EP 2310365 A1 20110420 - METHOD FOR PRODUCING N-PHENYL-N-(4-PIPERIDINYL)AMIDE SALTS
Title (en)
METHOD FOR PRODUCING N-PHENYL-N-(4-PIPERIDINYL)AMIDE SALTS
Title (de)
VERFAHREN ZUR HERSTELLUNG VON N-PHENYL-N-(4-PIPERIDINYL) AMIDSALZEN
Title (fr)
PROCÉDÉ DE FABRICATION DE SELS DE N-PHÉNYL-N-(4-PIPÉRIDINYL)AMIDE
Publication
Application
Priority
EP 2008005418 W 20080703
Abstract (en)
[origin: WO2010000282A1] The invention relates to a method for producing N-phenyl-N-(4-piperidinyl)amide salts, particularly pharmaceutically tolerable addition salts of the compound Remifentanil, in that a compound of the formula (III) is reacted with an acrylic acid alkyl ester of the formula CH2=CH-C(O)-OR: where independently of each other R denotes low-molecular alkyl, preferably (C1-4)alkyl, preferably methyl or ethyl, R1 denotes low-molecular alkyl, preferably (C1-4)alkyl, preferably methyl or ethyl; and HX denotes an inorganic or organic acid, wherein the components are optionally reacted in the presence of a catalyst, preferably at a higher temperature, thereby obtaining the salt of the compound of formula (I).
IPC 8 full level
C07D 211/66 (2006.01)
CPC (source: EP US)
A61P 25/02 (2017.12 - EP); C07D 211/66 (2013.01 - EP US)
Citation (search report)
See references of WO 2010000282A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA MK RS
DOCDB simple family (publication)
WO 2010000282 A1 20100107; EP 2310365 A1 20110420; JP 2011526257 A 20111006; US 2011144346 A1 20110616
DOCDB simple family (application)
EP 2008005418 W 20080703; EP 08773829 A 20080703; JP 2011515118 A 20080703; US 200813002376 A 20080703