EP 2331080 A1 20110615 - PHARMACEUTICAL COMPOSITIONS CONFIGURED TO DETER DOSAGE FORM SPLITTING
Title (en)
PHARMACEUTICAL COMPOSITIONS CONFIGURED TO DETER DOSAGE FORM SPLITTING
Title (de)
PHARMAZEUTISCHE ZUSAMMENSETZUNGEN ZUR VERHINDERUNG VON DARREICHUNGSFORMAUFSPALTUNG
Title (fr)
COMPOSITIONS PHARMACEUTIQUES CONFIGURÉES POUR DISSUADER LE FRACTIONNEMENT DES FORMES POSOLOGIQUES
Publication
Application
Priority
- US 2009033919 W 20090212
- US 2008072914 W 20080812
Abstract (en)
[origin: WO2010019279A1] An oral pharmaceutical composition comprising a drug and one or more pharmaceutically acceptable excipients in a monolithic dosage form, wherein the dosage form is configured such that when the dosage form is divided into more than one piece and at least one of the pieces is administered to a subject the Cmax, AUC, and/or rate of drug released after administration is substantially the same or lower and the Tmax is higher than the Cmax, AUC, rate of drug released, and/or Tmax after administration of: (1 ) a comparable composition in intact dosage form of equal drug dosage of the administered at least one piece; (2) a bioequivalent drug composition in an intact dosage form of equal drug dosage to the administered at least one piece; and (3) a divided piece of a bioequivalent drug composition, wherein the divided piece comprises a drug dosage equal to the dosage of the administered piece of the oral composition. Methods of making the same and methods of using the same are also provided.
IPC 8 full level
A61K 9/22 (2006.01); A61K 9/20 (2006.01); A61K 31/485 (2006.01)
CPC (source: EP)
A61K 9/2086 (2013.01)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK TR
Designated extension state (EPC)
AL BA RS
DOCDB simple family (publication)
WO 2010019279 A1 20100218; WO 2010019279 A8 20110317; AU 2009282376 A1 20100218; CA 2734075 A1 20100218; CA 2734075 C 20170418; EP 2331080 A1 20110615; EP 2331080 A4 20121107
DOCDB simple family (application)
US 2009033919 W 20090212; AU 2009282376 A 20090212; CA 2734075 A 20090212; EP 09806994 A 20090212