EP 2356123 B1 20121003 - SPIRO-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENES
Title (en)
SPIRO-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENES
Title (de)
SPIRO-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZABENZO[E] AZULENE
Title (fr)
SPIRO-5,6-DIHYDRO-4H-2,3,5,10B-TÉTRAZA-BENZO[E]AZULÈNES
Publication
Application
Priority
- EP 2009064565 W 20091104
- EP 08169028 A 20081113
- EP 09745058 A 20091104
Abstract (en)
[origin: US2010120751A1] The present invention is concerned with spiro-dihydrotetraazabenzoazulenes, i.e. spiro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes of formula I wherein R1, R2, R3, X, Y, Z, m and n are as described herein. The compounds according to the invention act as V1a receptor modulators and are useful as therapeutics acting peripherally and centrally in the conditions of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior.
IPC 8 full level
C07D 487/10 (2006.01); A61K 31/4196 (2006.01); A61K 31/435 (2006.01); A61P 9/00 (2006.01); C07D 491/107 (2006.01); C07D 495/10 (2006.01)
CPC (source: EP KR US)
A61K 31/5517 (2013.01 - KR); A61P 1/16 (2017.12 - EP); A61P 5/00 (2017.12 - EP); A61P 5/10 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/04 (2017.12 - EP); A61P 9/12 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 15/00 (2017.12 - EP); A61P 15/08 (2017.12 - EP); A61P 15/10 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/18 (2017.12 - EP); A61P 25/22 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 29/00 (2017.12 - EP); C07D 487/04 (2013.01 - EP KR US); C07D 491/107 (2013.01 - EP KR US); C07D 495/10 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
US 2010120751 A1 20100513; US 8664216 B2 20140304; AR 074317 A1 20110105; AU 2009315754 A1 20100520; AU 2009315754 A8 20110512; AU 2009315754 B2 20130815; BR PI0921110 A2 20160216; CA 2741018 A1 20100520; CL 2011001078 A1 20111111; CN 102216305 A 20111012; CN 102216305 B 20131218; CY 1113523 T1 20160622; DK 2356123 T3 20121015; EP 2356123 A1 20110817; EP 2356123 B1 20121003; ES 2391932 T3 20121203; HR P20121060 T1 20130131; IL 211939 A0 20110630; IL 211939 A 20130627; JP 2012508711 A 20120412; JP 5567027 B2 20140806; KR 101348499 B1 20140106; KR 20110074580 A 20110630; MX 2011004575 A 20110601; PE 20110537 A1 20110804; PL 2356123 T3 20130329; PT 2356123 E 20121031; RU 2011121049 A 20121220; RU 2514429 C2 20140427; SI 2356123 T1 20130131; TW 201022271 A 20100616; TW I401257 B 20130711; WO 2010054961 A1 20100520; ZA 201102522 B 20121031
DOCDB simple family (application)
US 61355409 A 20091106; AR P090104354 A 20091111; AU 2009315754 A 20091104; BR PI0921110 A 20091104; CA 2741018 A 20091104; CL 2011001078 A 20110512; CN 200980145267 A 20091104; CY 121101074 T 20121112; DK 09745058 T 20091104; EP 09745058 A 20091104; EP 2009064565 W 20091104; ES 09745058 T 20091104; HR P20121060 T 20121221; IL 21193911 A 20110324; JP 2011535965 A 20091104; KR 20117010757 A 20091104; MX 2011004575 A 20091104; PE 2011000965 A 20091104; PL 09745058 T 20091104; PT 09745058 T 20091104; RU 2011121049 A 20091104; SI 200930413 T 20091104; TW 98138124 A 20091110; ZA 201102522 A 20110405