EP 2313373 A1 20110427 - HETEROCYCLIC DERIVATIVES THAT ARE USED IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
Title (en)
HETEROCYCLIC DERIVATIVES THAT ARE USED IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
Title (de)
BEI DER BEHANDLUNG VON NEURODEGENERATIVEN KRANKHEITEN VERWENDETE HETEROCYCLISCHE DERIVATE
Title (fr)
DERIVES HETEROCYCLIQUES UTILES DANS LE TRAITEMENT DE MALADIES NEURODEGENERATIVES
Publication
Application
Priority
- EP 2009059285 W 20090720
- FR 0854921 A 20080718
Abstract (en)
[origin: WO2010007179A1] The present invention relates to compounds of Formula (I) below, to their pharmaceutically acceptable salts and to their isomers or mixtures of isomers: HetAr-X-CHR1R2 (I) in which: - HetAr represents a group chosen from: - X represents a linear, saturated or unsaturated, hydrocarbon-based chain comprising from 8 to 22 carbon atoms, optionally interrupted by an -NH- or -NH-CO- group, - R1 represents a hydrogen atom or an -OH, -O(C1-C6)alkyl, -OCO((C1-C6)alkyl), -OSO2((C1-C6)alkyl) or -OSO3H group, and - R2 represents a hydrogen atom or a (C2-C6)alkynyl, (C2-C6)alkenyl or (C3-C6)cycloalkyl group. The present invention also relates to a process for preparing the compounds of Formula (I), and also to the use thereof, especially in the treatment of neurodegenerative diseases.
IPC 8 full level
C07D 215/14 (2006.01); A61K 31/395 (2006.01); A61K 31/495 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); C07D 241/44 (2006.01)
CPC (source: EP US)
A61P 9/10 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/28 (2017.12 - EP); C07D 215/14 (2013.01 - EP US); C07D 241/44 (2013.01 - EP US)
Citation (search report)
See references of WO 2010007179A1
Citation (examination)
- WO 02057238 A1 20020725 - INST RECH DEVELOPPEMENT IRD [FR], et al
- FR 781812 A 19350522 - IG FARBENINDUSTRIE AG
- MOHAMMED A. FAKHFAKH ET AL: "Synthesis and biological evaluation of substituted quinolines: potential treatment of protozoal and retroviral co-infections", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, no. 23, 1 November 2003 (2003-11-01), pages 5013 - 5023, XP055051150, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2003.09.007
- DURET P ET AL: "Preparative separation of quinolines by centrifugal partition chromatography with gradient elution", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V, NL, vol. 1011, no. 1-2, 5 September 2003 (2003-09-05), pages 55 - 65, XP004450619, ISSN: 0021-9673, DOI: 10.1016/S0021-9673(03)01020-3
- HEAL W ET AL: "Library Synthesis and Screening: 2,4-Diphenylthiazoles and 2,4-Diphenyloxazoles as Potential Novel Prion Disease Therapeutics", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 50, 17 February 2007 (2007-02-17), pages 1347 - 1353, XP002477267, ISSN: 0022-2623, [retrieved on 20070217], DOI: 10.1021/JM0612719
- GARINO C ET AL: "BACE-1 inhibitory activities of new substituted phenyl-piperazine coupled to various heterocycles: Chromene, coumarin and quinoline", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 16, no. 7, 1 April 2006 (2006-04-01), pages 1995 - 1999, XP027966383, ISSN: 0960-894X, [retrieved on 20060401]
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Designated extension state (EPC)
AL BA RS
DOCDB simple family (publication)
WO 2010007179 A1 20100121; CA 2730331 A1 20100121; CN 102099338 A 20110615; EP 2313373 A1 20110427; FR 2933976 A1 20100122; FR 2933976 B1 20130426; FR 2933977 A1 20100122; FR 2933977 B1 20130426; JP 2011528335 A 20111117; US 2011118270 A1 20110519; US 8445511 B2 20130521
DOCDB simple family (application)
EP 2009059285 W 20090720; CA 2730331 A 20090720; CN 200980128111 A 20090720; EP 09780818 A 20090720; FR 0854921 A 20080718; FR 0956449 A 20090918; JP 2011517959 A 20090720; US 200913003992 A 20090720