EP 2313405 A1 20110427 - PREPARATION OF MICROBIOLOGICALLY PRODUCED ERGOT ALKALOIDS
Title (en)
PREPARATION OF MICROBIOLOGICALLY PRODUCED ERGOT ALKALOIDS
Title (de)
AUFARBEITUNG VON MIKROBIOLOGISCH HERGESTELLTEN MUTTERKORNALKALOIDEN
Title (fr)
TRAITEMENT D'ALCALOÏDES DE L'ERGOT DE SEIGLE PRODUITS MICROBIOLOGIQUEMENT
Publication
Application
Priority
- EP 2009058034 W 20090626
- EP 08159330 A 20080630
- EP 09772376 A 20090626
Abstract (en)
[origin: EP2141165A1] Method for reconditioning microbiologically produced ergot alkaloids of 7-methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline-9-carboxylic acid (I), comprises extracting the fermentation product containing (I) occurring during the biological production at a pH of 8-14 using an extractant with a solubility in water of 0.2-25 g/100 g water at 20[deg] C, where the amount of extractant is sufficient to form a 2-phase system together with the fermentation product. Independent claims are included for: (1) paspalic acid, preferably paspalic acid crystals having 2-1000, preferably 5-700 ppm of an extractant comprising n-butanol, sec-butyl alcohol or ethyl formate; and (2) lysergic acid, preferably lysergic acid crystals having 2-1000, preferably 5-700 ppm of extractant comprising n-butanol, sec-butyl alcohol or ethyl formate.
IPC 8 full level
C07D 457/04 (2006.01); C12P 17/18 (2006.01)
CPC (source: EP US)
C07D 457/04 (2013.01 - EP US); C12P 17/183 (2013.01 - EP US)
Citation (search report)
See references of WO 2010000676A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA RS
DOCDB simple family (publication)
EP 2141165 A1 20100106; EP 2313405 A1 20110427; US 2011137035 A1 20110609; WO 2010000676 A1 20100107
DOCDB simple family (application)
EP 08159330 A 20080630; EP 09772376 A 20090626; EP 2009058034 W 20090626; US 200913001876 A 20090626