EP 2332941 A4 20120808 - STABILIZED SOLID DISPERSION OF ADEFOVIR DIPIVOXIL AND PREPARATION METHOD THEREOF
Title (en)
STABILIZED SOLID DISPERSION OF ADEFOVIR DIPIVOXIL AND PREPARATION METHOD THEREOF
Title (de)
STABILISIERTE FESTSTOFFDISPERSION AUS ADEFOVIR-DIPIVOXIL SOWIE VERFAHREN ZU IHRER HERSTELLUNG
Title (fr)
DISPERSION SOLIDE STABILISÉE D ADEFOVIR DIPIVOXIL ET SA MÉTHODE DE PRÉPARATION
Publication
Application
Priority
- KR 2009005271 W 20090916
- KR 20080090869 A 20080917
Abstract (en)
[origin: EP2332941A2] The present invention relates to an amorphous solid dispersion with improved stability comprising 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine as a nucleotide analogue, a pharmaceutical composition comprising the same, and a method for preparing the same.
IPC 8 full level
C07D 473/32 (2006.01)
CPC (source: EP KR US)
A61K 9/10 (2013.01 - KR); A61K 9/146 (2013.01 - EP US); A61P 1/16 (2017.12 - EP); A61P 31/18 (2017.12 - EP); A61P 31/20 (2017.12 - EP); C07D 473/32 (2013.01 - EP KR US)
Citation (search report)
- [XI] CN 100417658 C 20080910 - JIANGSU WUZHONG SUYAO MEDICINE [CN]
- [XI] CN 1879635 A 20061220 - BRIGHT GENE BIO MEDICAL SUZHOU [CN]
- [X] WO 0035460 A2 20000622 - GILEAD SCIENCES INC [US], et al
- [X] WO 9904774 A2 19990204 - GILEAD SCIENCES INC [US], et al
- [X] US 6635278 B1 20031021 - DAHL TERRENCE C [US], et al
- [X] CUNDY K C ET AL: "Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS, NEW YORK, NY, US, vol. 11, no. 6, 1 June 1994 (1994-06-01), pages 839 - 843, XP002083429, ISSN: 0724-8741, DOI: 10.1023/A:1018925723889
- See references of WO 2010032958A2
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
EP 2332941 A2 20110615; EP 2332941 A4 20120808; CN 102149715 A 20110810; CN 104173356 A 20141203; JP 2012502902 A 20120202; KR 100983322 B1 20100920; KR 20100032342 A 20100325; TW 201014866 A 20100416; TW I389915 B 20130321; US 2011201575 A1 20110818; WO 2010032958 A2 20100325; WO 2010032958 A3 20100624
DOCDB simple family (application)
EP 09814774 A 20090916; CN 200980135777 A 20090916; CN 201410342539 A 20090916; JP 2011526818 A 20090916; KR 2009005271 W 20090916; KR 20090087560 A 20090916; TW 98131387 A 20090917; US 200913119154 A 20090916