EP 2340247 A4 20120516 - QUINOLIZIDINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
Title (en)
QUINOLIZIDINONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
Title (de)
POSITIVE ALLOSTERE MODULATOREN DES CHINOLIZIDINON-M1-REZEPTORS
Title (fr)
MODULATEURS ALLOSTÉRIQUES POSITIFS DU RÉCEPTEUR M1 DE LA QUINOLIZIDINONE
Publication
Application
Priority
- US 2009058763 W 20090929
- US 19530208 P 20081006
Abstract (en)
[origin: WO2010042347A1] The present invention is directed to quinolizidinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
IPC 8 full level
A61K 31/4375 (2006.01); A61P 25/28 (2006.01); C07D 455/02 (2006.01)
CPC (source: EP US)
A61P 25/04 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/20 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 455/02 (2013.01 - EP US)
Citation (search report)
- [X] EP 0157346 A2 19851009 - FUJISAWA PHARMACEUTICAL CO [JP]
- [T] S. D. KUDAK ET. AL.: "Quinolizidinone Carboxylic Acids as CNS Penetrant, Selective M1 Allosteric Muscarinic Receptor Modulators.", MEDICINAL CHEMISTRY LETTERS, vol. 1, no. 6, 4 June 2010 (2010-06-04), pages 263 - 267, XP002672501
- See references of WO 2010042347A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2010042347 A1 20100415; AU 2009302703 A1 20100415; CA 2738812 A1 20100415; EP 2340247 A1 20110706; EP 2340247 A4 20120516; EP 2340247 B1 20131204; JP 2012504627 A 20120223; US 2011178122 A1 20110721; US 8278453 B2 20121002
DOCDB simple family (application)
US 2009058763 W 20090929; AU 2009302703 A 20090929; CA 2738812 A 20090929; EP 09819655 A 20090929; JP 2011530138 A 20090929; US 200913121423 A 20090929