EP 2304444 A4 20120425 - MODULATORS OF STAT3 SIGNALLING
Title (en)
MODULATORS OF STAT3 SIGNALLING
Title (de)
MODULATOREN DER STAT3-SIGNALISIERUNG
Title (fr)
MODULATEURS DE L'INTERACTION ENTRE STAT3 ET SP1
Publication
Application
Priority
- SG 2009000192 W 20090601
- US 7382008 P 20080619
Abstract (en)
[origin: WO2009154573A1] The invention relates to methods for identifying compounds which modulate the interaction between STAT3 and SP1. A peptide is provided which is able to bind STAT3 and interfere with the interaction of STAT3 and SP1. The invention provides methods for identifying compounds which are capable of binding to the peptide and thus release interference with the interaction between STAT3 and SP1, as well as methods for identifying inhibitors and enhancers of the STAT3 SP1 interaction. Compounds identified by the methods of the invention are useful in the repression or stimulation of appetite in a patient, and thus are useful for the treatment of leptin resistance, obesity and anorexia.
IPC 8 full level
A61K 45/00 (2006.01); A61P 3/04 (2006.01); C07K 14/47 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP US)
A61P 3/04 (2017.12 - EP); C07K 14/4702 (2013.01 - EP US); G01N 33/68 (2013.01 - EP US); G01N 2333/4703 (2013.01 - EP US); G01N 2500/02 (2013.01 - EP US); G01N 2500/04 (2013.01 - EP US); G01N 2800/044 (2013.01 - EP US)
Citation (search report)
- [X] US 6436703 B1 20020820 - TANG Y TOM [US], et al & DATABASE Geneseq [online] 13 February 2002 (2002-02-13), "Novel human diagnostic protein #20857.", XP002671193, retrieved from EBI accession no. GSP:ABG20866 Database accession no. ABG20866
- [Y] WO 9857177 A1 19981217 - REGENERON PHARMA [US]
- [Y] MARTIN G. MYERS ET AL: "Mechanisms of Leptin Action and Leptin Resistance", ANNUAL REVIEW OF PHYSIOLOGY, vol. 70, no. 1, 1 March 2008 (2008-03-01), pages 537 - 556, XP055021399, ISSN: 0066-4278, DOI: 10.1146/annurev.physiol.70.113006.100707
- [A] J. NAKAE ET AL: "Forkhead Transcription Factor FoxO1 in Adipose Tissue Regulates Energy Storage and Expenditure", DIABETES, vol. 57, no. 3, 1 March 2008 (2008-03-01), pages 563 - 576, XP055021487, ISSN: 0012-1797, DOI: 10.2337/db07-0698
- See references of WO 2009154573A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2009154573 A1 20091223; CN 102066945 A 20110518; EP 2304444 A1 20110406; EP 2304444 A4 20120425; US 2011098218 A1 20110428
DOCDB simple family (application)
SG 2009000192 W 20090601; CN 200980123434 A 20090601; EP 09766956 A 20090601; US 99959509 A 20090601