EP 2322631 A1 20110518 - Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA synthetase pairs

Title (en)

Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA synthetase pairs

Title (de)

Verfahren und Zusammensetzungen zur Herstellung von orthogonalen TRNA-Aminoacyl-TRNA-Synthetase-Paaren

Title (fr)

Procédés et composition pour la production de paires d'aminoacyl-ARN-T synthétase orthogonales

Publication

EP 2322631 A1 20110518 (EN)

Application

EP 10182672 A 20020419

Priority

EP 02725743 A 20020419
US 28503001 P 20010419
US 35551402 P 20020206

Abstract (en)

The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.

IPC 8 full level

C12N 15/09 (2006.01); C12N 15/67 (2006.01); A61K 38/00 (2006.01); A61K 38/22 (2006.01); A61P 7/00 (2006.01); C07K 14/00 (2006.01); C07K 14/47 (2006.01); C07K 14/505 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/00 (2006.01); C12N 15/11 (2006.01); C12P 13/00 (2006.01); C12P 13/04 (2006.01); C12P 13/22 (2006.01); C12P 19/26 (2006.01); C12P 21/02 (2006.01); C12Q 1/02 (2006.01); C12Q 1/06 (2006.01)

CPC (source: EP US)

A61P 7/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/00 (2013.01 - EP US); C07K 14/505 (2013.01 - EP US); C12N 9/93 (2013.01 - EP US); C12N 15/67 (2013.01 - EP US); C12P 13/00 (2013.01 - EP US); C12P 13/005 (2013.01 - EP US); C12P 13/04 (2013.01 - EP US); C12P 13/22 (2013.01 - EP US); C12P 19/26 (2013.01 - EP US); C12P 21/00 (2013.01 - US); C12P 21/02 (2013.01 - EP US)

Citation (applicant)

US 28503001 P 20010419
US 35551402 P 20020206
US 6238884 B1 20010529 - SHORT JAY M [US], et al
US 5756316 A 19980526 - SCHELLENBERGER VOLKER [US]
US 5783431 A 19980721 - PETERSON TODD C [US], et al
US 5824485 A 19981020 - THOMPSON KATIE A [US], et al
US 5958672 A 19990928 - SHORT JAY M [US]
US 5001065 A 19910319 - LARRICK JAMES W [US], et al
US 4634664 A 19870106 - OESTBERG LARS [AT]
US 4634666 A 19870106 - ENGLEMAN EDGAR G [US], et al
KNOWLES, J.R.: "Tinkering with enzymes: what are we learning?", SCIENCE, vol. 236, no. 4806, 1987, pages 1252 - 1258
ZOLLER, M.J.; SMITH, M.: "Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors", METHODS ENZYMOL, vol. 154, 1983, pages 468 - 500
P. E. DAWSON; S. B. H. KENT, ANNU. REV. BIOCHEM., vol. 69, 2000, pages 923
V. W. CORNISH; D. MENDEL; P. G. SCHULTZ, ANGEW. CHEM. INT. ED. ENGL., vol. 34, 1995, pages 621
C.J. NOREN; S.J. ANTHONY-CAHILL; M.C. GRIFFITH; P.G. SCHULTZ: "A general method for site-specific incorporation of unnatural amino acids into proteins", SCIENCE, vol. 244, 1989, pages 182 - 188
J.D. BAIN; C.G. GLABE; T.A. DIX; A.R. CHAMBERLIN; E.S. DIALA: "Biosynthetic site-specific incorporation of a non-natural amino acid into a polypeptide", J. AM. CHEM. SOC., vol. 111, 1989, pages 8013 - 8014
M. H. RICHMOND, BACTERIOL. REV., vol. 26, 1962, pages 398
D. B. COWIE; G. N. COHEN; E. T. BOLTON; H. DERROBINCHON-SZULMAJST, BIOCHIM. BIOPHYS. ACTA, vol. 34, 1959, pages 39
R. MUNIER; G. N. COHEN, BIOCHIM. BIOPHYS. ACTA, vol. 31, 1959, pages 378
N. BUDISA; C. MINKS; S. ALEFELDER; W. WENGER; F. M. DONG; L. MORODER; R. HUBER, FASEB J, vol. 13, 1999, pages 41
C. MINKS; R. HUBER; L. MORODER; N. BUDISA, ANAL. BIOCHEM., vol. 284, 2000, pages 29
H. DUEWEL; E. DAUB; V. ROBINSON; J. F. HONEK, BIOCHEMISTRY, vol. 36, 1997, pages 3404
Y. TANG; G. GHIRLANDA; W. A. PETKA; T. NAKAJIMA; W. F. DEGRADO; D. A. TIRRELL, ANGEW. CHEM. INT. ED. ENGL., vol. 40, 2001, pages 1494
W. A. HENDRICKSON; J. R. HORTON; D. M. LEMASTER, EMBO J., vol. 9, 1990, pages 1665
J. O. BOLES; K. LEWINSKI; M. KUNKLE; J. D. ODOM; B. DUNLAP; L. LEBIODA; M. HATADA, NAT. STRUCT. BIOL., vol. 1, 1994, pages 283
N. BUDISA; B. STEIPE; P. DEMANGE; C. ECKERSKORN; J. KELLERMANN; R. HUBER, EUR. J. BIOCHEM., vol. 230, 1995, pages 788
N. BUDISA; W. KARNBROCK; S. STEINBACHER; A. HUMM; L. PRADE; T. NEUEFEIND; L. MORODER; R. HUBER, J. MOL. BIOL., vol. 270, 1997, pages 616
J. C. M. VANHEST; D. A. TIRRELL, FEBS LETT., vol. 428, 1998, pages 68
J. C. M. VAN HEST; K. L. KIICK; D. A. TIRRELL, J. AM. CHEM. SOC., vol. 122, 2000, pages 1282
K. L. KIICK; D. A. TIRRELL, TETRAHEDRON, vol. 56, 2000, pages 9487
N. BUDISA; C. MINKS; F. J. MEDRANO; J. LUTZ; R. HUBER; L. MORODER, PROC. NATL. ACAD. SCI. U S A, vol. 95, 1998, pages 455
M. IBBA; P. KAST; H. HENNECKE, BIOCHEMISTRY, vol. 33, 1994, pages 7107
M. IBBA; H. HENNECKE, FEBS LETT., vol. 364, 1995, pages 272
N. SHARMA; R. FURTER; P. KAST; D. A. TIRRELL, FEBS LETT., vol. 467, 2000, pages 37
F. HAMANO-TAKAKU; T. IWAMA; S. SAITO-YANO; K. TAKAKU; Y. MONDEN; M. KITABATAKE; D. SOLL; S. NISHIMURA, J. BIOL. CHEM., vol. 275, 2000, pages 40324
V. DORING; H. D. MOOTZ; L. A. NANGLE; T. L. HENDRICKSON; V. DE CRECY-LAGARD; P. SCHIMMEL; P. MARLIERE, SCIENCE, vol. 292, 2001, pages 501
KENT, S B H: "Constructing proteins by dovetailing unprotected synthetic peptides: backbone-engineered HIV protease", SCIENCE, vol. 221, 1992, pages 225
CHAIKEN, LM.: "Semisynthetic peptides and proteins", CRC CRIT REV BIOCHEM, 1981, pages 255 - 301
OFFORD, R.E.: "Protein engineering by chemical means?", PROTEIN ENIZ, 1987, pages 151 - 157
JACKSON, D.Y.; BURNIER, J.; QUAN, C.; STANLEY, M.; TOM, J.; WELLS, J.A: "A Designed Peptide Ligase for Total Synthesis of Ribonuclease A with Unnatural Catalytic Residues", SCIENCE, 1994, pages 243
COREY, D.R.; SCHULTZ, P.G.: "Generation of a hybrid sequence-specific single-stranded deoxyribonuclease", SCIENCE, 1987, pages 1401 - 1403
KAISER, E.T.; LAWRENCE D.S.; ROKITA, S.E.: "The chemical modification of enzymatic specificity", REV BIOCHEM, 1985, pages 565 - 595
KAISER, E.T.; LAWRENCE, D.S.: "Chemical mutation of enyzme active sites", SCIENCE, 1984, pages 505 - 511
NEET, K.E.; NANCI A; KOSHLAND, D.E.: "Properties of thiol-subtilisin", J BIOL. CHEM, 1968, pages 6392 - 6401
POLGAR, L.B., M.L.: "A new enzyme containing a synthetically formed active site. Thiol-subtilisin", J. AM CHEM SOC, 1966, pages 3153 - 3154
POLLACK, S.J.; NAKAYAMA, G. SCHULTZ, P.G.: "Introduction ofnucleophiles and spectroscopic probes into antibody combining sites", SCIENCE, 1988, pages 1038 - 1040
BRUNNER, J.: "New Photolabeling and crosslinking methods", ANNU. REV BIOCHEM, 1993, pages 483 - 514
KRIEG, U.C.; WALTER, P.; HOHNSON, A.E.: "Photocrosslinking of the signal sequence of nascent preprolactin of the 54-kilodalton polypeptide of the signal recognition particle", PROC. NATL. ACAD. SCI, 1986, pages 8604 - 8608
NOREN, C.J.; ANTHONY-CAHILL; GRIFFITH, M.C.; SCHULTZ, P.G. A: "general method for site-specific incorporation of unnatural amino acids into proteins", SCIENCE, vol. 244, 1989, pages 182 - 188
M.W. NOWAK ET AL., SCIENCE, vol. 268, 1995, pages 439 - 42
BAIN, J.D.; GLABE, C.G.; DIX, T.A; CHAMBERLIN, A.R.; DIALA, E.S.: "Biosynthetic site-specific Incorporation of a non-natural amino acid into a polypeptide", J. AM CHEM SOC, vol. 111, 1989, pages 8013 - 8014
N. BUDISA ET AL., FASEB J., vol. 13, 1999, pages 41 - 51
ELLMAN, J.A.; MENDEL, D.; ANTHONY-CAHILL, S.; NOREN, C.J.; SCHULTZ, P.G.: "Biosynthetic method for introducing unnatural amino acids site-specifically into proteins", METHODS IN ENZ., 1992, pages 301 - 336
MENDEL, D.; CORNISH, V.W.; SCHULTZ, P.G.: "Site-Directed Mutagenesis with an Expanded Genetic Code", ANNU REV BIOPHYS. BIOMOL STRUCT., vol. 24, 1995, pages 435 - 62
SAYERS, J.R.; SCHMIDT, W.; ECKSTEIN, F.: "5', 3' Exonuclease in phosphorothioate-based olignoucleotide-directed mutagensis", NUCLEIC ACIDS RES, 1988, pages 791 - 802
ELLMAN, J.A.; MENDEL, D.; SCHULTZ, P.G: "Site-specific incorporation of novel backbone structures into proteins", SCIENCE, 1992, pages 197 - 200
M. W. NOWAK; P. C. KEARNEY; J. R. SAMPSON; M. E. SAKS; C. G. LABARCA; S. K. SILVERMAN; W. G. ZHONG; J. THORSON; J. N. ABELSON; N., SCIENCE, vol. 268, 1995, pages 439
D. A. DOUGHERTY, CURR. OPIN. CHEM. BIOL., vol. 4, 2000, pages 645
G. TURCATTI; K. NEMETH; M. D. EDGERTON; U. MESETH; F. TALABOT; M. PEITSCH; J. KNOWLES; H. VOGEL; A. CHOLLET, J. BIOL. CHEM., vol. 271, 1996, pages 19991
J. P. GALLIVAN; H. A. LESTER; D. A. DOUGHERTY, CHEM. BIOL., vol. 4, 1997, pages 739
J. C. MILLER; S. K. SILVERMAN; P. M. ENGLAND; D. A. DOUGHERTY; H. A. LESTER, NEURON, vol. 20, 1998, pages 619
P. M. ENGLAND; Y. ZHANG; D. A. DOUGHERTY; H. A. LESTER, CELL, vol. 96, 1999, pages 89
T. LU; A. Y. TING; J. MAINLAND; L. Y. JAN; P. G. SCHULTZ; J. YANG, NAT. NEUROSCI., vol. 4, 2001, pages 239
R. FURTER, PROTEIN SCI., vol. 7, 1998, pages 419
P. BRICK; T. N. BHAT; D. M. BLOW, J. MOL. BIOL., vol. 208, 1988, pages 83 - 98
FRANCISCO, J. A.; CAMPBELL, R.; IVERSON, B. L.; GEORGOIU, G.: "Production and fluorescence-activated cell sorting of Escherichia coli expressing a functional antibody fragment on the external surface", PROC NATL ACAD SCI U S A., vol. 90, 1993, pages 10444 - 8
SAYERS, J.R.; SCHMIDT, W. ECKSTEIN: "F. 5',3' Exonuclease in phosphorothioate-based oligonucleotide-directed mutagenesis", NUCLEIC ACIDS RES, 1988, pages 791 - 802
C. H. MA; W. KUDLICKI; O. W. ODOM; G. KRAMER; B. HARDESTY, BIOCHEMISTRY, vol. 32, 1993, pages 7939
A. K. KOWAL; J. S. OLIVER, NUCL. ACID. RES., vol. 25, 1997, pages 4685
J. CHRISTOPHER ANDERSON ET AL.: "Exploring the Limits of Codon and Anticodon Size", CHEMISTRY AND BIOLOGY, vol. 9, 2002, pages 237 - 244
THOMAS J. MAGLIERY: "Expanding the Genetic Code: Selection of Efficient Suppressors of Four-base Codons and Identification of "Shifty" Four-base Codons with a Library Approach in Escherichia coli", J. MOL. BIOL., vol. 307, 2001, pages 755 - 769
T. HOHSAKA; D. KAJIHARA; Y. ASHIZUKA; H. MURAKAMI; M. SISIDO, J. AM. CHEM. SOC., vol. 121, 1999, pages 34
T. HOHSAKA; Y. ASHIZUKA; H. SASAKI; H. MURAKAMI; M. SISIDO, J. AM. CHEM. SOC., vol. 121, 1999, pages 12194
B. MOORE; B. C. PERSSON; C. C. NELSON; R. F. GESTELAND; J. F. ATKINS, J. MOL. BIOL., vol. 298, 2000, pages 195
HIRAO ET AL.: "An unnatural base pair for incorporating amino acid analogues into protein", NATURE BIOTECHNOLOGY, vol. 20, 2002, pages 177 - 182
C. SWITZER; S. E. MORONEY; S. A. BENNER, J. AM. CHEM. SOC., vol. 111, 1989, pages 8322
J. A. PICCIRILLI; T. KRAUCH; S. E. MORONEY; S. A. BENNER, NATURE, vol. 343, 1990, pages 33
E. T. KOOL, CURR. OPIN. CHEM. BIOL., vol. 4, 2000, pages 602
K. M. GUCKIAN; E. T. KOOL, ANGEW. CHEM. INT. ED. ENGL., vol. 36, 1998, pages 2825
D. L. MCMINN; A. K. OGAWA; Y. Q. WU; J. Q. LIU; P. G. SCHULTZ; F. E. ROMESBERG, J. AM. CHEM. SOC., vol. 121, 1999, pages 11586
A. K. OGAWA; Y. Q. WU; D. L. MCMINN; J. Q. LIU; P. G. SCHULTZ; F. E. ROMESBERG, J. AM. CHEM. SOC., vol. 122, 2000, pages 3274
A. K. OGAWA; Y. Q. WU; M. BERGER; P. G. SCHULTZ; F. E. ROMESBERG, J. AM. CHEM. SOC., vol. 122, 2000, pages 8803
E. J. L. TAE; Y. Q. WU; G. XIA; P. G. SCHULTZ; F. E. ROMESBERG, J. AM. CHEM. SOC., vol. 123, 2001, pages 7439
E. MEGGERS; P. L. HOLLAND; W. B. TOLMAN; F. E. ROMESBERG; P. G. SCHULTZ, J. AM. CHEM. SOC., vol. 122, 2000, pages 10714
"Biochemistry", 1988, FREEMAN AND COMPANY
FESSENDON; FESSENDON: "Organic Chemistry", 1982, WILLARD GRANT PRESS
"Advanced Organic Chemistry by March", 1985, WILEY AND SONS
CAREY; SUNDBERG: "Advanced Organic Chemistry", 1990, PLENUM PRESS
MATSOUKAS ET AL., J. MED. CHEM., vol. 38, 1995, pages 4660 - 4669
KING, F.E.; KIDD, D.A.A.: "A New Synthesis of Glutamine and of y-Dipeptides of Glutamic Acid from Phthylated Intermediates", J. CHEM. SOC., 1949, pages 3315 - 3319
FRIEDMAN, O.M.; CHATTERRJI, R.: "Synthesis of Derivatives of Glutamine as Model Substrates for Anti-Tumor Agents", J. AM. CHEM. SOC., vol. 81, 1959, pages 3750 - 3752
CRAIG, J.C. ET AL.: "Absolute Configuration of the Enantiomers of 7-Chloro-4 [[4-(diethylamino)-1-methylbutyl]amino]quinoline (Chloroquine)", J. ORG. CHEM., vol. 53, 1988, pages 1167 - 1170
AZOULAY, M.; VILMONT, M.; FRAPPIER, F.: "Glutamine analogues as Potential Antimalarials", EUR. J. MED. CHEM., vol. 26, 1991, pages 201 - 5
KOSKINEN, A.M.P.; RAPOPORT, H.: "Synthesis of 4-Substituted Prolines as Conformationally Constrained Amino Acid Analogues", J. ORG. CHEM., vol. 54, 1989, pages 1859 - 1866
CHRISTIE, B.D.; RAPOPORT, H.: "Synthesis of Optically Pure Pipecolates from L-Asparagine. Application to the Total Synthesis of (+)-Apovincamine through Amino Acid Decarbonylation and Iminium Ion Cyclization", J. ORG. CHEM., 1985, pages 1859 - 1866
BARTON, D.H.R.; HERVE, Y.; POTIER, P.; THIERRY, J.: "Synthesis of Novel a-Amino-Acids and Derivatives Using Radical Chemistry: Synthesis of L- and D-a-Amino-Adipic Acids, L-a-aminopimelic Acid and Appropriate Unsaturated Derivatives", TETRAHEDRON LETT., vol. 43, 1987, pages 4297 - 4308
SUBASINGHE, N.; SCHULTE, M.; ROON, R.J.; KOERNER, J.F.; JOHNSON, R.L.: "Quisqualic acid analogues: synthesis of beta-heterocyclic 2-aminopropanoic acid derivatives and their activity at a novel quisqualate-sensitized site", J. MED. CHEM., vol. 35, 1992, pages 4602 - 7
LIU, D.R.; SCHULTZ, P.G.: "Progress toward the evolution of an organism with an expanded genetic code", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OFAMERICA, vol. 96, 1999, pages 4780 - 4785
NICKITENKO, A.; TRAKHANOV, S.; QUIOCHO, S.: "A structure of DppA, a periplasmic depeptide transport/chemosensory receptor", BIOCHEMISTRY, vol. 34, 1995, pages 16585 - 16595
DUNTEN, P.; MOWBRAY, S.L.: "Crystal structure of the dipeptide binding protein from Escherichia coli involved in active transport and chemotaxis", PROTEIN SCIENCE, vol. 4, 1995, pages 2327 - 34
STEMMER: "Rapid evolution of a protein in vitro by DNA shuffling", NATURE, vol. 370, no. 4, 1994, pages 389 - 391
STEMMER: "DNA shuffling by random fragmentation and reassembly: In vitro recombination for molecular evolution", PROC. NATL. ACAD. SCI. USA., vol. 91, 1994, pages 10747 - 10751
"Fundamental Immunology", 1999, RAVEN PRESS
"Antibody Engineering", 1995, FREEMAN AND COMPANY
MCCAFFERTY ET AL.: "Antibody Engineering, A Practical Approach IRL at Oxford Press", 1996, MCCAFFERTY
PAUL: "Antibody Engineering Protocols Humana Press", 1995
COLIGAN: "Current Protocols in Immunology", 1991, WILEY/GREENE
HARLOW; LANE: "Antibodies: A Laboratory Manual", 1989, COLD SPRING HARBOR PRESS
"Basic and Clinical Immunology", LANGE MEDICAL PUBLICATIONS
GODING: "Monoclonal Antibodies: Principles and Practice", 1986, ACADEMIC PRESS
KOHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
WINTER ET AL.: "Making Antibodies by Phage Display Technology", ANNU. REV. IMMUNOL., vol. 12, 1994, pages 433 - 55
GRIFFITHS; DUNCAN: "Strategies for selection of antibodies by phage display", CURR OPIN BIOTECHNOL, vol. 9, 1998, pages 102 - 8
HOOGENBOOM ET AL.: "Antibody phage display technology and its applications", IMMUNOTECHNOLOGY, vol. 4, 1998, pages 1 - 20
GRAM ET AL.: "in vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library", PNAS, vol. 89, 1992, pages 3576 - 3580
HUSE ET AL., SCIENCE, vol. 246, 1989, pages 1275 - 1281
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BALINT; LARRICK: "Antibody Engineering by Parsimonious Mutagenesis", GENE, vol. 137, 1993, pages 109 - 118
STEMMER ET AL.: "Selection of an Active Single Chain Fv Antibody From a Protein Linker Library Prepared by Enzymatic Inverse PCR", BIOTECHNIQUES, vol. 14, no. 2, 1993, pages 256 - 65
CRAMERI ET AL.: "Construction and evolution of antibody-phage libraries by DNA shuffling", NATURE MEDICINE, vol. 2, 1996, pages 100 - 103
CRAMERI; STEMMER: "Combinatorial multiple cassette mutagenesis creates all the permutations of mutant and wildtype cassettes", BIOTECHNIQUES, vol. 18, 1995, pages 194 - 195
MARKS ET AL.: "By- Passing Immunization: Building High Affinity Human Antibodies by Chain Shuffling", BIOTECHNIQUES, vol. 10, 1992, pages 779 - 782
"BMA", BIOMEDICALS LTD (U.K.), BIO.SYNTHESIS, INC.
OSTBERG ET AL., HYBRIDOMA, vol. 2, 1983, pages 361 - 367
WITTRUP: "Phage on display", TIBTECH, vol. 17, 1999, pages 423 - 424
RUSCH ET AL.: "NR-LU-10 monoclonal antibody scanning. A helpful new adjunct to computed tomography in evaluating non-small-cell lung cancer.", J THORAC CARDIOVASC SURG, vol. 106, 1993, pages 200 - 4
SCOTT: "Rituximab: a new therapeutic monoclonal antibody for non-Hodgkin's lymphoma", CANCER PRACT, vol. 6, 1998, pages 195 - 7
BASELGA ET AL.: "Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts [published erratum appears", CANCER RES, vol. 59, no. 8, 1998, pages 2020
CANCER RES, vol. 58, pages 2825 - 31
DEB ET AL.: "Treatment of hormone-refractory prostate cancer with 90Y-CYT-356 monoclonal antibody", CLIN CANCER RES, vol. 2, 1996, pages 1289 - 97
WOLFE ET AL.: "Antibody-directed enzyme prodrug therapy with the T268G mutant of human carboxypeptidase Al: in vitro and in vivo studies with prodrugs of methotrexate and the thymidylate synthase inhibitors GW 1031 and GW1843", BIOCONJUG CHEM, vol. 10, 1999, pages 38 - 48
STRATE ET AL.: "Orthoclone OKT3 as first-line therapy in acute renal allograft rejection", TRANSPLANT PROC, vol. 22, 1990, pages 219 - 20
XIE ET AL.: "Direct demonstration of MuSK involvement in acetylcholine receptor clustering through identification of agonist ScFv", NAT. BIOTECHNOL., vol. 15, 1997, pages 768 - 71
WENTWORTH; JANDA: "Catalytic antibodies", CURR OPIN CHEM BIOL, vol. 2, 1998, pages 138 - 44
METS ET AL.: "A catalytic antibody against cocaine prevents cocaine's reinforcing and toxic effects in rats", PROC NATL ACAD SCI U S A, vol. 95, 1998, pages 10176 - 81
R. SCOPES: "Protein Purification", 1982, SPRINGER-VERLAG
DEUTSCHER: "Guide to Protein Purification", vol. 182, 1990, ACADEMIC PRESS, INC., article "Methods in Enzymology"
SANDANA: "Bioseparation of Proteins", 1997, ACADEMIC PRESS, INC.
BOLLAG ET AL.: "Protein Methods", 1996, WILEY-LISS
WALKER: "The Protein Protocols Handbook", 1996, HUMANA PRESS
HARRIS; ANGAL: "Protein Purification Applications: A Practical Approach", 1990, IRL PRESS
HARRIS; ANGAL: "Protein Purification Methods: A Practical Approach", IRL PRESS
SCOPES: "Protein Purification: Principles and Practice", 1993, SPRINGER VERLAG
JANSON; RYDEN: "Protein Purification: Principles, High Resolution Methods and Applications", 1998, WILEY-VCH
WALKER: "Protein Protocols on CD-ROM", 1998, HUMANA PRESS
DEBINSKI ET AL., J. BIOL. CHEM., vol. 268, 1993, pages 14065 - 14070
KREITMAN; PASTAN, BIOCONJUG. CHEM., vol. 4, 1993, pages 581 - 585
BUCHNER ET AL., ANAL. BIOCHEM., vol. 205, 1992, pages 263 - 270
TIJSSEN: "Overview of principles of hybridization and the strategy of nucleic acid probe assays", 1993, ELSEVIER, article "Laboratory Techniques in Biochemistry and Molecular Biology--Hybridization with Nucleic Acid Probes part I"
HAMES; HIGGINS: "Gene Probes 1", 1995, IRL PRESS
HAMES; HIGGINS: "Gene Probes", 1995, IRL PRESS
SMITH; WATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
NEEDLEMAN; WUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443
PEARSON; LIPMAN, PROC. NAT'L. ACAD. SCI. USA, vol. 85, 1988, pages 2444
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
HENIKOFF; HENIKOFF, PROC. NATL. ACAD. SCI. USA, vol. 89, 1989, pages 10915
KARLIN; ALTSCHUL, PROC. NAT'L. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5787
HARLOW; LANE: "Antibodies, A Laboratory Manual", 1988, COLD SPRING HARBOR PUBLICATIONS
BERGER; KIMMEL: "Guide to Molecular Cloning Techniques, Methods in Enzymology", vol. 152, ACADEMIC PRESS, INC.
SAMBROOK ET AL.: "Molecular Cloning - A Laboratory Manual", vol. 1-3, 1989, COLD SPRING HARBOR LABORATORY
"Current Protocols in Molecular Biology", 1999, GREENE PUBLISHING ASSOCIATES, INC. AND JOHN WILEY & SONS, INC.
LING ET AL.: "Approaches to DNA mutagenesis: an overview", ANAL BIOCHEM, vol. 254, no. 2, 1997, pages 157 - 178
DALE ET AL.: "Oligonucleotide-directed random mutagenesis using the phosphorothioate method", METHODS MOL. BIOL., vol. 57, 1996, pages 369 - 374
SMITH: "In vitro mutagenesis", ANN. REV. GENET., vol. 19, 1985, pages 423 - 462
BOTSTEIN; SHORTLE: "Strategies and applications of in vitro mutagenesis", SCIENCE, vol. 229, 1985, pages 1193 - 1201
CARTER: "Site-directed mutagenesis", BIOCHEM. J., vol. 237, 1986, pages 1 - 7
KUNKEL: "Nucleic Acids & Molecular Biology", 1987, SPRINGER VERLAG, article "The efficiency of oligonucleotide directed mutagenesis"
KUNKEL: "Rapid and efficient site-specific mutagenesis without phenotypic selection", PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488 - 492
KUNKEL ET AL.: "Rapid and efficient site-specific mutagenesis without phenotypic selection", METHODS IN ENZYMOL., vol. 154, 1987, pages 367 - 382
BASS ET AL.: "Mutant Trp repressors with new DNA-binding specificities", SCIENCE, vol. 242, 1988, pages 240 - 245
METHODS IN ENZYMOL., vol. 100, 1983, pages 468 - 500
METHODS IN ENZYMOL., vol. 154, 1987, pages 329 - 350
ZOLLER; SMITH: "Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any DNA fragment", NUCLEIC ACIDS RES., vol. 10, 1982, pages 6487 - 6500
ZOLLER; SMITH: "Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors", METHODS IN ENZYMOL., vol. 100, 1983, pages 468 - 500
ZOLLER; SMITH: "Oligonucleotide-directed mutagenesis: a simple method using two oligonucleotide primers and a single-stranded DNA template", METHODS IN ENZYMOL., vol. 154, 1987, pages 329 - 350
TAYLOR ET AL.: "The use ofphosphorothioate-modified DNA in restriction enzyme reactions to prepare nicked DNA", NUCL. ACIDS RES., vol. 13, 1985, pages 8749 - 8764
TAYLOR ET AL.: "The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA", NUCL. ACIDS RES., vol. 13, 1985, pages 8765 - 8787
NAKAMAYE; ECKSTEIN: "Inhibition of restriction endonuclease Nci I cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis", NUCL. ACIDS RES., vol. 14, 1986, pages 9679 - 9698
SAYERS ET AL.: "Y-T Exonucleases in phosphorothioate-based oligonucleotide-directed mutagenesis", NUCL. ACIDS RES., vol. 16, 1988, pages 791 - 802
SAYERS ET AL.: "Strand specific cleavage of phosphorothioate-containing DNA by reaction with restriction endonucleases in the presence of ethidium bromide", NUCL. ACIDS RES., vol. 16, 1988, pages 803 - 814
KRAMER ET AL.: "The gapped duplex DNA approach to oligonucleotide-directed mutation construction", NUCL. ACIDS RES., vol. 12, 1984, pages 9441 - 9456
KRAMER; FRITZ: "Oligonucleotide-directed construction of mutations via gapped duplex DNA", METHODS IN ENZYMOL., vol. 154, 1987, pages 350 - 367
KRAMER ET AL.: "Improved enzymatic in vitro reactions in the gapped duplex DNA approach to oligonucleotide-directed construction of mutations", NUCL. ACIDS RES., vol. 16, 1988, pages 7207
FRITZ ET AL.: "Oligonucleotide-directed construction of mutations: a gapped duplex DNA procedure without enzymatic reactions in vitro", NUCL. ACIDS RES., vol. 16, 1988, pages 6987 - 6999
KRAMER ET AL.: "Point Mismatch Repair", CELL, vol. 38, 1984, pages 879 - 887
CARTER ET AL.: "Improved oligonucleotide site-directed mutagenesis using M13 vectors", NUCL. ACIDS RES., vol. 13, 1985, pages 4431 - 4443
CARTER: "Improved oligonucleotide-directed mutagenesis using M13 vectors", METHODS IN ENZYMOL., vol. 154, 1987, pages 382 - 403
EGHTEDARZADEH; HENIKOFF: "Use of oligonucleotides to generate large deletions", NUCL. ACIDS RES., vol. 14, 1986, pages 5115
WELLS ET AL.: "Importance of hydrogen-bond formation in stabilizing the transition state of subtilisin", PHIL. TRANS. R. SOC. LOND. A, vol. 317, 1986, pages 415 - 423
NAMBIAR ET AL.: "Total synthesis and cloning of a gene coding for the ribonuclease S protein", SCIENCE, vol. 223, 1984, pages 1299 - 1301
SAKAMAR; KHORANA: "Total synthesis and expression of a gene for the a-subunit of bovine rod outer segment guanine nucleotide-binding protein (transducin)", NUCL. ACIDS RES., vol. 14, 1988, pages 6361 - 6372
WELLS ET AL.: "Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites", GENE, vol. 34, 1985, pages 315 - 323
GRUNDSTRBM ET AL.: "Oligonucleotide-directed mutagenesis by microscale 'shot-gun' gene synthesis", NUCL. ACIDS RES., vol. 13, 1985, pages 3305 - 3316
MANDECKI: "Oligonucleotide-directed double-strand break repair in plasmids of Escherichia coli: a method for site-specific mutagenesis", PROC. NATL. ACAD. SCI. USA, vol. 83, 1986, pages 7177 - 7181
ARNOLD: "Protein engineering for unusual environments", CURRENT OPINION IN BIOTECHNOLOGY, vol. 4, 1993, pages 450 - 455
SIEBER ET AL., NATURE BIOTECHNOLOGY, vol. 19, 2001, pages 456 - 460
W. P. C. STEMMER, NATURE, vol. 370, 1994, pages 389 - 91
I. A. LORIMER; I. PASTAN, NUCLEIC ACIDS RES., vol. 23, 1995, pages 3067 - 8
METHODS IN ENZYMOLOGY, vol. 154
FROM ET AL., PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 5824
KLEIN ET AL., NATURE, vol. 327, 1987, pages 70 - 73
GILIMAN; SMITH, GENE, vol. 8, 1979, pages 81
ROBERTS ET AL., NATURE, vol. 328, 1987, pages 731
SCHNEIDER, B. ET AL., PROTEIN EXPR. PURIF., vol. 6435, 1995, pages 10
"The ATCC Catalogue of Bacteria and Bacteriophage", 1992, ATCC
WATSON ET AL.: "Recombinant DNA", 1992, SCIENTIFIC AMERICAN BOOKS
FRESHNEY: "Culture of Animal Cells, a Manual of Basic Technique", 1994, WILEY- LISS
PAYNE ET AL.: "Plant Cell and Tissue Culture in Liquid Systems", 1992, JOHN WILEY & SONS, INC.
"Fundamental Methods", 1995, SPRINGER LAB MANUAL, SPRINGER-VERLAG, article "Plant Cell, Tissue and Organ Culture"
"The Handbook of Microbiological Media", 1993, CRC PRESS
Y. KWOK; J. T. WONG; CAN. J., BIOCHEM., vol. 58, 1980, pages 213 - 8
B. A. STEER; P. SCHIMMEL, J. BIOL. CHEM., vol. 274, 1999, pages 35601 - 6
H. JAKUBOWSKI; E. GOLDMAN, MICROBIOL. REV., vol. 56, 1992, pages 412 - 29
L. WANG; T. J. MAGLIERY; D. R. LIU; P. G. SCHULTZ, J. AM. CHEM. SOC., vol. 122, 2000, pages 5010 - 1
M. PASTRNAK; T. J. MAGLIERY; P. G. SCHULTZ, HELVETICA CHIMICA ACTA., vol. 83, 2000, pages 2277 - 86
I. A. LORIMER; I. PASTAN, NUCLEIC ACIDS RES., vol. 23, 1995, pages 3067 - 8
G. D. P. GRAY; H. W. DUCKWORTH; A. R. FERSHT, FEBS, vol. 318, 1993, pages 167 - 71
WANG, L.; SCHULTZ, P. G., CHEM. BIOL., vol. 8, 2001, pages 883 - 890
STEER, B. A; SCHIMMEL, P., J. BIOL. CHEM., vol. 274, 1999, pages 35601 - 35606
WANG, L.; MAGLIERY, T. J.; LIU, D. R.; SCHULTZ, P. G., J. AM. CHEM. SOC., vol. 122, 2000, pages 5010 - 5011
BRICK, P.; BHAT, T. N.; BLOW, D. M., J. MOL. BIOL., vol. 208, 1989, pages 83 - 98
CRAMERI, A.; WHITEHORN, E.A.; TATE, E.; STEMMER, W.P., NATURE BIOTECHNOL., vol. 14, 1996, pages 315 - 319
LORINCZ, M.; ROEDERER, M.; DIWU, Z.; HERZENBERG, L.A.; NOLAN, G.P., CYTOMETRY, vol. 24, 1996, pages 321 - 329
ZLOKARNIK, G.; NEGULESCU, P.A.; KNAPP, T.E.; MERE, L.; BURRES, N.; FENG, L.; WHITNEY, M.; ROEMER, K.; TSIEN, R.Y., SCIENCE, vol. 279, 1998, pages 84 - 88
JERUZALMI, D.; STEITZ, T.A., EMBO J., vol. 17, 1998, pages 4101 - 4113
WANG, L; BROCK, A.; HERBERICH, B.; SCHULTZ, P.G., SCIENCE, vol. 292, 2001, pages 498 - 500
WANG, L.; BROCK, A.; SCHULTZ, P.G., J. AM. CHEM. SOC., vol. 124, 2002, pages 1836 - 1837
HEST, J.C.M.V.; K.L. KIICK; D.A. TIRRELL, J. AM. CHEM. SOC., vol. 122, 2000, pages 1282
HAMANO-TAKAKU, F. ET AL., J.BIOL. CHEM., vol. 275, 2000, pages 40324
BUDISA, N. ET AL., FASEB J., vol. 13, 1999, pages 41 - 51
WANG, L. ET AL., SCIENCE, vol. 292, 2001, pages 498 - 500
WANG, L.; P.G. SCHULTZ, CHEM. COMM., 2002, pages L-10
YANAI, K.: "Streptomyces venezuelae genes papA, papB, papC, in PCT Int. Appl", 2001, MEIJI SEIKA KAISHA LTD., pages: 1 - 83
BLANC, V. ET AL.: "Identification and analysis of genes from Streptomyces pristinaespiralis encoding enzymes involved in the biosynthesis of the 4-dimethylamino-L-phenylalanine precursor ofpristinamycin 1", MOLECULAR MICROBIOLOGY, vol. 23, no. 2, 1997, pages 191 - 202
WANG, L. ET AL.: "A new functional suppressor tRNA/aminoacyl-tRNA synthetase pair for the in vivo incorporation of unnatural amino acids into proteins", J. AM. CHEM. SOC., vol. 122, 2000, pages 5010 - 5011
WANG, L.; P.G. SCHULTZ, CHEM. AND BIOL., vol. 8, 2001, pages 883
WANG, L. ET AL.: "Expanding the genetic code of Escherichia coli", SCIENCE, vol. 292, 2001, pages 498 - 500
WANG, L.; P.G. SCHULTZ: "Expanding the Genetic Code", CHEM. COMM., vol. 1, 2002, pages 1 - 10
WANG, L.; A. BROCK; P.G. SCHULTZ: "Adding L-3-(2-naphthyl)alanine to the genetic code of E. coli", J. AM. CHEM. SOC., vol. 124, 2002, pages 1836
SCHULTZ, METHODS AND COMPOSITIONS FOR THE PRODUCTION OF ORTHOGONAL TRNA-TRNA SYNTHETASE PAIRS
WANG, L. ET AL.: "Expanding the genetic code of Escherichia coli.", SCIENCE, vol. 292, 2001, pages 498 - 500
PASTERNAK, M.; T.J. MAGLIERY; P.G. SCHULTZ: "A new orthogonal suppressor tRNA/aminoacyl-tRNA synthetase pair for evolving an organism with an expanded genetic code", HELVETICA CHEMICA ACTA, vol. 83, 2000, pages 2277
B. NILSSON ET AL., PROTEIN ENG., vol. 1, 1987, pages 107 - 113
SHAO, J., TAM, J. J. AM. CHEM. SOC., vol. 117, 1995, pages 3893 - 3899
CORNISH, V. W.; HAHN, K. M.; SCHULTZ, P. G., J. AM. CHEM. SOC., vol. 118, 1996, pages 8150 - 8151
P.BRICK; T.N.BHAT; D.M.BLOW, JOURNAL OF MOLECULAR BIOLOGY, vol. 208, 1989, pages 83
WANG, L.; BROCK, A.; HERBERICH, B.; SCHULTZ, P. G., SCIENCE, vol. 292, 2001, pages 498 - 500
SANTORO SW; SCHULTZ PG., PROC NATL ACAD SCI U S A, vol. 99, no. 7, 2 April 2002 (2002-04-02), pages 4185 - 90
MCTIGUE, M. A.; WILLIAMS, D. R.; TAINER, J. A., JOURNAL OF MOLECULAR BIOLOGY, vol. 246, 1995, pages 21 - 27
LIU, D.R.; SCHULTZ, P.G.: "Progress toward the evolution of an organism with an expanded genetic code", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 96, 1999, pages 4780 - 4785
JUCOVIC, M.; HARTLEY, R.W.: "Protein-protein interaction: a genetic selection for compensating mutations at the barnase-barstar interface", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 93, 1996, pages 2343 - 2347
WEINER, J.H.; FURLONG, C.E.; HEPPEL, L.A.: "A binding protein for L-glutamine and its relation to active transport in E. coli", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 142, 1971, pages 715 - 7
YANAI, K.: "PCT Int. Appl.", 2001, MEIJI SEIKA KAISHA LTD., article "Streptomyces venezuelae genes papA , papB, papC", pages: 1 - 83
F.C. NEIDHARDT: "Escherichia coli and Salmonella", vol. 1, 1996, ASM PRESS
HE, J ET AL., MICROBIOLOGY, vol. 147, 2001, pages 2817 - 2829
MOSS, R.E., METHODS IN ENZYMOLOGY, vol. 262, 1995, pages 497 - 499
MIMURA, H.; S. NAGAT; T. MATSUMOTO, BIOSCI. BIOTECH. BIOCHEM., vol. 58, no. 10, 1994, pages 1873 - 1874
JANG-YOUNG LEE; LUYING XUN, BIOTECHNOLOGY LETTERS, vol. 20, 1998, pages 479 - 482
SUMMERS, W.C., J. HIST. BIOL., vol. 24, 1991, pages 171 - 190
MILLER, J.H.: "A short course in bacterial genetics", 1992, COLD SPRING HARBOR LABORITORY PRESS
BRONSON, J.J.; J.F. BARRETT, CURR. MED. CHEMISTRY, vol. 8, 2001, pages 1775 - 1793
BEARDEN, D.T.; L.H. DANZIGER, PHARMACOTHERAPY, vol. 21, no. 10, 2001, pages 224S - 232S
MATTHEWS, D.A. ET AL., J. MOL. BIOL., vol. 2144, no. 4, 1990, pages 937 - 948
KNOX, M.R.; J.E. HARRIS, ARCH. MICROBIOL., vol. 149, no. 6, 1988, pages 557 - 60
MCGOWAN, C.C.; T.L. COVER; M.J. BLASER, GASTEROENTEROLOGY, vol. 107, no. 5, 1994, pages 1573 - 8
CLARK, D.P.; J.E. CRONAN: "Escheria coli and Salmonella cellular and molecular biology", vol. 1, 1996, ASM PRESS, article "Two carbon compounds and fatty acids as carbon sources"
SLONCZEWSKI, J.L.; J.W. FOSTER: "Escheria coli and Salmonella cellular and molecular biology", vol. 1, 1996, ASM PRESS, article "pH- regulated genes and survival at extreme pH"
RITZ, D.; J. BECKWITH, ANNU. REV.MICROBIOL., vol. 55, 2001, pages 21 - 48

Citation (search report)

[I] PASTRNAK M ET AL: "A new Orthogonal Suppressor tRNA/Aminoacyl-tRNA Synthetase Pair for evolving an Organism with an Expanded Genetic Code", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA. BASEL, CH, vol. 83, 1 January 2000 (2000-01-01), pages 2277 - 2286, XP002995400, ISSN: 0018-019X
[I] WANG L ET AL: "A new functional suppressor tRNA/aminoacyl-tRNA synthetase apir for in vivo incorporation of unnatural amino acids into proteins", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC. US, vol. 122, 4 May 2000 (2000-05-04), pages 5010 - 5011, XP002390005, ISSN: 0002-7863
[I] LIU D R ET AL: "Engineering a tRNA and aminoacyl-tRNA synthetase for the site-specific incorporation of unnatural amino acids into proteins in vivo", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 94, 1 September 1997 (1997-09-01), pages 10092 - 10097, XP002954766, ISSN: 0027-8424
[I] LIU D R ET AL: "Characterization of an 'orthogonal' suppressor tRNA derived from E.coli tRNA2Gln", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 4, no. 9, 1 September 1997 (1997-09-01), pages 685 - 691, XP002974766, ISSN: 1074-5521, DOI: 10.1016/S1074-5521(97)90224-6
[A] LIU D R ET AL: "PROGRESS TOWARD THE EVOLUTION OF AN ORGANISM WITH AN EXPANDED GENETIC CODE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US, vol. 96, 1 April 1999 (1999-04-01), pages 4780 - 4785, XP001040352, ISSN: 0027-8424, DOI: 10.1073/PNAS.96.9.4780
[IP] WANG L ET AL: "A general approach for the generation of orthogonal tRNAs", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 8, 27 July 2001 (2001-07-27), pages 883 - 890, XP002974765, ISSN: 1074-5521
[IP] LEI WANG ET AL: "Expanding the genetic code of Escherichia coli", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, vol. 292, 20 April 2001 (2001-04-20), pages 498 - 500, XP002904367, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.1060077

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