EP 2370434 B8 20141015 - ISOQUINOLINYL-CONTAINING ALKALOID COMPOUNDS AND COMPOSITIONS USEFUL FOR REDUCING LIPID LEVELS
Title (en)
ISOQUINOLINYL-CONTAINING ALKALOID COMPOUNDS AND COMPOSITIONS USEFUL FOR REDUCING LIPID LEVELS
Title (de)
ZUR REDUZIERUNG VON FETTSPIEGELN GEEIGNETE ISOCHINOLIN-ENTHALTENDEN ALKALOIDDERIVATE UND DEREN ZUSAMMENSETZUNGEN
Title (fr)
DÉRIVÉS ALCALOÏDES CONTENANT UN ISOQUINOLINE ET LEUR COMPOSITIONS, UTILES DANS LA RÉDUCTION DES TAUX LIPIDIQUES
Publication
Application
Priority
- US 2009069331 W 20091222
- US 14055108 P 20081223
Abstract (en)
[origin: WO2010075469A1] The present technology relates to compounds of Formulas (V) and (VI) and methods of making and using such compounds. Methods of use include prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome. Compounds disclosed herein also lower total cholesterol, LDL- cholesterol, and triglycerides and increase hepatic LDL receptor expression, inhibit PCSK9 expression, and activate AMP-activated potein kinase.
IPC 8 full level
A61K 31/4741 (2006.01); A61P 3/06 (2006.01); C07D 455/03 (2006.01); C07D 495/04 (2006.01)
CPC (source: EP US)
A61P 1/16 (2017.12 - EP); A61P 3/00 (2017.12 - EP); A61P 3/06 (2017.12 - EP); C07D 455/03 (2013.01 - EP US); C07D 495/04 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2010075469 A1 20100701; CN 102256973 A 20111123; CN 102256973 B 20140611; EP 2370434 A1 20111005; EP 2370434 B1 20140917; EP 2370434 B8 20141015; JP 2012513413 A 20120614; JP 5551711 B2 20140716; US 2012004223 A1 20120105; US 8710071 B2 20140429
DOCDB simple family (application)
US 2009069331 W 20091222; CN 200980151491 A 20091222; EP 09775524 A 20091222; JP 2011542588 A 20091222; US 200913141310 A 20091222