EP 2321406 A1 20110518 - METHOD FOR SELECTING SECONDARY NEUROSPHERE DERIVED FROM INDUCED PLURIPOTENT STEM CELL
Title (en)
METHOD FOR SELECTING SECONDARY NEUROSPHERE DERIVED FROM INDUCED PLURIPOTENT STEM CELL
Title (de)
VERFAHREN ZUR AUSWAHL EINER SEKUNDÄREN NEUROSPHÄRE AUS EINER INDUZIERTEN PLURIPOTENTEN STAMMZELLE
Title (fr)
PROCÉDÉ DE SÉLECTION D'UNE NEUROSPHÈRE SECONDAIRE ISSUE D'UNE CELLULE SOUCHE PLURIPOTENTE INDUITE
Publication
Application
Priority
- JP 2009003755 W 20090805
- US 8636908 P 20080805
Abstract (en)
[origin: WO2010016253A1] In order to provide a therapeutic agent for nerve injury which contains iPS-derived neural stem cells and has low or no risk of side effects, as well as a method for treating a nerve injury using the iPS cells, by efficiently establishing in vivo the iPS-derived neural stem having low or no risk of tumor formation, neurospheres are formed following formation of embryoid bodies from the iPS cells, and a clone whose ratio of cells in which the promoter of Nanog gene is activated is 0.01% or less is selected, and the clone is administered to a patient suffering from the nerve injury.
IPC 8 full level
C12N 5/079 (2010.01); C12Q 1/68 (2006.01); G01N 33/48 (2006.01)
CPC (source: EP US)
C12N 5/0618 (2013.01 - EP US); C12Q 1/6886 (2013.01 - EP US); A61K 35/12 (2013.01 - EP US); C12N 2501/385 (2013.01 - EP US); C12N 2501/60 (2013.01 - EP US); C12N 2506/45 (2013.01 - EP US); C12N 2510/00 (2013.01 - EP US); C12Q 2600/158 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Designated extension state (EPC)
AL BA RS
DOCDB simple family (publication)
WO 2010016253 A1 20100211; EP 2321406 A1 20110518; EP 2321406 A4 20120502; EP 2321406 B1 20141210; JP 2011530273 A 20111222; JP 5671737 B2 20150218; US 2011183350 A1 20110728
DOCDB simple family (application)
JP 2009003755 W 20090805; EP 09804740 A 20090805; JP 2011505277 A 20090805; US 200913057710 A 20090805