EP 2365966 A4 20120509 - METHOD OF REMOVING THE TRIPHENYLMETHANE PROTECTION GROUP
Title (en)
METHOD OF REMOVING THE TRIPHENYLMETHANE PROTECTION GROUP
Title (de)
VERFAHREN ZUM ENTFERNEN DER TRIPHENYLMETHANSCHUTZGRUPPE
Title (fr)
PROCÉDÉ D'ÉLIMINATION DU GROUPE PROTECTEUR TRIPHÉNYLMÉTHANE
Publication
Application
Priority
KR 2008007364 W 20081212
Abstract (en)
[origin: WO2010067913A1] The present invention relates to a method of removing triphenylmethane protection group. The method for preparing biphenyl benzoic acid derivatives of the present invention is economically advantageous and very excellent in the aspect of improving process in that: process safety is secured by using acidic ion exchange resin in the presence of organic solvent instead of using highly corrosive acid; the reaction takes much less time than do the conventional reactions which use only anhydrous methanol and few sub-reaction does occur; and the ion-exchange resin of the present invention is excellent for mass-processing because the resin can be collected and recycled only by filtration after being used.
IPC 8 full level
C07D 257/04 (2006.01); C07D 257/02 (2006.01)
CPC (source: EP)
C07D 257/04 (2013.01); C07D 403/10 (2013.01); C07D 405/04 (2013.01); C07D 405/14 (2013.01)
Citation (search report)
- [A] WO 2006097121 A1 20060921 - ULKAR KIMYA SANAYII VE TICARET [TR], et al
- [A] EP 1988090 A1 20081105 - SHANGHAI ALLIST PHARMACEUTICAL [CN]
- See references of WO 2010067913A1
Citation (examination)
- WO 2007042161 A1 20070419 - KRKA D D NOVO MESTO [SI], et al
- KHALAFI-NEZHAD ET AL: "A catalytic method for chemoselective detritylation of 5'-tritylated nucleosides under mild and heterogeneous conditions using silica sulfuric acid as a recyclable catalyst", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 48, no. 30, 27 June 2007 (2007-06-27), pages 5219 - 5222, XP022132312, ISSN: 0040-4039, DOI: 10.1016/J.TETLET.2007.05.153
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR
DOCDB simple family (publication)
WO 2010067913 A1 20100617; EP 2365966 A1 20110921; EP 2365966 A4 20120509; JP 2012506902 A 20120322; JP 5575783 B2 20140820
DOCDB simple family (application)
KR 2008007364 W 20081212; EP 08878772 A 20081212; JP 2011534364 A 20081212