EP 2330105 A1 20110608 - Heteroaryl urea derivatives useful for inhibiting CHK1

Title (en)

Heteroaryl urea derivatives useful for inhibiting CHK1

Title (de)

Heteroaryl substituierte Harnstoffe als CHK1-Inhibitoren

Title (fr)

Dérivés d'uree d'heteroaryle utilises pour inhiber CHK1

Publication

EP 2330105 A1 20110608 (EN)

Application

EP 10189889 A 20060329

Priority

EP 06748900 A 20060329
US 66602605 P 20050329

Abstract (en)

Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division, also are disclosed.

IPC 8 full level

C07D 403/12 (2006.01); A61K 31/497 (2006.01); A61K 31/5355 (2006.01); A61K 31/541 (2006.01); A61P 35/00 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01)

CPC (source: EP KR US)

A61K 31/497 (2013.01 - KR); A61P 17/02 (2017.12 - EP); A61P 17/06 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 35/04 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 401/12 (2013.01 - KR); C07D 403/12 (2013.01 - EP US); C07D 413/12 (2013.01 - EP KR US); C07D 413/14 (2013.01 - KR); C07D 417/12 (2013.01 - EP US)

Citation (applicant)

US 6218109 B1 20010417 - ELLEDGE STEPHEN J [US], et al
US 8771502 A 20020301
US 58308004 P 20040625
US 58529204 P 20040702
US 60296804 P 20040819
US 2004014765 A1 20040122 - BOYLE ROBERT GEORGE [GB], et al
US 2003199511 A1 20031023 - LI QUN [US], et al
WO 03101444 A1 20031211 - MILLENNIUM PHARM INC [US], et al
WO 03029241 A1 20030410 - SMITHKLINE BEECHAM CORP [US], et al
WO 03028731 A1 20030410 - SMITHKLINE BEECHAM CORP [US], et al
WO 03028724 A1 20030410 - SMITHKLINE BEECHAM CORP [US], et al
WO 0157206 A2 20010809 - RIBOZYME PHARM INC [US], et al
US 6211164 B1 20010403 - LUO YAN [US], et al
WO 0016781 A1 20000330 - SMITHKLINE BEECHAM CORP [US], et al
WO 03037886 A2 20030508 - PHARMACIA CORP [US], et al
WO 03029242 A1 20030410 - SMITHKLINE BEECHAM CORP [US], et al
WO 03004488 A1 20030116 - CHIRON CORP [US], et al
US 2004092535 A1 20040513 - BARSANTI PAUL A [US], et al
WO 2004018419 A2 20040304 - CHIRON CORP [US], et al
WO 0216326 A1 20020228 - AGOURON PHARMA [US]
US 6495586 B2 20021217 - JACOBS ROBERT S [US], et al
WO 0153274 A1 20010726 - AGOURON PHARMA [US]
WO 0153268 A2 20010726 - AGOURON PHARMA [US]
WO 02070515 A2 20020912 - PHARMACIA ITALIA SPA [IT], et al
WO 9917769 A1 19990415 - BASF AG [DE], et al
WO 9853050 A2 19981126 - CHILDRENS MEDICAL CENTER [US], et al
WO 03051838 A2 20030626 - ABBOTT LAB [US]
WO 2004063198 A1 20040729 - PFIZER [US], et al
WO 2004048343 A1 20040610 - SCHERING AG [DE]
WO 2004014876 A1 20040219 - ABBOTT LAB [US]
WO 03091255 A1 20031106 - WARNER LAMBERT CO [US], et al
US 4293552 A 19811006 - MIESEL JOHN L
US 2004030806 W 20040917
US 50392503 P 20030917
WO 9911795 A1 19990311 - ICOS CORP [US], et al
US 2002016521 A1 20020207 - CULVER DAVID A [US], et al
US 9500912 W 19950123
US 2003069284 A1 20030410 - KEEGAN KATHLEEN S [US], et al
HARTWELL ET AL., SCIENCE, vol. 246, 1989, pages 629 - 634
WEINERT ET AL., GENES DEV., vol. 8, 1994, pages 652
SHI ET AL., CANCER RES., vol. 61, 2001, pages 1065 - 1072
CARR, SCIENCE, vol. 271, 1996, pages 314 - 315
ALEN ET AL., GENES DEV., vol. 8, 1994, pages 2416 - 2488
HARTWELL ET AL., SCIENCE, vol. 266, 1994, pages 1821 - 28
WEINBERG, CELL, vol. 81, 1995, pages 323 - 330
LEVINE, CELL, vol. 88, 1997, pages 3234 - 331
BUNZ ET AL., SCIENCE, vol. 282, 1998, pages 1497 - 501
SANCHEZ ET AL., SCIENCE, vol. 277, 1997, pages 1497 - 1501
LUI ET AL., GENES DEV., vol. 14, 2000, pages 1448 - 1459
CHEN ET AL., ONCOGENE, vol. 18, 1999, pages 249 - 256
O'CONNELL ET AL., EMBO J., vol. 16, 1997, pages 545 - 554
SANCHEZ ET AL., SCIENCE, vol. 286, 1999, pages 1166 - 1171
FEIJOO ET AL., J. CELL BIOL., vol. 154, 2001, pages 913 - 923
ZHAO ET AL., PNAS U.S.A, vol. 99, 2002, pages 14795 - 800
XIAO ET AL., J BIOL CHEM., vol. 278, no. 24, 2003, pages 21767 - 21773
SORENSEN ET AL., CANCER CELL, vol. 3, no. 3, 2003, pages 247 - 58
FERNERY ET AL., SCIENCE, vol. 277, 1997, pages 1495 - 7
MATSUOKA ET AL., SCIENCE, vol. 282, 1998, pages 1893 - 1897
BLASINA ET AL., CURR. BIOL., vol. 9, 1999, pages 1 - 10
TENZER ET AL., CURR. MED CHEM. ANTICANCER AGENTS, vol. 3, 2003, pages 35 - 46
HIROSE ET AL., CANCER RES., vol. 61, 2001, pages 5843 - 5849
GRANT ET AL., DRUG RESISTANCE UPDATES, vol. 6, 2003, pages 15 - 26
MACK ET AL., CANCER CHEMOTHER. PHARMACOL., vol. 51, no. 4, 2003, pages 337 - 348
ANDREASSEN ET AL., PROC NATL ACAD SCI U.S.A., vol. 86, 1992, pages 2272 - 2276
BRACEY ET AL., CLIN. CANCER RES., vol. 3, 1997, pages 1371 - 1381
YIN ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 295, 2002, pages 435 - 44
FAN ET AL., CANCER RES., vol. 55, 1995, pages 1649 - 54
SCHULTZ ET AL., J. MED. CHEM., 1999, pages 2909 - 2919
SEDLACEK ET AL., INT J. ONCOL., vol. 9, 1996, pages 1143 - 1168
Z. MA ET AL., TETRAHEDRON: ASYMMETRY, vol. 8, no. 6, 1997, pages 883 - 888
"Design of Prodrugs", 1985, ELSEVIER
R.B. SILVERMAN: "The Organic Chemistry of Drug Design and Drug Action", 1992, ACADEMIC PRESS
K.M. HILLGREN ET AL., MED. RES. REV., vol. 15, 1995, pages 83
BRADLEY ET AL., CLIN. CANCER RES., vol. 7, 2001, pages 3229
AJIRO ET AL., J BIOL CHEM., vol. 271, 1996, pages 13197 - 201
GOTO ET AL., J BIOL CHEM., vol. 274, 1999, pages 25543 - 9
LIU ET AL., GENES DEV., vol. 14, 2000, pages 1448 - 1459
ZHAO ET AL., MOL. CELL BIOL., vol. 21, 2001, pages 4129 - 4139
LOPEZ-GIRONA ET AL., PROC. NATL. ACAD. SCI. U. S. A., vol. 98, 2001, pages 11289 - 11294
GUO ET AL., GENES DEV., vol. 14, 2000, pages 2745 - 2756
GATEI ET AL., J. BIOL. CHEM., vol. 278, 2003, pages 14806 - 14811
NG ET AL., J BIOL CHEM., vol. 279, no. 10, 2004, pages 8808 - 19
WANG ET AL., NATL ACAD SCI U S A., vol. 100, no. 26, 2003, pages 15387 - 92
STOJIC ET AL., GENES DEV., vol. 18, no. 11, 2004, pages 1331 - 44

Citation (search report)

[YD] WO 02070494 A1 20020912 - ICOS CORP [US]
[YD] US 2004014765 A1 20040122 - BOYLE ROBERT GEORGE [GB], et al
[Y] US 2004259885 A1 20041223 - LI GAOQUAN [US], et al

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

Designated extension state (EPC)

AL BA HR MK YU

DOCDB simple family (publication)

WO 2006105262 A1 20061005; AR 056645 A1 20071017; AT E490248 T1 20101215; AU 2006230337 A1 20061005; AU 2006230337 B2 20111027; BR PI0609667 A2 20100420; CA 2602199 A1 20061005; CA 2602199 C 20130910; CN 101151259 A 20080326; CN 101151259 B 20110615; CN 102219784 A 20111019; CR 9395 A 20080331; CY 1111240 T1 20150611; DE 602006018590 D1 20110113; DK 1869020 T3 20110124; EA 011287 B1 20090227; EA 200702094 A1 20080228; EP 1869020 A1 20071226; EP 1869020 B1 20101201; EP 2330105 A1 20110608; ES 2356068 T3 20110404; HK 1119670 A1 20090313; HR P20100678 T1 20110228; IL 185481 A0 20080106; JP 2008535830 A 20080904; JP 2009227682 A 20091008; JP 5117374 B2 20130116; KR 100912998 B1 20090820; KR 20070107178 A 20071106; KR 20090031459 A 20090325; MA 29439 B1 20080502; MX 2007012116 A 20080408; NO 20074944 L 20071024; NZ 561458 A 20110331; PL 1869020 T3 20110531; PT 1869020 E 20101223; RS 51616 B 20110831; SI 1869020 T1 20110228; TN SN07369 A1 20081231; TW 200722090 A 20070616; TW I375559 B 20121101; UA 92164 C2 20101011; US 2009143357 A1 20090604; US 8093244 B2 20120110; ZA 200707715 B 20090930

DOCDB simple family (application)

US 2006011584 W 20060329; AR P060101226 A 20060329; AT 06748900 T 20060329; AU 2006230337 A 20060329; BR PI0609667 A 20060329; CA 2602199 A 20060329; CN 200680010150 A 20060329; CN 201110102211 A 20060329; CR 9395 A 20070926; CY 111100117 T 20110203; DE 602006018590 T 20060329; DK 06748900 T 20060329; EA 200702094 A 20060329; EP 06748900 A 20060329; EP 10189889 A 20060329; ES 06748900 T 20060329; HK 08107066 A 20080625; HR P20100678 T 20101207; IL 18548107 A 20070823; JP 2008504337 A 20060329; JP 2009122107 A 20090520; KR 20077022281 A 20070928; KR 20097002925 A 20090212; MA 30325 A 20071026; MX 2007012116 A 20060329; NO 20074944 A 20071001; NZ 56145806 A 20060329; PL 06748900 T 20060329; PT 06748900 T 20060329; RS P20110053 A 20060329; SI 200630870 T 20060329; TN SN07369 A 20070928; TW 95110859 A 20060329; UA A200710711 A 20060329; US 90841606 A 20060329; ZA 200707715 A 20070907