), Database accession no. 773108-56-8
  • DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 15 June 2001 (2001-06-15), Database accession no. 341505-71-3

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA RS

DOCDB simple family (publication)

DE 102008030091 A1 20091231; DE 102008030091 B4 20110303; EP 2303848 A2 20110406; US 2011166096 A1 20110707; US 9181199 B2 20151110; WO 2009156182 A2 20091230; WO 2009156182 A3 20100311

DOCDB simple family (application)

DE 102008030091 A 20080625; EP 09769031 A 20090625; EP 2009004698 W 20090625; US 200913000900 A 20090625