EP 2364154 A4 20130710 - COMPOSITIONS AND METHODS FOR TREATING MATRIX METALLOPROTEINASE 9 (MMP9)-MEDIATED CONDITIONS

Title (en)

COMPOSITIONS AND METHODS FOR TREATING MATRIX METALLOPROTEINASE 9 (MMP9)-MEDIATED CONDITIONS

Title (de)

ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON MATRIX-METALLPROTEINASE-9 (MMP9)-VERMITTELTEN ERKRANKUNGEN

Title (fr)

COMPOSITIONS ET PROCÉDÉS POUR TRAITER DES AFFECTIONS VÉHICULÉES PAR LA MÉTALLOPROTÉINASE MATRICIELLE 9 (MMP9)

Publication

EP 2364154 A4 20130710 (EN)

Application

EP 09822743 A 20091022

Priority

US 2009061744 W 20091022
US 10748008 P 20081022
US 10745308 P 20081022
US 25821008 A 20081024

Abstract (en)

[origin: WO2010048425A1] Provided are methods for treating a TSLP-mediated or TSLPR-mediated disease or condition, comprising administration of an electrokinetically altered aqueous fluid comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures substantially having an average diameter of less than about 100 nanometers and stably configured in the ionic aqueous fluid in an amount sufficient for treating a TSLP-mediated or TSLPR-mediated disease or condition. The charge-stabilized oxygen-containing nanostructures are preferably stably configured in the fluid in an amount sufficient to provide for modulation of cellular membrane potential and/or conductivity. Certain aspects comprising modulation or down-regulation of TSLP expression and/or activity have utility for treating TSLP-mediated or TSLPR-mediated diseases or conditions as disclosed herein (e.g., disorders of the immune system, allergic inflammation, allergic airway inflammation, DC-mediated inflammatory Th2 responses, atopic dermatitis, atopic eczema, asthma, obstructive airways disease, chronic obstructive pulmonary disease, and food allergies, inflammatory arthritis, rheumatoid arthritis, psoriasis, IgE-mediated disorders, and rhino-conjunctivitis).

IPC 8 full level

A61K 9/00 (2006.01); A61K 31/00 (2006.01); A61K 31/573 (2006.01); A61K 33/00 (2006.01); A61K 45/06 (2006.01)

CPC (source: EP)

A61K 9/0078 (2013.01); A61K 31/00 (2013.01); A61K 45/06 (2013.01); A61P 9/00 (2017.12); A61P 9/10 (2017.12); A61P 11/00 (2017.12); A61P 11/02 (2017.12); A61P 11/06 (2017.12); A61P 17/00 (2017.12); A61P 17/02 (2017.12); A61P 17/04 (2017.12); A61P 17/06 (2017.12); A61P 19/02 (2017.12); A61P 21/02 (2017.12); A61P 25/00 (2017.12); A61P 25/06 (2017.12); A61P 25/14 (2017.12); A61P 25/16 (2017.12); A61P 25/28 (2017.12); A61P 27/14 (2017.12); A61P 29/00 (2017.12); A61P 31/00 (2017.12); A61P 31/18 (2017.12); A61P 35/00 (2017.12); A61P 37/08 (2017.12); A61P 43/00 (2017.12)

Citation (search report)

[XP] WO 2009055614 A1 20090430 - REVALESIO CORP [US], et al
[E] WO 2009134728 A2 20091105 - REVALESIO CORP [US], et al
[XD] WO 2008052143 A2 20080502 - REVALESIO CORP [US], et al
[Y] US 2003232114 A1 20031218 - DEKLEVA NIKOLA [YU]
[Y] US 2007259032 A1 20071108 - BRIGHT CORINNE [US], et al
[Y] WO 2004022098 A1 20040318 - NAGY TIBOR [HU], et al
[Y] HANS LASSMANN: "Hypoxia-like tissue injury as a component of multiple sclerosis lesions", JOURNAL OF NEUROLOGICAL SCIENCES, ELSEVIER SCIENTIFIC PUBLISHING CO, AMSTERDAM, NL, vol. 206, no. 2, 15 February 2003 (2003-02-15), pages 187 - 191, XP008137062, ISSN: 0022-510X, DOI: 10.1016/S0022-510X(02)00421-5
See references of WO 2010048455A1

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DOCDB simple family (publication)

WO 2010048425 A1 20100429; AU 2009308302 A1 20100429; AU 2009308302 B2 20160121; AU 2009308362 A1 20100429; AU 2009308362 B2 20160204; BR PI0920201 A2 20190910; BR PI0920430 A2 20190924; CA 2741336 A1 20100429; CA 2741341 A1 20100429; CN 102256607 A 20111123; CN 102256607 B 20141105; CN 102257130 A 20111123; CN 102257130 B 20160706; EP 2350263 A1 20110803; EP 2350263 A4 20130703; EP 2364154 A1 20110914; EP 2364154 A4 20130710; IL 212277 A0 20110630; IL 212309 A0 20110630; IL 212309 A 20160421; JP 2012506451 A 20120315; JP 2012506453 A 20120315; JP 2015044868 A 20150312; JP 2015044869 A 20150312; JP 5688370 B2 20150325; JP 5688371 B2 20150325; MX 2011004233 A 20110624; MX 2011004235 A 20110624; MX 337035 B 20160209; WO 2010048455 A1 20100429

DOCDB simple family (application)

US 2009061710 W 20091022; AU 2009308302 A 20091022; AU 2009308362 A 20091022; BR PI0920201 A 20091022; BR PI0920430 A 20091022; CA 2741336 A 20091022; CA 2741341 A 20091022; CN 200980151710 A 20091022; CN 200980151711 A 20091022; EP 09822721 A 20091022; EP 09822743 A 20091022; IL 21227711 A 20110412; IL 21230911 A 20110413; JP 2011533341 A 20091022; JP 2011533355 A 20091022; JP 2014246753 A 20141205; JP 2014246760 A 20141205; MX 2011004233 A 20091022; MX 2011004235 A 20091022; US 2009061744 W 20091022