EP 2373671 B1 20140910 - URACYL CYCLOPROPYL NUCLEOTIDES
Title (en)
URACYL CYCLOPROPYL NUCLEOTIDES
Title (de)
URACYLCYCLOPROPYL-NUKLEOSIDE
Title (fr)
Nucléosides d'uracyle cyclopropyle
Publication
Application
Priority
- EP 2009066562 W 20091208
- EP 08171006 A 20081208
- EP 09764845 A 20091208
Abstract (en)
[origin: WO2010066699A1] Compounds of the formula (I) including any possible stereoisomers thereof, wherein: R1 is hydrogen or halo; R4 is a monophosphate, diphosphate or triphosphate ester; or R4 is a group of formula (II) R7 is optionally substituted phenyl; naphthyl; indolyl or N-C1-C6alkyloxycarbonyl- indolyl; R8 is hydrogen, C1-C6alkyl, benzyl; R8' is hydrogen, C1-C6alkyl, benzyl; or R8 and R8' together with the carbon atom to which they are attached form C3-C7cycloalkyl; R9 is C1-C10alkyl, benzyl, or optionally substituted phenyl; or a pharmaceutically acceptable salt or solvate thereof. pharmaceutical formulations and the use of compounds I as HCV inhibitors.
IPC 8 full level
C07H 19/10 (2006.01); A61K 31/7072 (2006.01); A61P 31/14 (2006.01)
CPC (source: EP KR US)
A61K 31/7072 (2013.01 - KR); A61P 31/12 (2017.12 - EP); A61P 31/14 (2017.12 - EP); A61P 31/16 (2017.12 - EP); A61P 31/18 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07H 19/10 (2013.01 - EP KR US)
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
DOCDB simple family (publication)
WO 2010066699 A1 20100617; AP 2011005717 A0 20110630; AR 074504 A1 20110119; AU 2009326125 A1 20100617; AU 2009326125 B2 20150312; BR PI0922681 A2 20160105; CA 2745523 A1 20100617; CA 2745523 C 20170704; CL 2011001364 A1 20110923; CN 102256991 A 20111123; CN 102256991 B 20150812; EA 020244 B1 20140930; EA 201170780 A1 20111230; EP 2373671 A1 20111012; EP 2373671 B1 20140910; ES 2525007 T3 20141217; IL 212897 A0 20110731; IL 212897 A 20131231; JP 2012510980 A 20120517; JP 5683480 B2 20150311; KR 20110104000 A 20110921; MX 2011006023 A 20110628; PA 8852101 A1 20100727; SG 171973 A1 20110728; TW 201036989 A 20101016; US 2011230436 A1 20110922; US 8399429 B2 20130319; UY 32308 A 20100630; ZA 201104231 B 20121128
DOCDB simple family (application)
EP 2009066562 W 20091208; AP 2011005717 A 20091208; AR P090104736 A 20091207; AU 2009326125 A 20091208; BR PI0922681 A 20091208; CA 2745523 A 20091208; CL 2011001364 A 20110607; CN 200980150162 A 20091208; EA 201170780 A 20091208; EP 09764845 A 20091208; ES 09764845 T 20091208; IL 21289711 A 20110516; JP 2011539051 A 20091208; KR 20117015453 A 20091208; MX 2011006023 A 20091208; PA 8852101 A 20091203; SG 2011040979 A 20091208; TW 98141651 A 20091207; US 200913130602 A 20091208; UY 32308 A 20091208; ZA 201104231 A 20110607