Global Patent Index - EP 2370434 B8

EP 2370434 B8 20141015 - ISOQUINOLINYL-CONTAINING ALKALOID COMPOUNDS AND COMPOSITIONS USEFUL FOR REDUCING LIPID LEVELS

Title (en)

ISOQUINOLINYL-CONTAINING ALKALOID COMPOUNDS AND COMPOSITIONS USEFUL FOR REDUCING LIPID LEVELS

Title (de)

ZUR REDUZIERUNG VON FETTSPIEGELN GEEIGNETE ISOCHINOLIN-ENTHALTENDEN ALKALOIDDERIVATE UND DEREN ZUSAMMENSETZUNGEN

Title (fr)

DÉRIVÉS ALCALOÏDES CONTENANT UN ISOQUINOLINE ET LEUR COMPOSITIONS, UTILES DANS LA RÉDUCTION DES TAUX LIPIDIQUES

Publication

EP 2370434 B8 20141015 (EN)

Application

EP 09775524 A 20091222

Priority

  • US 2009069331 W 20091222
  • US 14055108 P 20081223

Abstract (en)

[origin: WO2010075469A1] The present technology relates to compounds of Formulas (V) and (VI) and methods of making and using such compounds. Methods of use include prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome. Compounds disclosed herein also lower total cholesterol, LDL- cholesterol, and triglycerides and increase hepatic LDL receptor expression, inhibit PCSK9 expression, and activate AMP-activated potein kinase.

IPC 8 full level

C07D 455/03 (2006.01); A61K 31/4741 (2006.01); A61P 3/06 (2006.01); C07D 495/04 (2006.01)

CPC (source: EP US)

A61P 1/16 (2018.01 - EP); A61P 3/00 (2018.01 - EP); A61P 3/06 (2018.01 - EP); C07D 455/03 (2013.01 - EP US); C07D 495/04 (2013.01 - EP US)

Designated contracting state (EPC)

AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

DOCDB simple family (publication)

WO 2010075469 A1 20100701; CN 102256973 A 20111123; CN 102256973 B 20140611; EP 2370434 A1 20111005; EP 2370434 B1 20140917; EP 2370434 B8 20141015; JP 2012513413 A 20120614; JP 5551711 B2 20140716; US 2012004223 A1 20120105; US 8710071 B2 20140429

DOCDB simple family (application)

US 2009069331 W 20091222; CN 200980151491 A 20091222; EP 09775524 A 20091222; JP 2011542588 A 20091222; US 200913141310 A 20091222