EP 2352829 A1 20110810 - TREATING HEPATITIS C VIRUS INFECTION WITH OVER-EXPRESSION OF MICRORNA-196
Title (en)
TREATING HEPATITIS C VIRUS INFECTION WITH OVER-EXPRESSION OF MICRORNA-196
Title (de)
BEHANDLUNG EINER INFEKTION MIT HEPATITIS-C-VIRUS MITTELS ÜBEREXPRESSION VON MICRORNA-196
Title (fr)
TRAITEMENT DE L'INFECTION PAR LE VIRUS DE L'HÉPATITE C AVEC UNE SUREXPRESSION DE MICRO-ARN-196
Publication
Application
Priority
- US 2009059944 W 20091008
- US 10360908 P 20081008
Abstract (en)
[origin: WO2010042683A1] The present invention is directed to methods of treating cells infected with HCV and mammals suffering from HCV infection by transfecting the infected cells with miRNA-196 mimic. miRNA-196 mimic significantly down-regulates Bach1 protein and HCV gene expression, while also up-regulating HMOX1 gene expression. miRNA-196 binds with the 3'-UTR of Bach1 mRNA to reduce the expression of Bach1. As such, miRNA-196 can play an important role in the regulation of HCV replication and HMOX1/Bach1 expression in hepatocytes. The present invention also provides a formulation for the treatment of cells expressing HCV comprising a therapeutically effective amount of miRNA-196 such that Bach1 and HCV gene expression are down- regulated while HMOX1 expression is increased. The formulations are adapted to enable the transfection of miRNA-196 mimic into hepatocytes expressing HCV proteins.
IPC 8 full level
C12N 15/113 (2010.01); A61K 31/713 (2006.01); A61P 31/14 (2006.01)
CPC (source: EP KR)
A61K 31/7105 (2013.01 - KR); A61P 1/16 (2017.12 - EP); A61P 31/14 (2017.12 - EP); C12N 15/113 (2013.01 - EP KR); C12N 2310/141 (2013.01 - EP); C12N 2330/10 (2013.01 - EP)
Citation (search report)
See references of WO 2010042683A1
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2010042683 A1 20100415; AR 073800 A1 20101201; AU 2009302344 A1 20100415; AU 2009302344 A2 20110428; BR PI0914060 A2 20151117; CA 2739948 A1 20100415; CN 102257140 A 20111123; EP 2352829 A1 20110810; JP 2012505233 A 20120301; KR 20110065568 A 20110615; MX 2011003813 A 20110728
DOCDB simple family (application)
US 2009059944 W 20091008; AR P090103885 A 20091008; AU 2009302344 A 20091008; BR PI0914060 A 20091008; CA 2739948 A 20091008; CN 200980145162 A 20091008; EP 09741517 A 20091008; JP 2011531164 A 20091008; KR 20117010438 A 20091008; MX 2011003813 A 20091008