EP 2307015 A2 20110413 - A PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OSTEOPOROSIS COMPRISING BENZAMIDINE DERIVATIVES OR THEIR SALTS, AND ALENDRONIC ACID OR ITS SALT
Title (en)
A PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OSTEOPOROSIS COMPRISING BENZAMIDINE DERIVATIVES OR THEIR SALTS, AND ALENDRONIC ACID OR ITS SALT
Title (de)
PHARMAZEUTISCHE ZUSAMMENSETZUNG ZUR VERHINDERUNG ODER BEHANDLUNG VON OSTEOPOROSE MIT BENZAMIDINDERIVATEN ODER DEREN SALZEN SOWIE MIT ALENDRONSÄURE ODER DEREN SALZEN
Title (fr)
COMPOSITION PHARMACEUTIQUE POUR PRÉVENIR OU TRAITER L'OSTÉOPOROSE À BASE DE DÉRIVÉS DE BENZAMIDINE OU DE SELS DE CEUX-CI, ET D'ACIDE ALENDRONIQUE OU DE SELS DE CELUI-CI
Publication
Application
Priority
- KR 2009004277 W 20090731
- KR 20080075792 A 20080801
Abstract (en)
[origin: WO2010013969A2] The present invention relates to a pharmaceutical composition for preventing and treating osteoporosis, comprising N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, or salts thereof, and alendronic acid or a salt thereof. As a prophylactic or therapeutic composition for osteoporosis, the combination treatment of N-hydroxy-4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}benzamidine, 4-{5-[4-(5-isopropyl-2-methyl-1,3-thiazol-4-yl)phenoxy]pentoxy}-benzamidine, or salts thereof and alendronic acid or a salt thereof exhibits excellent inhibitory effect on osteoclast differentiation, as compared to each individual treatment, thereby being useful for the prevention or treatment of osteoporosis.
IPC 8 full level
A61K 31/426 (2006.01); A61K 31/663 (2006.01); A61P 19/10 (2006.01)
CPC (source: EP KR)
A61K 31/426 (2013.01 - EP KR); A61K 31/663 (2013.01 - EP KR); A61P 19/10 (2017.12 - EP); A61P 43/00 (2017.12 - EP)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Designated extension state (EPC)
AL BA RS
DOCDB simple family (publication)
WO 2010013969 A2 20100204; WO 2010013969 A3 20100527; CA 2732863 A1 20100204; CN 102149380 A 20110810; CN 102149380 B 20121205; EP 2307015 A2 20110413; EP 2307015 A4 20120516; JP 2011529875 A 20111215; KR 20100014173 A 20100210
DOCDB simple family (application)
KR 2009004277 W 20090731; CA 2732863 A 20090731; CN 200980133563 A 20090731; EP 09803174 A 20090731; JP 2011521043 A 20090731; KR 20090070534 A 20090731